A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new University of Liverpool research warns.
Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle. Results are being presented at the American Society of Hematology Annual Meeting.
Once rare, the superbug methicillin-resistant Staphylococcus aureus (MRSA) infects hundreds of thousands of people in the U.S. each year and kills about 20,000. New research led by Washington University School of Medicine in St. Louis sheds light on how MRSA is introduced into households and, once there, how it can spread among family members, including the furry ones. Understanding MRSA’s transmission dynamics is critical to devising effective preventive tactics.
Genes often mutate and lose their function over long-term evolution, which could be good if that stops drug resistance or cancer. A study by Stony Brook University researchers, published online in PNAS, shows that evolution can exploit positive feedback (PF) within cells to restore gene function.
After screening thousands of small molecules, the research team discovered a potent new antimicrobial they are calling MAC-545496 that is active against MRSA. Unlike conventional antibiotics, this new antimicrobial neither kills the staph infection nor halts its growth on its own, so the potential for antimicrobial resistance may be considerably lessened.
University of Wisconsin-Madison researchers examined the effects of baloxavir treatment on influenza virus samples collected from patients before and after treatment.
“We believe Beaumont has a duty to raise awareness and help change attitudes about antibiotics and behaviors that cause antibiotic resistance,” said Dr. Sam Flanders, senior vice president and chief quality and safety officer of Beaumont Health. “Antibiotics save lives. But when they’re used too much, they can lead to antibiotic resistance.”
A team of researchers at Notre Dame put out a call to the masses, enlisting researchers, data scientists and health professionals to analyze genomic data from emerging drug-resistant malaria parasites and gain a better understanding of the mechanisms of resistance.
Cornell researchers have uncovered the structure of a regulatory mechanism unique to bacteria, opening the door for designing new antibiotics targeted to pathogens.
Less than a century after the discovery of antibiotics, the world is at risk of entering an era in which the life-saving drugs no longer work.
The American Thoracic Society, Centers for Disease Control and Prevention, European Respiratory Society and the Infectious Diseases Society of America have published an official clinical guideline on the treatment of drug-resistant tuberculosis (DR-TB) in the Nov. 15 American Journal of Respiratory and Critical Care Medicine.
The Antibiotic Resistance Threats Report released by the U.S. Centers for Disease Prevention and Control today shows that while recent federal investments to combat antibiotic resistance have had meaningful impacts, the continued spread of infections that are not effectively treated by existing medicines pose deadly threats to patients and public health. As physicians and scientists on the front lines of a growing public health crisis, the Infectious Diseases Society of America urges federal policy makers to respond to the report’s warning with investments and commitment to turning the tide of antibiotic resistance.
Half of older Americans got help from the infection-fighting power of antibiotics in the past two years, a new poll finds, but a sizable minority didn’t follow the instructions on their pill bottle. And one in five say that in the past, they’ve engaged in a risky practice: taking leftover antibiotics without checking with a medical professional.
An international collaboration has identified therapy-induced, drug-resistance mutations in children with acute lymphoblastic leukemia who relapse
More than 30 million people in the United States wrongly believe they are allergic to penicillin.
With the increasing rate of multi-drug resistance, it is fundamental to identify new antibiotics. In this study, researchers found the synthesis of the vitamin biotin is integral for the growth of drug-resistant bacteria in human plasma. They were able to treat drug-resistant infections by inhibiting biotin synthesis in an infection mimicking human conditions. By inhibiting biotin synthesis, they have the potential to produce a novel class of antibiotics.
The American Dental Association (ADA) announced today a new guideline indicating that in most cases, antibiotics are not recommended for toothaches. This guidance, published in the November issue of the Journal of the American Dental Association
How bacteria live – whether as independent cells or in a communal biofilm – determines the course of their evolution, with implications for drug-resistant infections.
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