Credit: The American Journal of Pathology
In response to a high oxygen insult, the lungs of wild-type mice (left-hand side) show alveolar simplification and enlargement, septal wall thickening (blue arrow), and leukocyte infiltration (black arrows), all features seen in human disease. Deficiency of granulocyte colony-stimulating factor (G-CSF) in mice (G-CSF-/-) markedly protects the lungs from these traits (right-hand side).