Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells’ ability to eliminate blood cancers.
A study led by The University of Texas MD Anderson Cancer Center showed that first-line treatment with a regimen of chemotherapy combined with the monoclonal antibody blinatumomab resulted in increased survival and achieved a high rate of measurable residual disease (MRD) negativity for patients who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative B-cell ALL (Ph-negative B-ALL).
Older individuals are at an increased risk of developing primary central nervous system lymphoma (PCNSL). In a retrospective study of patients with newly diagnosed PCNSL, researchers at Rutgers Cancer Institute of New Jersey and colleagues used geriatric assessments to analyze detailed characteristics, treatment, and outcomes in patients across 17 academic centers.
Today, during the ASH Annual Meeting and Exposition, Eunice Wang, MD, Chief of Leukemia and Director of Infusion Services at Roswell Park Comprehensive Cancer Center, is presenting data on two ongoing studies incorporating new treatment options for AML.
Researchers from Rutgers Cancer Institute of New Jersey evaluated the frequency of SARS-CoV-2, the virus that causes COVID-19, on various environmental surfaces in outpatient and inpatient hematology/oncology settings located within Rutgers Cancer Institute and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility. The study revealed extremely low detection of SARS-CoV-2 on environmental surfaces across multiple outpatient and inpatient oncology areas, including an active COVID-19 floor.
A new biomarker discovered by a team that includes researchers from Penn Medicine identifies patients with an aggressive form of lymphoma unlikely to respond to the targeted treatment ibrutinib.
A study led by researchers at The University of Texas MD Anderson Cancer Center found that axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is a safe and effective first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), a group with an urgent need for new and effective treatments.
The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute.
A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma.
A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.
Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don’t have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes.
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.
Investigators from Foundation Medicine, Inc. and Rutgers Cancer Institute of New Jersey, the state’s only National Cancer Institute-designated Comprehensive Cancer Center, examined genomic ancestry in BCL subtypes applying genomic ancestry prediction methodology to comprehensive genomic profiling data and found multiple genomic differences. Results of the study will be shared at the virtual American Society of Hematology Annual Meeting.
Prophylaxis & Treatment Protocols for Covid-19
The American Society of Hematology (ASH), is the world’s largest professional society with a focus on the causes and treatment of blood disorders. Experts from Rutgers Cancer Institute of New Jersey will be presenting a variety of key hematology data at the 62nd American Society of Hematology Annual Meeting. This includes 22 scheduled presentations, including 10 oral presentations examining several types of blood cancers including leukemia, lymphoma, and myeloma.
Researchers are warning of a possible link between a rare and devastating eye infection and COVID-19.
Dana-Farber Cancer Institute researchers will present more than 40 research studies at the virtual 62nd American Society of Hematology (ASH) Annual Meeting on December 5-8, including two studies that were selected for inclusion in the official press program.
In response to the critical shortage of nasopharyngeal (NP) swabs early in the COVID-19 pandemic, the Department of Radiology at University of South Florida (USF) Health in Tampa set out to design, validate and create NP swabs using a point-of-care 3D printer. Results of the first clinical trial of 3D-printed NP swabs for COVID-19 testing are being presented at the annual meeting of the Radiological Society of North America (RSNA).
Antibiotics may be a good treatment choice for some appendicitis patients, according to early results from the Comparing Outcomes of antibiotic Drugs and Appendectomy (CODA) trial reported in the New England Journal of Medicine.
ISPOR—The Professional Society for Health Economics and Outcomes Research (HEOR) announced that the on demand version of its Virtual ISPOR Europe 2020 conference is now available to registrants through 31 December 2020. ISPOR Europe is the leading European conference for HEOR.
Specifically, Dr. Susan Reed talked about research into drugs that act at the kisspeptin/neurokinin B/ dynorphin (KNDy) neuron complex in the hypothalamus which controls reproduction and hormonal control. During menopause, estrogen levels decrease, which causes these neurons to be hyperstimulated, thereby causing hot flashes.
Resuscitation and survival rates for hospitalized COVID-19 patients who have cardiac arrest are much higher than earlier reports of near-zero; variation at the individual hospital level may have affected overall numbers
Buenos Aires, Argentina 19 November 2020: Lockdown due to the COVID-19 pandemic is associated with an increase in high blood pressure among patients admitted to emergency. That's the finding of a study presented at the 46th Argentine Congress of Cardiology (SAC).
SEATTLE — Nov. 18, 2020 — Fred Hutchinson Cancer Research Center’s latest findings on cell therapies, repairing immune function, and more will be featured at the 62nd American Society of Hematology Annual Meeting & Exposition, to be held virtually Dec. 5 – 8.Dr. Stephanie Lee, ASH president and Fred Hutch physician-scientist will kick off the meeting with a fireside chat with Dr.
Members of the media can now register to cover the latest advances in hormone health and science at ENDO 2021, the Endocrine Society’s virtual annual meeting being held March 20-23, 2021 in a state-of-the-art digital platform. The virtual meeting will mirror an in-person ENDO with top-flight educational programming and networking opportunities.
Food allergies cost billions of dollars and cause enormous suffering for people. Researchers are trying to remove the source of food allergies altogether — troublesome proteins made by our favorite crops.
The Cardiovascular Research Foundation (CRF) has announced that the 2021 Chronic Total Occlusion (CTO) Summit will now take place as a virtual event called CTO Connect. It will take place online February 20-21, 2021. The conference will feature live case transmissions performed by some of the world’s leading operators along with real-time analysis from world-class faculty members. Live and on-demand sessions will also highlight engaging case-based discussions, challenging cases, and the latest technical developments and refinements in CTO PCI.
Erika L.F. Holzbaur, William Maul Measey Professor of Physiology at University of Pennsylvania Perelman School of Medicine, was chosen by the Women in Cell Biology Committee (WICB) of the American Society for Cell Biology as the recipient of the 2020 Sandra K. Masur Senior Leadership Award for her mentorship, teaching, leadership, and science.
A new American Heart Association collaborative model for COVID-19 research, using data from the new AHA COVID-19 Cardiovascular Disease Registry, found Hispanic and Black adults with COVID-19 were far more likely to be hospitalized than their white counterparts, as were people with obesity and COVID-19, according to three late-breaking research studies presented today at the American Heart Association's Scientific Sessions 2020.
The Award Selection Committee of the American Society for Cell Biology has chosen Matthew Akamatsu, the Arnold O. Beckman Postdoctoral Fellow at the University of California, Berkeley; Gwendolyn Beacham, a PhD candidate at Cornell University; and Kate Cavanaugh, a PhD candidate from University of Chicago, as the 2020 winners of the Porter Prizes for Research Excellence. Akamatsu will receive $4,000, and Cavanaugh and Beacham will each receive $2,000. Each winner will give a talk in a Minisymposium relevant to her or his research. Also recognized as Honorable Mentions are Jui-Hsia Weng, a postdoctoral researcher in the Department of Systems Biology at Harvard Medical School; and Hawa Racine, a postdoctoral research fellow in The Cell and Developmental Biology Center at the National Heart, Lung, and Blood Institute, National Institutes of Health.
Michael N. Trinh, an MD/PhD student at the University of Texas (UT) Southwestern Medical Center at Dallas, has been selected as the recipient of the Merton Bernfield Memorial Award by the American Society for Cell Biology. In the lab of Michael S. Brown and Joseph L. Goldstein, Trinh studies cellular cholesterol homeostasis using genetics and cell biology.
DALLAS – Nov. 17, 2020 – Research presented today by UT Southwestern cardiologists at the annual American Heart Association (AHA) Scientific Sessions 2020 showed that Black and Hispanic people were more likely to be hospitalized with COVID-19 than white patients, and that nonwhite men with cardiovascular disease or risk factors were more likely to die.
James Olzmann, an associate professor at University of California, Berkeley, and investigator at the Chan Zuckerberg Biohub, will give a talk on the challenging scientific frontier of “Lipid Droplet Proteome Dynamics and Regulation” at Cell Bio Virtual 2020 as this year’s winner of the Günter Blobel Early Career Award, previously the Early Career Life Scientist Award.
DALLAS – Nov. 17, 2020 – Being younger doesn’t protect against the dangers of COVID-19 if you are overweight, according to a new study from UT Southwestern. While all adults who are overweight or obese are at greater risk for serious complications from the disease, the link is strongest for those age 50 and under.
ASCB is pleased to announce that Lovell Jones, Emeritus Professor at both the University of Texas M.D. Anderson Cancer Center and the University of Texas Graduate School of Biomedical Sciences at Houston will present the 2020 E. E. Just Awards Lecture at Cell Bio Virtual 2020–an ASCB|EMBO online meeting.
The American Society for Cell Biology is pleased to announce that Jennifer Lippincott-Schwartz will present this year’s E.B. Wilson Award Lecture at Cell Bio Virtual 2020–an Online ASCB|EMBO Meeting. The talk will be presented online on December 10, 2020, at 2:30 PM - 3:15 PM ET.
People taking dummy pills and statins experienced similar side effects in a new study.
The 2020 Women in Cell Biology Mid-Career Award of the American Society for Cell Biology is being shared by Anne Carpenter, Institute Scientist and Senior Director of the Imaging Platform, Broad Institute of MIT and Harvard; and Daniela Nicastro, a professor in the Department of Cell Biology at University of Texas Southwestern (UTSW) Medical Center.
“Inclusive Science and Institutional Change” will be the title of the Diversity Keynote presented by invited speaker Sylvia Hurtado for Cell Bio Virtual 2020–an ASCB|EMBO online meeting. Hurtado is a professor in the Graduate School of Education and Information Studies at the University of California, Los Angeles (UCLA). The Diversity Keynote will premiere on December 3 at 11:45 am ET in the Cell Bio Virtual 2020 online platform.
Study finds that in a diverse, global patient population, a minimal monitoring (MINMON) approach to hepatitis C treatment was safe and achieved comparable sustained virologic response (SVR) to current standard of care.
New research confirms large breath shields protect patients and physicians against droplets which spread COVID-19.
El 14 de noviembre, durante la Reunión Científica Anual virtual, la Dra. Luz Fonacier de Mineola NY, fue instalada como presidenta del ACAAI. La Dra. Fonacier es la cuarta mujer y la primera presidenta asiático-americana de la ACAAI.
Luz Fonacier, MD, of Mineola NY, was installed as president of the American College of Allergy, Asthma and Immunology (ACAAI) at the virtual ACAAI Annual Scientific Meeting on November 15.
Research using the American Academy of Ophthalmology’s IRIS Registry to be presented at AAO 2020 Virtual.
New research presented today at the American Heart Association Scientific Sessions suggests neither vitamin D nor the omega-3 fatty acids found in fish oil prevent the development of atrial fibrillation, a potentially serious heart rhythm disturbance.
A new study being presented at this year’s virtual ACAAI Annual Scientific Meeting shows that nearly one in five parents of food-allergic kids are the target of bullying by a multitude of sources.
Data from a new study presented this week at The Liver Meeting Digital Experience® – held by the American Association for the Study of Liver Diseases – found that in 2019, more than 500,000 persons died of hepatitis B virus infection, highlighting the urgent need for universal HBV vaccination of children beginning at birth, and scaling up testing and access to care and treatment before people with the virus develop life-threatening liver cirrhosis or liver cancer.
Data from a new study presented this week at The Liver Meeting Digital Experience® – held by the American Association for the Study of Liver Diseases – found that using neural networks, a type of machine learning algorithm, is a more accurate model for predicting waitlist mortality in liver transplantation, outperforming the older model for end-stage liver disease (MELD) scoring. This advancement could lead to the development of more equitable organ allocation systems and even reduce liver transplant waitlist death rates for patients.
Data from a new study presented this week at The Liver Meeting Digital Experience® – held by the American Association for the Study of Liver Diseases – found that while neighborhood socioeconomic deprivation is associated with worse adverse long-term outcomes after liver transplant in children, improving center-specific practices can mitigate these effects for young at-risk patients.
Data from a new study presented this week at The Liver Meeting Digital Experience® – held by the American Association for the Study of Liver Diseases – found that ursodeoxycholic acid (UDCA) treatment has significant, positive results for patients with primary sclerosing cholangitis (PSC), including reduced incidence of biliary tract cancer, reduced mortality and less need for liver transplant.
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