Feature Channels: Respiratory Diseases and Disorders

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Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more aggressive and difficult to treat. Researchers at Moffitt Cancer Center are hoping to change that. In a new study published in Cancer Research, the team discovered a new treatment approach that may help this group of patients.

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A new study from Washington University School of Medicine in St. Louis supports evidence that children with mild asthma can effectively manage the condition by using their two inhalers — one a steroid and the other a bronchodilator — when symptoms occur. This is in contrast to the traditional method of using the steroid daily, regardless of symptoms, and the bronchodilator when symptoms occur. The as-needed use of both inhalers is just as effective for mild asthma as the traditional protocol, according to the investigators.

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Castleman Disease patients who do not respond to the only drug currently approved by the FDA may have another option that targets a specific pathway called PI3K/Akt/mTOR

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Long-term exposure to air pollution was linked to increases in emphysema between 2000 and 2018, according to a new study funded by the National Institute of Environmental Health Sciences (NIEHS) and the National Heart, Lung, and Blood Institute (NHLBI), both part of the National Institutes of Health.

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Air pollution—especially ozone air pollution which is increasing with climate change—accelerates the progression of emphysema of the lung, according to a new study led by the University of Washington, Columbia University and the University at Buffalo.

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Long-term exposure to outdoor air pollutants, especially the pollutant ozone, accelerates the development of emphysema and age-related decline in lung function, even among people who have never smoked, according to a study published in the Journal of the American Medical Association.

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$3.4 Million Study to Understand Why Older Adults Have Worse Asthma Outcomes

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Irvine, Calif., Aug. 12, 2019 – Hookah waterpipe use has grown in popularity in recent years – 1 in 5 college students in the U.S. and Europe have tried it – but the practice could be more dangerous than other forms of smoking, according to a first-of-its-kind study by researchers at the University of California, Irvine, published recently in Aerosol Science and Technology.

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Boehringer Ingelheim and MD Anderson have announced a new multi-year partnership to conduct collaborative research, combining the drug-development capabilities of MD Anderson with the pipeline of novel medicines from Boehringer Ingelheim.

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Conhecido por seu prognóstico precário, o adenocarcinoma de pulmão é o tipo de câncer de pulmão mais comum, responsável por aproximadamente 4 de 10 diagnósticos, de acordo com o National Institute of Cancer. Os pesquisadores do campus da Flórida da Mayo Clinic agora podem distinguir entre duas vias onde esse câncer fatal pode se desenvolver.

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Das Lungenadenokarzinom ist bekannt für seine schlechte Prognose und laut National Cancer Institute mit etwa 4 von 10 Diagnosen die häufigste Form von Lungenkrebs. Forscher auf dem Mayo Clinic Campus in Florida können nun zwischen zwei Signalwegen unterscheiden, auf denen sich dieser tödliche Krebs entwickeln kann.

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美国国家癌症研究所的研究表明，肺腺癌是最常见的肺癌类型，且公认预后较差，每10例肺癌诊断中约有4例为肺腺癌。Mayo Clinic佛罗里达院所的研究人员现在可以区分这种致命癌症的两种可能发生途径。他们表示其发现可以帮助未来的患者。研究结果发表在Cancer Cell（《癌细胞》）期刊上。

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Connu pour son pronostic défavorable, l'adénocarcinome pulmonaire est le type le plus commun de cancer du poumon, responsable d'environ 4 diagnostics sur 10, selon l'Institut national du cancer. Des chercheurs du campus de Floride de la Mayo Clinic peuvent désormais distinguer deux voies de développement de ce cancer mortel.

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Certain traits may define a type of obstructive sleep apnea that can be effectively treated with an oral appliance, according to new research published online in the Annals of the American Thoracic Society.

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Despite improved knowledge of the molecular alterations in SCC, little is understood about how the alterations contribute to the development of the cancer and how potential vulnerabilities could be exploited to treat the disease. Researchers in Moffitt Cancer Center’s Lung Cancer Center of Excellence took a closer look at SCC tumors to determine if their characteristics had an impact on patient outcomes. The findings were published today in Nature Communications.

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UW Medicine’s lung-transplant team, the only such providers in the Pacific Northwest, performed their 1,000th transplant on July 7, 2019. Ten other U.S. programs have reached such a milestone. Lindsey Decker, 33, of Tri-Cities, Washington, received two donor lungs and was patient No. 1,000.

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– Old lungs are not as capable as young lungs of fighting off an infection of the bacteria that causes tuberculosis (TB), placing seniors at a greater risk of developing TB. The microbe that causes this infectious disease, Mycobacterium tuberculosis (Mtb), currently kills more people in the world than any other pathogen. Texas Biomed researchers published an article in the Journal of Infectious Diseases in July 2019. The study details an experiment that took place in vitro (in the lab) and in vivo (in animals) that showed fluid in the lining of the lungs plays a big role in the elderly’s susceptibility to infection with the bacterium Mtb.