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The study, published online Nov. 12 in TheLancetOncology,augments previous work by Vanderbilt University Medical Center (VUMC) researchers who first reported in 2016 rare but fatal cardiac side effects from the most widely prescribed class of immunotherapies. The researchers used VigiBase, a global database of drug complications maintained by the World Health Organization, to track adverse cardiovascular reactions in the latest study.

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A Penn Medicine study, published online today in the Journal of the American College of Cardiology, showed that even after controlling for risk factors like income, education, smoking, and exercise, among others, black patients remained at significantly higher risk for SCD than white patients.

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ISPOR Europe 2018 session explored the evolving European Union policy landscape with panelists discussing if Europe is on the right path to improve outcomes research of medical devices.

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ISPOR Europe 2018 session explored health technology assessment value-based pricing versus WHO fair pricing to assess which approach best delivers universal health coverage.

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For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors. The study from The University of Texas MD Anderson Cancer Center, which includes two patients, suggests fecal microbiota transplantation is worth investigating in clinical trials as a therapy for this common side effect of immunotherapy.

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An experimental drug may be effective against a deadly form of pancreatic cancer when used in combination with other immune-boosting therapies, according to a cover study publishing online Nov. 12 in Cancer Cell.

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A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors. The paradoxical findings, published today in Nature Medicine, give cancer doctors important new information when choosing drugs and other treatments for cancer patients.

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A nurse’s ability to provide optimal patient care is influenced by a variety of factors – not just how many patients he or she is caring for or how sick they might be, a new study suggests.

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The mechanisms that trigger the elimination of T cells that pose autoimmune dangers work very mechanically via physical forces. Nascent T cells must loosen their grip on human antigens within a reasonable time, in order to advance and defend the body. But if the nascent T cells, thymocytes, grip the human antigens too tightly, the immune cells must die. Here's how the grip of death works.

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Hepatitis C drugs cure more than 90 percent of patients, but can cost more than $50,000 per patient. Findings from a new study could lead to big cost savings. In 50 percent of patients, the standard 12-week treatment regimen could be shortened to as little as six weeks without compromising efficacy.

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A session, “Healthcare X.0: Digital Technologies and Creation of Value,” at ISPOR Europe 2018 explored how digital technologies are creating the next generation healthcare system in Europe and beyond.

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ISPOR Europe 2018 session, “Will Machines Soon Make Health Economists Obsolete?” explored the impact of machine learning on health economics.

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ISPOR Europe 2018 opened this morning with its first plenary, “Joint Assessment of Relative Effectiveness: ‘Trick or Treat’ for Decision Makers in the EU Member States,” a session on the impact of the European Commission’s Draft Regulation on health technology assessment.

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New research released today from the University of South Australia and University of Exeter in the UK has found the strongest evidence yet that obesity causes depression, even in the absence of other health problems.

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A research team from Massachusetts Eye and Ear describes a newly discovered mechanism in a report published in the Journal of Allergy and Clinical Immunology (JACI). The findings shed new light on our immune systems — and also pave the way for drug delivery techniques to be developed that harness this natural transportation process from one group of cells to another.

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Researchers at University of California San Diego School of Medicine, Scripps Institution of Oceanography, and international collaborators have evidence that Kawasaki Disease (KD) does not have a single cause. By studying weather patterns and geographical distributions of patients in San Diego, the research team determined that this inflammatory disease likely has multiple environmental triggers influenced by a combination of temperature, precipitation and wind patterns.

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The 2018 American Heart Association Scientific Sessions

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Can your smart phone determine if you’re having the most serious – and deadly – form of heart attack? A new research study says it can – and may be a valuable tool to save lives.

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A new study presented at the American Heart Association Scientific Session conference has found that patients with atrial fibrillation (AF) also show signs of asymptomatic brain injury.

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Heart complications in patients diagnosed with bacterial pneumonia are more serious than in patients diagnosed with viral pneumonia, according to new research from the Intermountain Heart Institute at Intermountain Medical Center in Salt Lake City.