UT Southwestern immunologists have uncovered a key pathogenic event prompted by obesity that can trigger severe forms of nonalcoholic fatty liver disease and potential liver failure.
Using a specialized MRI sensor, MIT researchers have shown that they can detect light deep within tissues such as the brain.
Protein detection based on antigen–antibody reaction is vital in early diagnosis of a wide range of diseases. How to effectively detect proteins, however, has frequently bedeviled researchers.
For the first time, researchers at UC San Diego have shown that changes in gene expression happen almost entirely during the transcription stage while the cells are growing. The researchers have provided a simple quantitative formula linking regulatory control to mRNA and protein levels.
After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome — a rare genetic, neurocognitive disorder.
In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.
Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels.
In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a study published in the December 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person’s own body to replace diseased cells.
Irvine, Calif., Dec. 21, 2022 — A research team led by the University of California, Irvine has linked the mutation that causes Huntington’s disease to developmental deficits in the brain’s oligodendrocyte cells that are caused by changes in metabolism. They found that high doses of thiamine and biotin can restore normal processes.
For decades, scientists have been stumped by the signals plants send themselves to initiate photosynthesis, the process of turning sunlight into sugars. UC Riverside researchers have now decoded those previously opaque signals.
How did the complex organisms on Earth arise? This is one of the big open questions in biology. A collaboration between the working groups of Christa Schleper at the University of Vienna and Martin Pilhofer at ETH Zurich has come a step closer to the answer. The researchers succeeded in cultivating a special archaeon and characterizing it more precisely using microscopic methods.
Researchers from Children’s Hospital of Philadelphia (CHOP) and New Jersey Institute of Technology (NJIT) developed new software that integrates a variety of information from a single cell, allowing researchers to see how one change in a cell can lead to several others and providing important clues for pinpointing the exact causes of genetic-based diseases.
Modern humans evolutionarily split from our chimpanzee ancestors nearly 7 million years ago, yet we are continuing to evolve.
Neuroscience graduate students at Children’s Hospital Los Angeles have developed an automated method that could save time and work for laboratories around the country by streamlining the process of identifying and mapping brain cells. Scientists want to understand how brain cells develop over time because the way these cells, called neurons, develop, influences how they function, or how they malfunction in neurodevelopmental disorders.
Female bees and wasps use modified ovipositors, formerly used in egg laying, to sting their attackers, including people.
Jessica Thaxton’s group at the UNC School of Medicine found that T cells exposed to the environment of solid cancers undergo a natural response to stress that shuts off their function, limiting T cell ability to kill tumors.
Researchers from Paul Scherrer Institute PSI and ETH Zurich have discovered how proteins in the cell can form tiny liquid droplets that act as a smart molecular glue.
Researchers from Boston Children’s Hospital and Harvard, using Argonne’s Advanced Photon Source, have characterized the structure of integrins, a type of cell surface receptor involved in the immune response.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts. Current advances include a cell cycle checkpoint inhibitor with potential therapeutic effects in an ovarian cancer subtype, a telementoring program for French-speaking oncology providers in Africa, insights into the relationship between obesity and immunotherapy side effects, updates to the world’s largest cancer drug discovery knowledgebase, improvements to treatment response by blocking the EGFR pathway, and a novel noninvasive diagnostic test for immunotherapy-related kidney injury.
The Donnan electric potential arises from an imbalance of charges at the interface of a charged membrane and a liquid, and for more than a century it has stubbornly eluded direct measurement. Many researchers have even written off such a measurement as impossible. But that era, at last, has ended. With a tool that’s conventionally used to probe the chemical composition of materials, scientists at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) recently led the first direct measurement of the Donnan potential.
BioVU, Vanderbilt University Medical Center’s biobank, has reached another milestone — deep-freeze storage of more than 300,000 biological samples.
A recent study by researchers from the NUS Yong Loo Lin School of Medicine and the Memory, Ageing and Cognition Centre under the National University Health System revealed that low levels of ergothioneine in blood plasma may predict an increased risk of cognitive impairment and dementia, suggesting possible therapeutic or early screening measures for cognitive impairment and dementia in the elderly.
Pancreatic cancer remains one of the deadliest malignancies worldwide.
Octopuses have captured the attention of scientists and the public with their remarkable intelligence, including the use of tools, engaging in creative play and problem-solving, and even escaping from aquariums.
Researchers at UC San Diego provide new insights into the pathology of limbic predominate age-related TDP-43 encephalopathy, which mimics Alzheimer’s, making it very difficult to identify in living patients.
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science led 70 participants from 14 nations in a discussion on the ways in which a gene drive project registry could both contribute to and detract from the fair development, testing and use of gene-drive modified organisms.
Se diagnosticaron aproximadamente 620 000 nuevos casos de linfoma en todo el mundo, según el informe del World Cancer Research Fund International de 2020. Las tasas de supervivencia han mejorado a medida que se desarrollan avances en el tratamiento, como la terapia de células T con receptores quiméricos de antígenos.
ROCHESTER, Minn.—Cerca de 620.000 novos casos de linfoma foram diagnosticados em todo o mundo, de acordo com o relatório do Fundo Mundial para Pesquisa em Câncer de 2020. As taxas de sobrevivência melhoraram à medida que se desenvolvem os avanços no tratamento, como a terapia de células T com receptor de antígeno quimérico.
根据世界癌症研究基金会2020年的报告，全球在该年度新诊断出约620,000例淋巴瘤。随着在治疗手段上取得进步，例如嵌合抗原受体-T细胞疗法的推出，患者的存活率有所提升。
تم تشخيص ما يقرب من 620,000 ألف حالة جديدة باللمفومة في جميع أنحاء العالم، وفقًا لتقرير الصندوق العالمي لبحوث السرطان لعام 2020. وقد تحسنت معدلات النجاة مع تطور في العلاج، مثل: العلاج بالخلايا التائية ذات مستقبلات المستضدات الخيمرية.
Researchers at UBC’s Life Sciences Institute have identified a compound that shows early promise at halting infections from a range of coronaviruses, including all variants of SARS-CoV-2 and the common cold.
Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.
A new report on the ethics of crossing species boundaries by inserting human cells into nonhuman animals – research surrounded by debate – makes recommendations clarifying the ethical issues and calling for improved oversight of this work.
Using models, researchers at UC San Diego School of Medicine, with colleagues elsewhere, describe using RNA-targeting CRISPR/Cas13d technology to develop a new therapeutic strategy that specifically eliminates toxic RNA that causes Huntington’s Disease.
A good night's sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply?
A new study led by Yves Brun shows how some bacteria living in a biofilm sacrifice themselves to ensure the survival of the community.
A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
Researchers from the University of Pennsylvania’s Abramson Cancer Center presented preliminary results of an ongoing Phase I clinical trial demonstrating successful re-treatment with CAR T cell therapy for patients whose cancers relapsed after previous CAR T therapy at the 2022 American Society of Hematology (ASH) Annual Meeting (Abstract 2016).
Scientists at Johns Hopkins Medicine say they have developed a computer model — dubbed quantitative fate mapping — that looks back in the developmental timeline to trace the origin of cells in a fully grown organism.
Northwestern University researchers have discovered a previously unknown mechanism that drives aging.
This special edition features presentations by MD Anderson researchers at the 2022 American Society of Hematology (ASH) Annual Meeting on innovative targeted therapies, new combination approaches and novel targets to improve outcomes for patients with leukemias, Hodgkin lymphoma, non-Hodgkin lymphoma, myeloma and other hematologic cancers.
Scientists showed that nucleolar protein nucleophosmin ( NPM1), the defection of which can cause the development of leukemia and other types of cancer, deals with its regulatory protein only by phosphorylation of nucleophosmin (including “phosphate marker” in its composition).
The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer.
A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.
The American Neuromuscular Foundation (ANF), is excited to announce the 2022 Development Grant Recipient, Stefan Nicolau, MD, for his research project “CRISPR/Cas9 correction of a common Duchenne muscular dystrophy (DMD) deletion.” Dr. Nicolau is a research fellow at the Abigail Wexner Research Institute at Nationwide Children’s Hospital in Columbus, OH.
Scientists at Johns Hopkins Medicine say that a key to cellular movement is to regulate the electrical charge on the interior side of the cell membrane, potentially paving the way for understanding cancer, immune cell and other types of cell motion.
Many pathogenic viruses, including herpesviruses, SARS -Cov-2, cytomegalovirus, papillomavirus, virus Nipah and others, use the similar mechanism to join the target cells, which consists in their attachment to heparan sulfate proteoglycan of the cell membrane.
Researchers from the Liston lab, at the Babraham Institute, have recently published a preventative therapeutic for diabetes in mice.
Autoimmune diseases are thought to be the result of mistaken identity. Immune cells on patrol, armed and ready to defend the body against invading pathogens, mistake normal human cells for infected cells and turn their weapons on their own healthy tissues.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
