Feature Channels: Liver Disease

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Researchers at UT Southwestern Medical Center have discovered how healthy bacteria can escape the intestine, travel to lymph nodes and cancerous tumors elsewhere in the body, and boost the effectiveness of certain immunotherapy drugs. The findings, published in Science Immunology, shed light on why antibiotics can weaken the effect of immunotherapies and could lead to new cancer treatments.

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A United States Food and Drug Administration mandate to limit the dosage of acetaminophen in pills that combine acetaminophen and opioid medications is significantly associated with subsequent reductions in serious liver injury.

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A new study by researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system shows that people who have been infected with COVID-19 are at an increased risk of developing a range of gastrointestinal conditions within the first month to a year after illness.

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Now, in a surprising new discovery, Harvard Medical School researchers have found that a class of regulatory T cells (Tregs) made in the gut play a role in repairing injured muscles and mending damaged livers. In an even more unexpected twist, the researchers found that gut microbes fuel the production of Tregs, which act as immune healers that go on patrol around the body and respond to distress signals from distant sites of injury.

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Is unsedated transnasal esophagoscopy safe for patients with cirrhosis? How good is ultrasound at assessing fibrosis in children with fatty liver disease? These are just a few of the questions addressed in presentations this past fall by faculty from the Division of Gastroenterology, Hepatology and Nutrition at Children’s Hospital Los Angeles.

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When parts of the liver are removed, the body can replace the missing tissue.

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The Center for Liver and Hepatobiliary Diseases at Mercy in conjunction with the University of Maryland Medical Center (UMMC) assists patients through the liver transplant process.

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Researchers from the Organoid group (former Clevers group, Hubrecht Institute) together with researchers from the Princess Máxima Center for pediatric oncology established novel human organoid models of fatty liver disease.

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As a child in Beirut, Ahmad Anouti, M.D., endured dozens of medical procedures, hundreds of medications, and numerous setbacks before a liver transplant at age 16 saved his life. Today, Dr. Anouti is a postdoctoral research fellow at UT Southwestern Medical Center specializing in hepatology.

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Below are some of the latest articles that have been added to the Chemistry news channel on Newswise.

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Living donation and significantly lower wait times helped the program to perform 35 liver transplants in 2022. Children’s Hospital Los Angeles leads the nation in liver transplants performed at a pediatric center, according to new data released from the Organ Procurement & Transplantation Network (OPTN), which oversees organ transplants in the U.

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Nutrition researchers studied 80 people with nonalcoholic fatty liver disease and found that those who followed an alternate-day fasting diet and exercised were able to improve their health. In Cell Metabolism, the researchers report that over a period of three months people in the intervention saw increased insulin sensitivity and decreased liver fat, weight and ALT, or alanine transaminase enzymes, which are markers for liver disease.

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The University of Chicago Medicine liver transplant teams performed their 2,000th liver transplant in 2022, a milestone figure for the South Side academic medical center.

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Cleveland Clinic performed 1,050 transplants in 2022, including heart, kidney, liver, intestine and lung transplants, as well as living donor transplantation for kidney and liver. That is up 1% from the number of transplants performed at Cleveland Clinic in 2021.

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University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.

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A detailed snapshot of proteins by PNNL scientists marks a big step toward a diagnostic blood test for a deadly form of liver disease – alcohol-associated hepatitis.

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Penn State College of Medicine researchers confirmed exercise can lead to meaningful reductions in liver fat for patients with nonalcoholic fatty liver disease.

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Tuomas Sandholm’s work since 2010 to improve the fairness and effectiveness of organ donations using PSC supercomputers has won the 2023 AAAI Award for Artificial Intelligence for the Benefit of Humanity.

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Below are some of the latest articles that have been added to the Surgery and the Transplantation channels on Newswise, a free source for journalists.