Using a physician anesthesiologist-led Anesthesia Care Team model increases patient access to care, compared to nurse-administered sedation for gastrointestinal (GI) endoscopy procedures, according to research being presented at the American Society of Anesthesiologists’ ADVANCE 2022, the Anesthesiology Business Event.
Credentialed press representatives are invited to attend The Society of Thoracic Surgeons VIRTUAL 58th Annual Meeting.
Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy—also pioneered at Penn—for solid cancer tumors and offers a promising new strategy in the fight against cancer. Preliminary data from the Phase 1 multi-center clinical trial, which uses a novel, gene-based cancer therapy with CAR-engineered macrophages to target recurrent or metastatic HER2-positive solid tumors, was presented during the recent Society for Immunotherapy of Cancer (SITC) annual meeting.
Complimentary press passes are now available for the Experimental Biology (EB) 2022 meeting, to be held April 2–5 in Philadelphia. EB is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
Researchers from UCLA Jonsson Comprehensive Cancer Center and UCLA Health will participate in dozens of presentations at the annual meeting of the American Society of Hematology (ASH), held virtually and in person in Atlanta Dec. 11-14. A few of these are highlighted here.
A drug combination can safely prevent transplanted stem cells (graft) from attacking the recipient’s (host) body, allowing them to develop into healthy new blood and immune cells, a new study shows.
Blood clots or thromboembolic complications in patients with COVID-19 are associated with increased levels of various proteins that cause blood to clot, compared with people with blood clots unrelated to COVID-19, according to a small study by Yale Cancer Center researchers. These findings may offer insights into novel therapeutic strategies to treat patients with COVID-19 related blood clots. The findings were reported today at the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition in Atlanta, Georgia.
The final results from a national phase 2 study including researchers from Yale Cancer Center show the drug tipifarnib increased survival rates for patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). The findings are being presented today at the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition in Atlanta, Georgia.
Combination therapies including venetoclax and another therapy have displayed promising results against subtypes of acute myeloid leukemia (AML) that are particularly difficult to treat, including relapsed or refractory AML with a specific mutation, high-risk AML and treated secondary AML. Researchers from The University of Texas MD Anderson Cancer Center presented numerous studies involving venetoclax combination therapy for AML at the 2021 American Society of Hematology (ASH) Annual Meeting.
Young patients with chronic lymphocytic leukemia (CLL) can enjoy long remissions on the drug ibrutinib, but must stay on it indefinitely to keep the cancer in remission. A new study by Dana-Farber Cancer Institute researchers suggests that a 2.5-year regimen involving ibrutinib and chemoimmunotherapy can provide deep, and lasting remissions of the disease.
Researchers from Rutgers Cancer Institute of New Jersey, the state’s only NCI-designated Comprehensive Cancer Center, examined the effects of SIRT1, an enzyme located primarily in the cell nucleus that contributes to cellular regulation on the transformation of T-cells.
For patients with the blood cancer multiple myeloma, vaccination against COVID-19 provides some protection against coronavirus infection but to a far lower degree than the general population of cancer survivors, a new study by Dana-Farber Cancer Institute investigators shows.
Roswell Park Comprehensive Cancer Center hematology experts in leukemia, lymphoma and other specialties will present new research at the 63rd annual meeting of the American Society of Hematology (ASH), which begins today in Atlanta, Georgia. The many research projects to be highlighted include breakthrough research on CAR T cell therapy, immunotherapy, leukemia, lymphoma and the management of genetic mutations in aggressive and rare blood cancers.
Mount Sinai physician-scientists have found that a novel therapy for the bone marrow cancer myelofibrosis is safe and well-tolerated and is associated with modest improvements in patients in a Phase 1b clinical trial. They shared their findings during an oral presentation at the American Society of Hematology annual meeting in December.
The first results from the largest screening study yet conducted in the U.S. of individuals at above-average risk for the blood cancer multiple myeloma have revealed higher rates of a myeloma precursor condition in older adults who are Black or who have a close family member with a current or past blood cancer.
Chimeric antigen receptor T-cell therapy or CAR T is a breakthrough treatment for patients with certain types of blood cancers. The cellular therapy uses a patient’s own immune cells that are reengineered to better seek out and destroy cancer cells. The single infusion treatment is approved for patients who have relapsed after two or more types of therapy but results from the ZUMA-7 clinical trial show lymphoma patients can benefit from receiving the CAR T product axicabtagene ciloleucel (Yescarta) sooner.
Three clinical studies led by researchers at The University of Texas MD Anderson Cancer Center demonstrated enhanced responses for patients with high-risk lymphoma treated with axicabtagene ciloleucel (axi-cel) chimeric antigen receptor (CAR) T cell therapy. These results were reported at the 2021 American Society of Hematology (ASH) Annual Meeting.
Findings from a new study led by Yale Cancer Center show the small molecule inhibitor drug, PF05175157, originally developed to treat diabetes by Pfizer, may help in the treatment of breast cancer. The findings were reported today at the 2021 San Antonio Breast Cancer Symposium in San Antonio, Texas.
Researchers from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a part of the Georgetown Lombardi Comprehensive Cancer Center, will present updates on treatment advances in multiple myeloma, lymphoma, leukemia, and bone marrow transplantation at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually and live at the Georgia World Congress Center in Atlanta from December 11-14, 2021.
Flooding is the most expensive natural disaster in the United States, according to the National Oceanic and Atmospheric Administration (NOAA), costing the country more than $1 trillion in inflation-adjusted dollars since 1980. Rising sea level and more intense storms could be devastating for the more than 40 percent of Americans who live in coastal areas.
New research led by Yale Cancer Center reveals young women with breast cancer and a family history of the disease, but no high penetrance germline mutations, have an increased number of rare germline variants in cancer-relevant genes.
Physicians and researchers presented the latest scientific developments into pulmonary fibrosis and interstitial lung disease at its biennial PFF Summit in November. Registration is still open at PFFSummit.org to view all sessions on-demand through Feb. 20, 2022.
For most children with renal masses, the standard of care has long been to remove the entire affected kidney—which is the protocol for Wilms tumor, the most common kidney cancer in children. But is it possible for surgeons to perform partial nephrectomies in some patients with renal masses—safely removing the mass, but leaving the child’s kidney in place?Pediatric urologist Andy Chang, MD, Vice Chair of Operations for the Department of Surgery at Children’s Hospital Los Angeles, recently led a study to investigate this question, and he will present the results in December at The Societies for Pediatric Urology Fall Congress in Miami.
During pandemic-induced isolation, researchers from the University of Minnesota surveyed older adults with vision loss, with hearing loss, or without either condition, asking the participants about their worries, well-being, and social isolation at six-week intervals. All three groups scored lower on a patient health questionnaire after the pandemic began; however, people with vision or hearing loss faced unique problems in lockdown. Disruptions to mobility systems affected people with low vision, and masks made conversations especially difficult for adults with hearing loss.
Difficulty in understanding speech, especially in background noise, is a common concern for older adults. Using a word identification task in quiet and noisy conditions, researchers examined the impact of mild dementia on speech perception. They tested individuals with and without mild dementia and found that word identification scores of those without dementia were significantly better in all conditions, meaning people with mild dementia symptoms recalled fewer words in both quiet and noisy situations.
Techniques in neuroimaging and neurocomputational modeling are leading to a much better understanding of brain function during speech and how stuttering arises. Inside the brain, one circuit initiates the desired speech in the basal ganglia, while another circuit coordinates the muscles needed to generate the speech. Stuttering stems from the initiation of speech, so only the first of the two circuits is impaired. This theory matches behavioral observations of stuttering.
Researchers have developed microbubbles to acoustically detect blood oxygen levels, since the microbubble shells are altered by structural hemoglobin changes in response to oxygen. The gas filling of the microbubbles causes them to oscillate and vibrate when ultrasound is applied, scattering energy and generating an acoustic response that can be detected by a clinical ultrasound scanner. Preliminary results show a strong correlation between oxygen concentration and the acoustic bubble response.
Scientists from Cedars-Sinai are gearing up to send stem cells into space to test whether it is possible to produce large batches in zero gravity for use in treating a variety of diseases back on Earth.
A randomized controlled trial of 2,275 women in Kenya showed that a single dose of the HPV vaccine was highly effective. The current standard for women is three doses. This news could greatly hasten the pace of vaccinations and brings renewed energy to make cervical cancer the first cancer to be wiped out.
A team led by the UW developed a chatbot that could ask emergency department visitors about social needs, including housing, food, access to medical care and physical safety.
Press conferences at the 181st Meeting of the Acoustical Society of America will be held Wednesday, Dec. 1, in room 505 at the Hyatt Regency Seattle. The media availabilities will focus on wide range of newsworthy sessions at the upcoming meeting from killer whales spending more time in the Arctic Ocean to knocking over Lego minifigures with time reversal focused vibration. For more information, contact AIP Media.
ISPOR—The Professional Society for Health Economics and Outcomes Research (HEOR) announced its plenary speakers for Virtual ISPOR Europe 2021 scheduled for 30 November - 3 December.
More people with advanced melanoma survive for two years or more when they receive a combination of two immunotherapy drugs given before a combination of two targeted therapies, if needed, compared to people who start treatment with targeted therapies.
An implant that delivers medication to the back of the eye was found to effectively treat age-related macular degeneration (AMD) for at least six months.
A new study presented today at AAO 2021, the 125th annual meeting of the American Academy of Ophthalmology, shows that even patients with mild inflammation can experience a reduction in eye bulging with Tepezza.
A new laser-activated nanoparticle promises to target and destroy eye cancer cells and preserve vision.
New research from the University of Miami suggests the answer to dry eye may lie in the way the nervous system reacts to pain.
A new, updated risk score can help predict possible contrast-associated acute kidney injury (CA-AKI) among patients undergoing percutaneous coronary intervention (PCI), Mount Sinai researchers report.
Radiofrequency neurotomy is used to provide long-term relief for chronic neck and lower-back pain. The most common side effect is a sensation of burning, numbness, and shooting in the area where the needles were placed. This study found that steroids significantly reduce this side effect.
Researchers at Toronto Western Hospital in Canada have proposed a protocol for patients undergoing neuromodulation implantation that incorporates a short mental health checklist and pre-defined cut-offs on validated questionnaires to assess the need for an in-person assessment by a psychologist.
A new study found that kyphoplasty was less likely to be performed in Black patients, as well as in patients with dual Medicare and Medicaid eligibility, who tend to be lower-income older adults.
A retrospective study sought to determine demographic and clinical predictors of a successful response to dorsal root ganglion stimulation. A history of prior chronic opioid use was associated with significantly lower rates of responder status. Other characteristics such as age, gender, body mass index, and smoking showed no changes in responder status.
More than 11 million Americans experience chronic wrist pain. Percutaneous denervation, a procedure that interrupts the signal from the nerve to the brain, is emerging as a non-invasive alternative for chronic wrist pain. A recent study explored specific sites in the wrist enable effective use of this technique.
A novel drug delivery matrix currently in pre-clinical development may offer a narcotic-free alternative for patients experiencing pain after surgery.
A new study released at AAO 2021 showed that a new kind of artificial lens allowed over 90 percent of patients to see well enough that they no longer needed glasses.
New research confirms that increased screen time did lead to more eye strain in children, as well as a more troubling eye condition called convergence insufficiency, which can cause difficulty reading.
This special edition of MD Anderson's Research Highlights features presentations at the Society for Immunotherapy of Caner 36th Annual Meeting.
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