Cal State LA hosted some of the region’s leading bioscience research institutions at the Los Angeles Venture Association’s (LAVA) First Look L.A. 2017
A new microscope merges different microscopy methods to increase resolution and contrast in thick biological samples. A key component of the method is two-photon microscopy, used to generate a small point of light deep inside the sample. By moving this light throughout the sample and collecting information on how it is being distorted, Shroff and his team are able to adjust the shape of the mirror to cancel out the distortions, thus creating a clear image of the whole sample.
Electrostatic forces known as phosphate steering help guide the actions of an enzyme called FEN1 that is critical in DNA replication and repair, finds a new study led by Berkeley Lab researchers. The findings help explain how FEN1 distinguishes which strands of DNA to target, revealing key details about a vital process in healthy cells as well as providing new directions for cancer treatment research.
New research explains navigation in the fundamental cargo transport process that occurs in every cell in the human body and may point to therapeutic targets for a host of diseases like cancer.
Harvard Medical School study generates near-atomic resolution images of key steps in CRISPR-Cas3 function, revealing layers of error detection that prevent unintended genomic damage. Structural understanding informs efforts to improve CRISPR systems for gene editing and reduce off-target effects.
Using nanotechnology, image processing tools and statistical analysis, Technion researchers have developed a system that enables faster diagnostics, earlier and more effective treatment of infectious bacteria, and improved patient recovery times.
Adding the equivalent of a miniature tornado to the interface between electrospray ionization (ESI) and a mass spectrometer (MS) has allowed researchers to improve the sensitivity and detection capability of the widely-used ESI-MS analytical technique.
A team led by UC San Diego researchers has identified, for the first time, the myriad structural changes that activate and drive CRISPR-Cas9, the innovative gene-splicing technology that’s transforming the field of genetic engineering.
UC San Diego Extension will host its annual Industrial Biotechnology Workshops on Aug. 14 through 18. Participants can attend the whole program or attend the workshops on microbial fermentation or metabolic engineering separately.
Scientists at the Pacific Northwest National Laboratory and Oregon Health & Science University are part of a nationwide effort to learn more about the role of proteins in cancer biology and to use that information to benefit cancer patients.
Scientists at the University of Wisconsin-Madison Morgridge Institute for Research have, for the first time, imaged molecular structures vital to how a major class of viruses replicates within infected cells.
Just as people endlessly calculate how to upsize or downsize, bacteria continually adjust their volume (their stuff) to fit inside their membrane (their space). But what limits their expansion? The answer will surprise you.
Most organisms share the biosynthetic pathways for making crucial nutrients because it is is dangerous to tinker with them. But now a collaborative team of scientists has caught plants in the process of altering where and how cells make an essential amino acid.
Engineers at Washington University in St. Louis and Princeton University developed a new way to dive into the cell's tiniest and most important components. What they found inside membraneless organelles surprised them, and could lead to better understanding of fatal diseases including cancer, Huntington's and ALS.
A new UW microscope could provide real-time results during cancer-removal surgeries, potentially eliminating the 20 to 40 percent of women who have to undergo multiple lumpectomy surgeries because cancerous breast tissue is missed the first time around.
Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at Rutgers University-New Brunswick in collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.
In their recent study, published in the Journal of Virology, the University of Wisconsin–Madison researchers examined 35 years worth of invited speaker rosters from four prominent virology meetings, including the American Society for Virology, which is hosting its annual meeting in Madison, Wisconsin starting June 24, 2017. They found that men were overwhelmingly represented.
With SLAC’s X-ray laser and synchrotron, scientists measured exactly how much energy goes into keeping a crucial chemical bond from triggering a cell's death spiral.
Scientists have developed a new low-temperature catalyst for producing high-purity hydrogen gas while simultaneously using up carbon monoxide (CO). The discovery could improve the performance of fuel cells that run on hydrogen fuel but can be poisoned by CO.
Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.
A review published today in AACC’s Clinical Chemistry journal has identified 10 genes that show promise in predicting how patients will respond to opioid pain medications. Using these genetic markers, healthcare providers could potentially tailor opioid therapy better to curb the skyrocketing rate of deaths from these drugs.
Researchers at the University of Michigan Life Sciences Institute have identified a new type of rapid-response defense mechanism that helps protect cells from environmental stress while giving slower, well-known protection systems time to act.
A new study from the Monell Center and collaborating institutions advances understanding of how stem cells on the tongue grow into the different types of mature taste cells that detect either sweet, salty, sour, bitter, or umami. The findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine-tune a person’s taste perception to encourage healthier eating.
Johnson & Johnson Launches Campaign for Champions of Science
Vanderbilt engineers have designed a “granular jamming cap” filled with coffee grounds that can improve the accuracy of the sophisticated “GPS” system that surgeons use for nose and throat surgery.
Researchers from the Stowers Institute for Medical Research in collaboration with Fred Hutchinson Cancer Research Center researchers have identified an unprecedented genetic survival strategy that would be right at home in an Agatha Christie murder mystery novel.
A newly discovered metabolic process linking different bacteria in a community could enhance bioenergy production.
David Geffen School of Medicine at UCLA awards 2017 Swtizer Prize to Dr. Huda Zoghbi, a neurologist who revealed the molecular basis of neurological disorders.
At present, the only FDA approved method of treating glaucoma is to lower eye pressure; this slows the progression of glaucomatous optic nerve damage but does not completely halt it, and certainly does not regenerate damaged nerve tissue.
A team of scientists has developed a method to create structures whose building blocks are a millionth of a meter in size by encoding DNA with assembly instructions.
Hand over hand. That's how new, near-atomic resolution, 3-D snapshots show that a key biological machine unfolds a ribbon of protein through its central channel.
AACC, a global scientific and medical professional organization dedicated to better health through laboratory medicine, is pleased to announce that the impact factor of its journal, Clinical Chemistry, has risen to 8.008 in the 2016 Thomson Reuters Journal Citation Reports. This impact factor places Clinical Chemistry in the top 2.6% of 12,062 ranked academic journals and speaks to the significant influence of the science it publishes on laboratory medicine and patient care.
Being able to quiet active neutrophils with a dual-beam laser could lead to new treatments for lung injury.
An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ’s developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells. The scientists report online in Nature on June 14 that their bioengineered human liver tissues still need additional rounds of molecular fine tuning before they can be tested in clinical trials.
A Southern Research team led by President and CEO Art Tipton will travel to next week’s BIO International conference for focused meetings that center on a promising pipeline of early-stage drug candidates for diseases such as Alzheimer’s, Parkinson’s, diabetes and cancer.
By tagging a cell’s proteins with fluorescent beacons, Cornell University researchers have found out how E. coli bacteria defend themselves against antibiotics and other poisons. Probably not good news for the bacteria.
UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme called Set2 found in virtually all organisms other than bacteria. The basic science finding may have implications for understanding cancer development and how to halt it.
The new research may have important implications for fundamental biology and diseases like ALS.
Imagine wearing a device that continuously analyzes your sweat or blood for different types of biomarkers, such as proteins that show you may have breast cancer or lung cancer. Rutgers engineers have invented biosensor technology – known as a lab on a chip – that could be used in hand-held or wearable devices to monitor your health and exposure to dangerous bacteria, viruses and pollutants.
"DNA is a bully." That's how researcher Jeffrey Skolnick sums up the dominant power of DNA motion among the forces acting upon transcription factors as they move through DNA's winding thickets to their target sites. He and Edmond Chow have programmed a very large, unique simulation that tests and corroborates the hypothesis.
Microbes play important roles in regulating Earth’s biogeochemical cycles and in Nature Biotechnology, U.S. Department of Energy Joint Genome Institute scientists report the release of 1,003 phylogenetically diverse bacterial and archaeal reference genomes—the single largest release to date.
Every day billions of cells die in our body and need to be replaced by newly dividing cells. Cell division is a beautifully orchestrated process that involves multiple critical steps. At the very end, “cellular abscission” splits the membrane and thereby gives birth to two daughter cells. Abscission is executed by a protein machinery named ESCRT-III. ESCRT-III consists of many subunits that form spiral-shaped filaments to constrict the membrane tube connecting the daughter cells until it splits. Insights into the function of ESCRT-III are also interesting for many other biological processes – as this machinery also pinches off viruses from the host cell membrane, and seals holes in cellular and nuclear membranes.
Fungi are rich sources of natural molecules for drug discovery, but numerous challenges have pushed pharmaceutical companies away from tapping into this bounty. Now scientists at Northwestern University, the University of Wisconsin-Madison and the biotech company Intact Genomics have developed technology that uses genomics and data analytics to efficiently screen for molecules produced by molds to find new drug leads -- maybe even the next penicillin. From three diverse fungal species, the research team discovered 17 new natural products.
Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper to be published June 13 in Regeneration. The research has implications for human and animal space travelers and for regenerative and bioengineering science.
Researchers at the Weizmann Institute of Science have found that in utero exposure to stress, then experiencing stressors after birth, can lead to overeating disorders in females. However, the scientists were able to prevent the onset of the disorders through dietary intervention.
Maya Schuldiner of the Weizmann Institute of Science in Israel has won the prestigious EMBO Gold Medal for 2017. At a ceremony on December 4 at the 2017 ASCB/EMBO meeting in Philadelphia, Schuldiner will receive the medal and present her research at the EMBO Gold Metal Lecture.
American Association of Anatomists (AAA) is proud to announce the newest Editor-in-Chief of our leading developmental biology journal, Developmental Dynamics. Paul Trainor, Ph.D., Investigator at Stowers Institute for Medical Research was approved by the Board of Directors in April 2017, and will take over as Editor-in-Chief on January 1, 2018.
A University of Arkansas biologist is studying heat-stress response in yeast to help determine the role of protein acetylation in cells
One of the newest entities with the Penn Institute for Biomedical Informatics, the Health Language Processing Lab combines social media content with other sources of health information in a unique way aimed at understanding how people use language to communicate health needs.
When many individual neurons collect data, how do they reach a unanimous decision? New research from the Santa Fe Institute's collective computation group suggests a two-phase process.
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