Laura D'Ignazio, Ricardo S. Jacomini, Bareera Qamar, Kynon J.M. Benjamin, Ria Arora, Tomoyo Sawada, Taylor A. Evans, Kenneth E. Diffenderfer, Aimee R. Pankonin, William T. Hendriks, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger, D. Cristopher Bragg, Apua C.M. Paquola, Jennifer A. Erwin
M. Guy Roukens, Lydia S. Schulla, E. Diana Alupoaie, Leanne De Silva, Debby Gawlitta, Sabine Middendorp, Paul J. Coffer
Bikul Das, Seema Bhuyan, Bidisha Pal, Lekhika Pathak, Partha Jyoti Saikia, Shirsajit Mitra, Sukanya Gayan, Reza Bayat Mokhtari, Hong Li, Chilakamarti V Ramana, Debabrat Baishya
Pien Goldsteen, Angelica Sabogal Guaqueta, Sophie Bos, Loes Kistemaker, Luke Van der Koog, Manon Eggens, Andrew J Halayko, Amalia Dolga, Reinoud Gosens
BACKGROUNDBone marrow (BM) suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to irradiation. Despite concerted efforts, there is no definitive treatment method available. Recent
BACKGROUNDThe generation of induced pluripotent stem cells (iPSC) has been a game-changer in translational and regenerative medicine; however, their large-scale applicability is still hampered by the scarcity of accessible, safe, and reproducib
Ningxia Liang, Qian Wang, He Zhang, Zhaomin Li, Taotao Chen, FaXiang Xu, Zhixin Guo, Guokai Chen, Huang-Tian Yang, Dongjin Wang, Guangji Wang, Jiaxian Wang
Michael J Xiao, Chia-Hua Wu, Graham Meek, Brian Kelly, Lyndsay E.A Young, Sara Martire, Dara Buendia Castillo, Purbita Saha, Altair L Dube, Matthew Gentry, Laura A Banaszynski, Ramon C Sun, Chintan Kikani
Nidheesh Dadheech, Abhay Srivast, Rashmi G. Shah, Girish M. Shah, Sarita Gupta
Maorui Zhang, Yujin Gao, Qing Li, Huayue Cao, Jianghua Yang, Xiaoxiao Cai, Jingang Xiao
Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao
… In this study, we hypothesized that several paracrine cytokines exist in stem cell culture media that may facilitate the immunomodulation of macrophages. The IL4 treatment of stem cells could lead to a greater production of those compounds which …
Schizophrenia (SCZ) is a devastating and complicated mental disorder accompanied by variable positive and negative symptoms and cognitive deficits. Although many genetic risk factors have been identified, SCZ is also considered as a neurodevelo
Theoretically, mesenchymal stem cells (MSCs) are very promising as adjuvant therapy to alleviate coronavirus disease 2019 (COVID-19)-associated acute lung injury and cytokine storm. Several published studies, which used MSCs to alleviate COVID-
In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized ApoA1 knockout mice.
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or transplantation and multidrug resistance development during pharmacotherapy leads to high death rates for HCC patients.
Amirreza Niazi Tabar, Hossein Azizi, Mehdi Mehdinezhad Roshan, Hiva Alipour
Quentin Felty, Jayanta K Das, Alok Deoraj, Deodutta Roy
Lijun Zeng, Ranli Gu, Yuzi Shao, Yuan Zhu, Zhengwei Xie, Hao Liu, Yongsheng Zhou
Yang-Yang Lei, Yi Wang, Xin-Rui Chen, Mei Guo, Chang-Lin Yu, Jian-Hui Qiao, Bo Cai, Shan Jiang, Hui-Sheng Ai, Kaixun Hu
Yu Lun, Yang Zuming
… Recent clinical successes for gene therapies involving autologous HSC transplantation (HSCT) demonstrate the potential of genetic engineering in this stem cell type for curing disease. With recent advances in CRISPR gene-editing …
Delivery of Stem Cell Secretome for Therapeutic Applications F Li, J Zhang, K Yi, H Wang, H Wei, HF Chan, Y Tao… - ACS Applied Bio Materials, 2022 … delivery of stem cell secretome deserve more attention. In this review, we first discuss approaches for the production and characterization of stem cell secretome and their optimization strategies. Moreover, the up-to-date studies to improve the … [HTML] Cancer Stem Cell Markers for Urinary Carcinoma P Xia, DH Liu, ZJ Xu, F Ren - Stem Cells International, 2022 … Cancer stem cell (CSC) refers to cancer cells with stem cell properties, that is, they have the ability of “self-renewal” and “differentiation.” … In this review, cancer stem cell surface markers and functional markers in urinary system were summarized …
There is no clear genetic etiology or convergent pathophysiology for autism spectrum disorders (ASD). Using induced pluripotent stem cell (iPSC)-derived brain organoids and single-cell transcriptomics, we modeled alterations in the formation of the forebrain between sons with ASD and their unaffected fathers in ten families. Relative to fathers, probands with macrocephaly presented an increase in dorsal cortical plate excitatory neurons (EN-DCP) to the detriment of preplate lineages, whereas normocephalic ASD probands presented an opposite decrease in EN-DCP-related gene expression. Both cohorts converged in a dysregulation of outer radial glia genes related to translation.
Tracing the impact of a single protein, Piezo1, Penn researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently
A research group led by Kazunobu Sawamoto, a professor at Nagoya City University and National Institute for Physiological Sciences, and Chihiro Kurematsu, a student at Nagoya City University School of Medicine, has elucidated the mechanism that controls synaptic pruning of new neurons in the adult brain. These findings are expected to be useful in the study of neurological diseases with abnormalities in microglia and synapses, such as autism spectrum disorders (ASDs).
Iowa State University scientists are examining a genetic pathway triggered when cells undergo inflammation due to injury or infection that also plays an important role in the development of blood stem cells. The research could lead to the ability to treat blood diseases by regenerating a patient’s blood cells.
J. Joseph Melenhorst, Ph.D., has been appointed director of the new Cell Therapy and Immuno-Engineering Program, and Vice Chair of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.
… protein C receptor (EPCRhigh) were enriched within the stem cell fraction at the expense of more proliferative EPCRLow HSCs. These … stem cell function. We herein attempted to elucidate the mechanisms by which HSCs convert the effects of …
NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell tra … usefulness of NK cellderived IFNg inhibition to favor engraftment in allogeneic hematopoietic stem cell transplantation (HSCT) …
… In addition, MSCs derived from different donors and tissues lead to individual heterogeneity, which complicates the progress of consistent and standardized stem cell production. Therefore, it is necessary to screen qualified MSCs to avoid uncertain effects. …
To evaluate the safety and early outcomes of autologous bone marrow mononuclear cell (BMMNC) infusion for liver cirrhosis due to biliary atresia (BA) after Kasai operation.
The short-term safety and efficacy of stromal vascular fraction (SVF) in treating knee osteoarthritis (KOA) have been extensively studied but the mid-term and long-term prognoses remain unknown.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right