Heart attacks are not as connected to family history and genetics as may have been previously believed, according to a new study by researchers at the Intermountain Medical Center Heart Institute in Salt Lake City.
A research team led by scientists from the National University of Singapore (NUS) has identified several potent inhibitors that selectively target FTO, the common fat mass and obesity-associated gene.
A JAMA study found that sequencing the DNA of children with mystery genetic disorders produced a definitive diagnosis in 40 percent of UCLA’s most complex cases--a quantum leap from the field’s 5-percent success rate 20 years ago.
A team led by researchers at The Rockefeller University and the Icahn School of Medicine at Mount Sinai has explained the function of key immune protein and solved an international medical mystery, according to a letter published this week in the journal Nature.
Rochester, Minn. – The American Academy of Neurology (AAN) and the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) offer a new guideline on how to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy. The guideline is published in the October 14, 2014, print issue of Neurology®, the medical journal of the AAN.
Scientists reveal crucial steps and surprising structures in the genesis of the enzyme that divides the DNA double helix during cell replication
SIRT6—a protein that inhibits the growth of liver and colon cancers—can promote the development of skin cancers by turning on an enzyme that increases inflammation, proliferation and survival of sun-damaged skin cells. This suggests that SIRT6 could provide a useful target for cancer prevention.
Research in zebrafish has helped identify the cause of an unknown genetic disorder affecting a boy and two of his uncles, scientists report in the journal GENETICS. The researchers tracked down a mutation carried only by the affected males and their mothers, within a gene called RPL10 . When the equivalent gene was suppressed in zebrafish, the animals developed smaller heads, which is one of the major symptoms of the human disease.
By studying a protein called beta-1,3-glucan recognition protein in the blood of a caterpillar, researchers have found a genetic mechanism that may help trigger an insect's immune system into killing pathogens in the insect's blood.
Slow-healing or non-healing bone fractures in otherwise healthy people may be caused by gene variants that are common in the population, according to Penn State College of Medicine researchers.
A new guideline from the American Academy of Neurology (AAN) and the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) recommends guidance on how doctors should evaluate the full picture—from symptoms, family history and ethnicity to a physical exam and certain lab test results—in order to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy. The guideline is published in the October 14, 2014, print issue of Neurology®, the medical journal of the American Academy of Neurology.
A new guideline recommends guidance on how doctors should evaluate the full picture in order to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy.
The application of a new, precise way to turn genes on and off within cells is likely to lead to a better understanding of diseases and possibly to new therapies, according to UC San Francisco scientists.
Like a marching band falling out of step, muscle cells fail to perform in unison in patients with Duchenne muscular dystrophy. Researchers reveal how this breakdown leads to the proliferation of stiff fibrotic tissue within muscles.
UI researchers have found a gene in a soil amoeba that can overcompensate for the specific mutations of a similar gene. In humans, those genetic mutations can often lead to tumor growth. Researchers are now looking for a separate human gene that could overcompensate for mutations in the same way.
The genes children inherit determine everything from their height to their hair color. But sometimes, a child’s genetic code also contains hidden abnormalities that can cause an array of health issues, such as developmental delays or physical or mental illness. Linda Randolph, MD, head of the Division of Medical Genetics at Children’s Hospital Los Angeles (CHLA) explains how a medical geneticist works “like a detective” to diagnose genetic syndromes—and put children on the path to better health.
Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first evidence that DNA structure does indeed have such effects—in this case finding a link between chromosome structure and the expression and repression of key genes.
On the 25th anniversary of discovering the cystic fibrosis gene, more than two-dozen CF innovators and clinicians, including five on the Case Western Reserve campus, took this special occasion to reflect on the discovery and the status of research and treatment during videotaped interviews.
Researchers at Children’s Hospital Los Angeles (CHLA) have described for the first time a specific perceptual learning deficit in mice with a mutation of the same gene as found in children with Fragile X Syndrome (FXS).
A new discovery suggests that the number of human genomic loci that might be coding for tRNAs is nearly double what is currently known.
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