A new study published online this week in the American Journal of Human Genetics from Penn researchers uncovers the mechanisms of the genetic mutations, or variants, associated with the TMEM106B gene.
People who have a healthier diet throughout their adult lives are more likely to be stronger and fitter in older age than those who don’t, according to a new study led by the University of Southampton.
University of Iowa researchers report that a roundworm can learn to put on alert a defense system important for protecting cells from damage. The finding could lead to a new approach for treating neurodegenerative diseases in humans caused by damaged cells.
Scientists now believe that the Fountain of Youth flows from our genes, or at least from the genes of people who live healthy lives to age 100 or later. To discover what’s special about the genes of centenarians—and apply that knowledge to extend the healthy lives of the rest of us—the NIH has awarded researchers at Albert Einstein College of Medicine and The Scripps Research Institute (TSRI) a five-year, $9 million grant.
Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals. In a Nature Communications study published today, researchers showed that worms with excess levels of certain proteins lived longer and healthier than normal worms. In addition, mice with excess levels of these proteins demonstrated a delay in blood vessel dysfunction associated with aging. The study has major implications for our understanding of aging and age-associated disorders.
A proposal to humanize several mouse genes for research into Alzheimer’s disease has spurred the National Institute on Aging to award $11.35 million to the University of California, Irvine.
Scientists drilling down to the molecular roots of Alzheimer’s disease have encountered a good news/bad news scenario. The bad news is that in the early stages of the disease, high-risk TREM2 variants can hobble the immune system’s ability to protect the brain from amyloid beta. The good news, according to researchers at Washington University School of Medicine in St. Louis, is that later in the disease, the absence of TREM2 protein seems to protect the brain from damage.
Indiana University has been awarded a one-year, $7.6 million grant from the National Institute on Aging (NIA) to establish a network of sites to study early-onset Alzheimer’s disease.
A researcher at the University of Kentucky is exploring whether low doses of Rapamycin, a drug commonly used as an immunosuppressant for organ transplant recipients, can restore brain function before the disease changes in the brain affect a person's memory.
Gulf War veterans with low-level exposure to chemical weapons show lasting adverse effects on brain structure and memory function, reports a study in the October Journal of Occupational and Environmental Medicine.
Women who develop high blood pressure in their 40s may be more likely to develop dementia years later, according to a study published in the October 4, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
While the social and economic cost of Alzheimer’s is well documented, a new study shows that frontotemporal degeneration (FTD)—the most common dementia for people under age 60—inflicts a significantly higher economic burden on both patients and their caregivers. It found that the average annual costs associated with FTD to total $119,654, nearly two times the reported annual cost of Alzheimer’s.
According to a new study, frontotemporal degeneration (FTD), the most common dementia for people under age 60, inflicts a much more severe economic burden on patients and their caregivers than Alzheimer’s disease, as well as other forms of dementia that typically show their first symptoms later in life.
Cross-Sector Collaboration Aimed at Speeding the Development of Potential Therapies That May Protect Brain Cells
A long-term study of nearly 3,000 older adults found that those who could not identify at least 4 out of 5 common odors were more than twice as likely as those with a normal sense of smell to develop dementia within five years. About 14% could name just 3, 5% percent could identify only 2, and 2% could name just 1. One percent of the study subjects were not able to identify a single scent.
A new zinc sensor has been developed by researchers, which will allow for a deeper understanding of the dynamic roles that metal ions play in regulating health and disease in the living body.
Many people with schizophrenia have trouble with learning and memory. A new study has found intriguing links between sleep, cognition and a compound called kynurenine. These links could illuminate the mechanism that causes cognitive problems among those with the disease, and could point the way to new treatments to reduce some of the disease’s symptoms.
Contrary to previous research, caffeine may not relieve movement symptoms for people with Parkinson’s disease, according to a study published in the September 27, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
National Institutes of Health supports education in Alzheimer’s disease at Rensselaer Polytechnic Institute
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