A cell therapy approach to prevent muscle atrophy and paralysis in an aggressive mouse model of ALS
PreprintsBarney Bryson, Alexandra Kourgiantaki, Dai Jiang, Andreas Demosthenous, Linda Greensmith
Feature Channels: Stem Cells
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Released: 25-Aug-2022 12:00 PM EDT
Released: 25-Aug-2022 12:00 PM EDT
p16High senescence restricts totipotent potential during somatic cell reprogramming
PreprintsBogdan B Grigorash, Dominic van Essen, Laurent Grosse, Alexander Emelyanov, Benoit Kanzler, Clement Molina, Elsa Lopez, Oleg N Demidov, Carmen Garrido, Simona Saccani, Dmitry Bulavin
Released: 25-Aug-2022 12:00 PM EDT
Identification of DOT1L Inhibitor in a Screen for Factors that Promote Dopaminergic Neuron Survival
PreprintsJun Cui, Joseph S Carey, Renee A Reijo Pera
Released: 24-Aug-2022 12:00 PM EDT
High Percentage of Cancer Stem Cells in Metastatic Locations: Upregulation of circBIRC6 in Highly Metastatic Breast Cancer Subline
PreprintsMohammad Kamalabadi Farahani, Roqaye Karimi, Amir Atashi
Released: 24-Aug-2022 12:00 PM EDT
XIST Regulates Breast Cancer Stem Cells by Activating Proinflammatory IL-6 Signaling
PreprintsYuxi Ma, Yongyou Zhu, Li Shang, Yan Qiu, Na Shen, Qingxuan Song, Jun Li, Max S. Wicha, Ming Luo
Released: 24-Aug-2022 12:00 PM EDT
JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis
PreprintsLisa Nguyen, Michelle Westerhoff, Leonie Thewes, Wasco Wruck, Andreas S Reichert, Carsten Berndt, James Adjaye
Released: 24-Aug-2022 12:00 PM EDT
Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer
PreprintsBetul Cicek, Serhat Hayme, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Ahmet Hacimuftuoglu
Released: 24-Aug-2022 12:00 PM EDT
Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice
PreprintsJing Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li, Chunfang Wang, Kah-Leong Lim, Chengwu Zhang, Wulin Yang, Li Lu
Released: 23-Aug-2022 12:00 PM EDT
A mathematical model integrates diverging PXY and MP interactions in cambium development
PreprintsK. S. Bagdassarian, J. P. Etchells, N. S. Savage
Released: 23-Aug-2022 12:00 PM EDT
Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Differentiation of Aortic Valve Cells Through STAT5
PreprintsRolando A Cuevas, Luis Hortells, Claire Chu, Ryan Wong, Alex Crane, Camille Boufford, Caylin Regan, William Moorhead, Michael Bashline, Aneesha Parwal, Angeline Parise, Aditi Gurkar, Dennis Bruemmer, John Sembrat,
Released: 23-Aug-2022 12:00 PM EDT
Effects of miR-629-5p on odontoblast differentiation and target gene TEAD4 expression of dental pulp stem cells
PreprintsJianpeng Han, Xin Zhao, Rongrong Jiang, Chengfeng Jiang, Lei Li, Zhiliang Xu, Yihua Song, Xingmei Feng
Released: 23-Aug-2022 12:00 PM EDT
High intensity interval training protects the heart against acute myocardial infarction through SDF-1a, CXCR4 receptors and c-kit levels
PreprintsMohsen Bapiran, Hamid Rajabi, Farinaz Nasirinezhad, Fatemeh Ramezani, Reza Ghanimati, Maral Ramez
Released: 23-Aug-2022 12:00 PM EDT
Mesenchymal stem cells polarize macrophages to an anti-inflammatory phenotype to ameliorate diabetic nephropathy
PreprintsLinxi Zhang, Songyan Yu, Yu Cheng, Zhengyuan Gong, Jing Xue, Bing Li, Yaqi Yin, Junyan Zou, Rui Wei, Tianpei Hong, Yiming Mu
Released: 23-Aug-2022 12:00 PM EDT
Metabolic enhancement of mammalian developmental pausing
PreprintsVera A van der Weijden, Maximilian Stoetzel, Beatrix Fauler, Dhanur P Iyer, Mohammed Shahraz, David Meierhofer, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioglu
Released: 23-Aug-2022 12:00 PM EDT
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
PreprintsKeli Lima, Diego Antonio Pereira-Martins, Livia Bassani Lins de Miranda, Juan Luiz Coelho-Silva, Giovana Da Silva Leandro, Isabel Weinhauser, Rita De Cassia Cavaglieri, Aline Medeiros de Leal, Wellington Fernandes da Silva, Ana Paula Alencar De Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger,
Released: 23-Aug-2022 12:00 PM EDT
The effect of haploidentical hematopoietic stem cell transplantation on comutations based on next-generation sequencing in adult acute myeloid leukemia patients with the FLT3-ITD mutation
PreprintsXiao-Jun Huang, Fei-Fei Tang, Xiao-Su Zhao, Guo-Rui Ruan, Qian Jiang, Hao Jiang, Lan-Ping Xu, Xiao-Hui Zhang
Released: 23-Aug-2022 12:00 PM EDT
The preceding hyponatremia is a useful hallmark for the diagnosis of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation
PreprintsTakahide Ara, Shota Yoshida, Kohei Okada, Yuto Mori, Shihori Tsukamoto, Naoki Miyashita, Kohei Kasahara, Ko Ebata, Junko Iwasaki, Shojiro Takahashi, Akio Shigematsu, Koichiro Minauchi, Naoki Kobayashi, Masahiro Ogasawra,
Released: 23-Aug-2022 12:00 PM EDT
Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function
PreprintsMiranda K Culley, Monica Mehta, Jingsi Zhao, Dror Perk, Yi Yin Tai, Ying Tang, Sruti Shiva, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y Chan
Released: 23-Aug-2022 12:00 PM EDT
Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells
PreprintsMahekta Rajeshkumar Gujar, Yang Gao, Xiang Teng, Qiannan Deng, Ye Sing Tan, Yusuke Toyama, Hongyan Wang
Released: 22-Aug-2022 3:15 PM EDT
Untapped potential of stem cells could aid repair of spinal cord damage
Francis Crick InstituteScientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice.
Released: 22-Aug-2022 12:00 PM EDT
Human Embryonic Stem Cell-derived Cerebral Organoids for Treatment of Mild Traumatic Brain Injury in a Mouse Model
PreprintsJong-Tae Kim, Sung Min Cho, Dong Hyuk Youn, Tae Yeon Kim, Sung Woo Han, Chan Hum Park, Younghyurk Lee, Eun Pyo Hong, Harry Jung, Jae Jun Lee, Jong Kook Rhim, Jeong Jin Park, Jun Hyong Ahn, Heung Cheol Kim,
Released: 22-Aug-2022 12:00 PM EDT
Transplantation of human umbilical cord mesenchymal stem cells induces angiogenesis and promotes repair of uterine scars in rats
PreprintsXiuyin Shen, Xin Luo, Shuzhen Wu, Yingchun Wan, Huiting Ma, Shaoxin Ye, Zhuoling Zhang, Min Lu, Hai Tang, Xiaoyan Gou, Xiaoling Guo, ZhengPing Liu
Released: 22-Aug-2022 12:00 PM EDT
Cortical interneuron development is affected in leukodystrophy 4H
PreprintsStephanie Dooves, Liza M.L. Kok, Dwayne B. Holmes, Nicole Breeuwsma, Marjolein Breur, Marianna Bugiani, Nicole Wolf, Vivi M Heine
Released: 22-Aug-2022 12:00 PM EDT
Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overview
PreprintsAshwani Choudhary, Ritu Nayak, David Peles, Liron Mizrahi, Shani Stern
Released: 22-Aug-2022 12:00 PM EDT
A nationwide survey of late effects in survivors of juvenile myelomonocytic leukemia in Japan
PreprintsShuichi Ozono, Kazuo Sakashita, Nao Yoshida, Harumi Kakuda, Kenichiro Watanabe, Miho Maeda, Yasushi Ishida, Atsushi Manabe, Takashi Taga, Hideki Muramatsu
Released: 22-Aug-2022 12:00 PM EDT
Differentiation of human induced pluripotent stem cells into cortical neural stem cells
PreprintsAlexandra Neaverson, Malin H.L. Andersson, Osama A. Arshad, Luke Foulser, Mary Goodwin-Trotman, Adam Hunter, Ben Newman, Minal Patel, Charlotte Roth, Tristan Thwaites, Helena Kilpinen, Matthew E. Hurles, Andrew Day, Sebastian S. Gerety
Released: 22-Aug-2022 12:00 PM EDT
Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome system
PreprintsShinta Tominaga, Toshiyasu Ojima, Motoki Miyazawa, Hiromitsu Iwamoto, Junya Kitadani, Shimpei Maruoka, Keiji Hayata, Hiroki Yamaue
17-Aug-2022 4:35 PM EDT
The Locked Library: Disease Causes Cells to Reorder Their DNA Incorrectly
Perelman School of Medicine at the University of PennsylvaniaWith super-resolution imaging, Penn Medicine researchers discovered that cells change the physical structure of their genome when they’re affected by disease
Released: 20-Aug-2022 12:00 PM EDT
Molecular evolution and inheritance pattern of Sox gene family among Bovidae
PreprintsMabel O Akinyemi, Muyiwa S Adegbaju, Anastasia Grytsay, Osamede H Osaiyuwu, Jessica Finucan, Ibukun M Ogunade, Sunday O Peters, Bolaji N Thomas, Olanrewaju B Morenikeji
Released: 19-Aug-2022 12:00 PM EDT
C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway under LPS-induced inflammation
PreprintsMuhammad Irfan, Seung Chung
Released: 19-Aug-2022 12:00 PM EDT
Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging
PreprintsXiaoai Zhao, Xin Yan, Kévin Contrepois, Francesco Vallania, Mathew Ellenberger, Chloe M. Kashiwagi, Stephanie D. Gagnon, Cynthia J. Siebrand, Matias Cabruja, Gavin M. Traber, Andrew McKay, Daniel Hornburg, Purvesh Khatri, Michael P.
Released: 19-Aug-2022 12:00 PM EDT
NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naive pluripotent stem cells
PreprintsKatsiaryna Maskalenka, Gokberk Alagoz, Felix Krueger, Joshua Wright, Maria Rostovskaya, Asif Nakhuda, Adam Bendall, Christel Krueger, Simon Walker, Aylwyn Scally, Peter Rugg-Gunn
Released: 19-Aug-2022 12:00 PM EDT
Hematopoietic Stem Cell Gene Therapy Alleviates Disease Phenotypes in a Murine Model of Danon Disease
PreprintsChao Chen, Sherin Hashem, Jay Sharma, Ana Maria Manso, Paul Bushway, Jason Duran, Emily Gault, Yusu Gu, Jose Cano Nigenda, Angel Soto-Hermida, Kirk Peterson, Paul Saftig, Stephanie Cherqui, Sylvia Evans,
Released: 18-Aug-2022 3:55 PM EDT
Immune cell model paves way for new treatments targeting common infection amongst immunocompromised children
Murdoch Childrens Research InstituteResearchers have successfully engineered human immune cells to model an infection common among immunocompromised people in a breakthrough discovery, paving the way for new drug testing and treatments.
Released: 18-Aug-2022 12:00 PM EDT
Gilteritinib-induced severe immune-related enteritis: a possible case report
PreprintsPan Luo, Huiyin Qiu, Yushan Yang, Jiaqi Wu, Xianmin Song, Guorong Fan, Gaolin Liu, Junwei Gao
Released: 18-Aug-2022 12:00 PM EDT
hucMSC-derived exosomes ameliorate pressure ulcers by inhibiting HMGB1.
PreprintsFei Yan, Meihua Gong, Fu-Rong Li, Li Yu
Released: 18-Aug-2022 12:00 PM EDT
Mesenchymal stromal cell encapsulation in uniform chitosan beads using microchannel emulsification
PreprintsDongjin S Shin, Francesco K Touani, Damon G.K Aboud, Anne Kietzig, Sophie Lerouge, Corinne A Hoesli
Released: 18-Aug-2022 12:00 PM EDT
Loss of LRP1 in adult neural stem cells impairs migration to ischemic lesions
PreprintsKristi Dietert, Swetha Mahesula, Sheetal Hegde, John Verschelde, Pamela Reed, Shane Sprague, Erzsebet Kokovay, Naomi L Sayre
14-Aug-2022 2:05 PM EDT
Why We Fit A Mini Brain with a Mini Cap
Johns Hopkins UniversityIt could be the world’s tiniest EEG electrode cap, created to measure activity in a brain model the size of a pen dot. Its designers expect the device to lead to better understanding of neural disorders and how potentially dangerous chemicals affect the brain. This engineering feat, led by Johns Hopkins University researchers and detailed today in Science Advances, expands what researchers can accomplish with organoids, including mini brains—the lab-grown balls of human cells that mimic some of a brain’s structure and functionality.
Released: 17-Aug-2022 12:00 PM EDT
Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy
PreprintsHoma Majd, Sadaf Amin, Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo Arroyo, Karen Lankford, Sina Farahvashi, Angeline K Chemel, Mesomachukwu Okoye, Megan D Scantlen, Jason Tchieu, Elizabeth L Calder, Valerie LeRouzic, Abolfazl Arab,
Released: 17-Aug-2022 12:00 PM EDT
Growth of Mesenchymal Stem Cells at the Surface of Silicone, Mineral and Plant-Based Oils
PreprintsLihui Peng, Julien E Gautrot
Released: 16-Aug-2022 4:05 PM EDT
Cell Mapping Close to the Bone
King Abdullah University of Science & Technology (KAUST)Tissues contain many different cell types, and it remains challenging to understand how they interact and contribute to tissue function.
Released: 16-Aug-2022 2:05 PM EDT
Many paths are open to neurons born early
University of BonnWhen it comes to royalty, things are clear: The monarch's first child inherits the crown. Siblings born later must make do with a less glamorous profession.
Released: 16-Aug-2022 12:00 PM EDT
The oncogenic roles of John Cunningham virus T antigen in digestive epithelial cells with tissue specificity
PreprintsHuachuan Zheng, Hang Xue, Ying E, Zhengguo Cui
Released: 16-Aug-2022 12:00 PM EDT
Mass spectrometry imaging reveals early metabolic priming of cell lineage in differentiating human induced pluripotent stem cells
PreprintsArina A. Nikitina, Alexandria Van Grouw, Tanya Roysam, Danning Huang, Facundo M. Fernandez, Melissa L. Kemp
Released: 16-Aug-2022 12:00 PM EDT
Implanted hair-follicle-associated pluripotent (HAP) stem cells differentiating to keratinocytes, macrophages and endothelial cells accelerated cutaneous wound closure and suppressed scar formation in a mouse model
PreprintsKoya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Ayami Hasegawa, Nanao Takaoka, Ryoichi Aki, Robert M. Hoffman, Yasuyuki Amoh
Released: 16-Aug-2022 12:00 PM EDT
Enablers and barriers to referral and delivery of multidisciplinary prehabilitation in the Autologous Stem Cell Transplant population: A theory-based interview study
PreprintsJessica Crowe, Lara Edbrooke, Amit Khot, Linda Denehy, Jill J Francis
Released: 16-Aug-2022 12:00 PM EDT
Fludarabine/TBI 8 Gy versus fludarabine/treosulfan conditioning in patients with AML in first complete remission: A Study from the Acute Leukemia Working Party of the EBMT
PreprintsGesine Bug, Myriam Labopin, Riitta Niittyvuopio, Matthias Stelljes, Christian Reinhardt, Inken Hilgendorf, Nicolaus Kroeger, Ain Kaare, Wolfgang Bethge, Kerstin Schaefer-Eckart, Mareike Verbeek, Stephan Mielke, Kristina Carlson, Ali
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