Cedars-Sinai scientists have revealed the origins of a common ovarian cancer by modeling fallopian tube tissues, allowing them to characterize how a genetic mutation puts women at high risk for this cancer. The created tissues, known as organoids, hold potential for predicting which individuals will develop ovarian cancer years or even decades in advance, allowing for early detection and prevention strategies.
A potential new route to the diagnosis and treatment of ARDS comes from studying how neutrophils – the white blood cells responsible for detecting and eliminating harmful particles in the body – differentiate what materials to uptake by the material’s surface structure, and favor uptake of particles that exhibit “protein clumping.”
Researchers demonstrated that the SWI/SNF complex facilitates access to enhancers that oncogenes can bind to and drive downstream gene expression in cancer. Degrading a subunit of this complex blocks the oncogenes. The finding reveals a novel approach to treating prostate cancers fueled by different genetic drivers, which altogether represent upwards of 90% of all prostate cancers.
Penn Medicine has been awarded a prestigious seven-year, $14 million grant from the National Institutes of Health (NIH) to promote organ transplantation for patients with end-stage renal disease who are currently on the waitlist for a kidney transplant. The team will launch a clinical trial harnessing synthetic chimeric antigen receptor (CAR) T cells – a form of which was developed at Penn Medicine and became the first personalized cellular therapy for cancer – for use in patients for whom a compatible kidney cannot be found due to pre-existing antibodies against potential donors.
A new study by researchers at Washington University School of Medicine in St. Louis and St. Jude Children’s Research Hospital helps explain why mRNA vaccines have been so successful at preventing severe disease.
UC San Diego engineers developed a powerful new tool that directly measures the movement and speed of electrical signals inside heart cells, using tiny “pop-up” sensors that poke into cells without damaging them. It could be used to gain more detailed insights into heart disorders and diseases.
Study identifies racial and ethnic disparities in hospital mortality for COVID and non-COVID patients alike, highlights urgent need to address systemic inequities in health care and improve care for those who are impacted the hardest by the virus, directly and indirectly.
Scientists at the La Jolla Institute for Immunology (LJI) have uncovered how loss of TET enzymes can lead to B cell lymphoma. Their research, published in Nature Immunology, could potentially open opportunities for designing drug treatment strategies to target malignant cells in many cancers.
Making initiation of buprenorphine easy and timely was associated with a 25 percent increase in the likelihood of its use of treatment in Penn Medicine emergency departments
Argonne is part of a new DOE program called Horizon-broadening Isotope Production Pipeline Opportunities (HIPPO), which aims to develop the future isotope production workforce.
The Robert David Lion Gardiner Foundation (RDLGF) has awarded SUNY distinguished professor of history Michael Leroy Oberg, the SUNY Geneseo Center for Local and Municipal History, and a consortium of six other colleges and universities a three-year grant of more than $300K for The Gardiner Foundation Semiquincentennial Student Fellowship Program.
Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health (NIH) totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.
A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.
Pulmonary embolisms are dangerous, lung-clogging blot clots. In a pilot study, scientists at the Icahn School of Medicine at Mount Sinai showed for the first time that artificial intelligence (AI) algorithms can detect signs of these clots in electrocardiograms (EKGs), a finding which may one day help doctors with screening.
Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer’s disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer’s prevention trials, this one will enroll people before the disease has taken hold – up to 25 years before the expected onset of dementia.
Using angiographic images and computer modeling and analysis, researchers in Japan have evaluated hemodynamic factors that may help identify sites where aneurysms are likelier to form.
To solve the mysteries of how learning and memory occur, Johns Hopkins Medicine scientists have created a system to track millions of connections among brain cells in mice — all at the same time — when the animals’ whiskers are tweaked, an indicator for learning.
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– The Penn Artificial Intelligence and Technology Collaboratory for Healthy Aging (PennAITech) seeks to explore the use of artificial intelligence and other technologies to improve in-home care for older adults and individuals with Alzheimer’s disease. The Collaboratory will leverage extensive expertise in artificial intelligence, consumer informatics and aging, access to patient cohorts and resources of Penn’s School of Nursing, the Perelman School of Medicine, and other departments across the University of Pennsylvania.
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A team of scientists led by the University of Michigan Health Rogel Cancer Center has found that a class of U.S. Food and Drug Administration-approved drugs can effectively stop a highly aggressive type of uterine cancer in its tracks, paving a quick path toward new treatment strategies for a deadly cancer with limited therapeutic options.
Research from the lab of Kimberly Parker at the McKelvey School of Engineering looks at the interactions of different herbicides and what they mean for herbicide drift.
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