Feature Channels: Diabetes

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Last month, Lara Holmes celebrated two birthdays—her normal birthday, and the first birthday since she received the gift of a lifetime: a new pancreas and kidney.

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Researchers at The Mehandru Center for Innovation in Nephrology at Hackensack Meridian Jersey Shore University Medical Center and other authors recently had their new case report article “Metabolic Acidosis, Hyperkalemia, and Renal Unresponsiveness to Aldosterone Syndrome: Response to Treatment with Low-Potassium Diet,” published.

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Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases.

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The American Thyroid Association (ATA) celebrates the recipients of the Women Advancing Thyroid Research Award.  This award recognizes and honors the work of young women that are leading outstanding thyroid research.

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University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.

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Research being presented at the virtual 2021 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) confirms that the SARS-CoV-2 can infect ocular tissue, especially of those with diabetes, and that wearing protective eyewear could reduce transmission of COVID-19.

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New research results out of the University of Toronto indicate that one third of patients with diabetes in an urban center in Canada have not been screened for diabetic retinopathy (DR), and further, that of all patients with diabetes, young adults, immigrants and those not under the care of a family physician are at highest risk of not being screened. The study is being presented at the virtual 2021 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO).

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Researchers at the Rush Institute of Healthy Aging have found that D-CLIP, a lifestyle education program to prevent diabetes in South Asians with prediabetes increased physical activity by nearly an hour a week.

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How has the field of nutrition changed how we eat and live? What new discoveries and advances may be just over the horizon? Get the latest insights from leading nutrition scientists and practitioners at NUTRITION 2021 LIVE ONLINE, the flagship online meeting of the American Society for Nutrition.

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Researchers from Wake Forest School of Medicine in North Carolina have demonstrated that a common diabetes drug inhibits the spread of Clostridioides difficile, or C. diff—a potentially life-threatening infection commonly acquired during hospital stays. The team will present their work virtually at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2021.

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New research conducted in rats suggests a compound that gives some cruciferous vegetables their pungent taste could help to reverse kidney problems associated with diabetes.

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Donor Funded Inserra Family Diabetes Institute at Hackensack University Medical Center to Benefit Diabetes Patients and their Families

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People with type 2 diabetes tend to have poorer muscle function than others.

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In the first clinical trial of nicotinamide mononucleotide (NMN), researchers at Washington University School of Medicine in St. Louis have found that the compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people.

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The Endocrine Society is calling on Congress to pass legislation to lower the price of insulin and applauds the efforts of Energy and Commerce Committee Chairman Frank Pallone Jr. (D-NJ), Ways and Means Committee Chairman Richard E. Neal (D-MA), and Education and Labor Committee Chairman Robert C. "Bobby" Scott (D-VA) to reintroduce H.R. 3, the Elijah E. Cummings Lower Drug Costs Now Act to improve access to affordable medications. In January, the Society published a position statement on insulin access and affordability, which recommends policymakers include government negotiation as part of an overall strategy to reduce insulin prices.

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The Association of Diabetes Care & Education Specialists opened registration today for the ADCES21 Virtual Annual Conference, taking place Thursday, Aug. 12 to Sunday, Aug. 15. The four-day conference focuses on topics impacting diabetes, prediabetes and cardiometabolic care including COVID-19 management, diabetes technology and therapeutics, new models of care and self-management behaviors.

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Embargoed press materials are now available for the virtual Experimental Biology (EB) 2021 meeting, featuring cutting-edge multidisciplinary research from across the life sciences. EB 2021, to be held April 27–30, is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.

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COVID-19 patients who are overweight or obese are more likely to develop a more severe infection than patients of healthy weight, and they require oxygen and invasive mechanical ventilation more often.

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While cardiovascular disease (CVD) remains the leading cause of death globally, new research led by NYU Grossman School of Medicine and Moi University School of Medicine (Kenya) found that addressing and incorporating social determinants of health (such as poverty and social isolation) in the clinical management of blood pressure in Kenya can improve outcomes for patients with diabetes or hypertension.

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DALLAS – April 19, 2021 – Treating people with Type 2 diabetes with a new once-a-week injectable insulin therapy proved to be safe and as effective as daily insulin injections, according to the results of two international clinical trials published online today in Diabetes Care. The studies suggest that the once-weekly treatment could provide a convenient alternative to the burden of daily insulin shots for diabetes patients.

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A new study from researchers at the Perelman School of Medicine at the University of Pennsylvania found significant disparities in the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors, a class of drugs proven to treat type 2 diabetes, with usage remaining low with Black, Asian, and lower-income groups despite an increase in overall usage for patients with type 2 diabetes.

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Researchers with the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine and Vertex Pharmaceuticals Incorporated have initiated clinical trials for VX-880, a novel investigational cell therapy with the potential to restore normal glucose control in people suffering from type 1 diabetes with severe hypoglycemia and impaired hypoglycemic awareness. The University of Miami Health System was the first clinical site activated for this trial.

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A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism >on 12 March 2021, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) -- a protein known to sense noxious stimuli, including pain and temperature.

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New medicines for people who have diabetes seem to pop up all the time. Drugs that help the body break down carbohydrates, drugs that increase excretion of glucose in the urine, drugs that help muscles respond to insulin and drugs that stimulate the pancreas to produce it — the list of pharmaceutical options to treat diabetes gets longer and longer.

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No more worries for diabetics with weak muscles. The Metallurgy and Materials Science Research Institute, Chulalongkorn University will soon launch a cutting-edge, health innovation – a wristwatch that can check blood sugar levels from sweat in real-time. It’s accurate, not painful, less expensive, and can replace imported equipment. It is expected to be available on the market soon.

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While it has already been established that those with Type II diabetes and a high body mass index (BMI) are at greater risk of experiencing hospitalizations and other severe complications related to COVID-19, they are also at greater risk of getting symptomatic infection in the first place.

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High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes.

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New research led by a University of Georgia faculty member in collaboration with a University of Southern California research group has shown in a rodent model that daily consumption of sugar-sweetened beverages during adolescence impairs performance on a learning and memory task during adulthood. The group further showed that changes in the bacteria in the gut may be the key to the sugar-induced memory impairment.

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Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.

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BOSTON – (March 25, 2021) – A mechanism has been identified that explains how physical exercise in pregnancy confers metabolic health benefits in offspring. According to researchers, the key lies with a protein called SOD3, vitamin D and adequate exercise, with the outcomes possibly forming the first steps to designing rational diet and exercise programs to use during pregnancy and particularly when mothers may also be overweight or obese.

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UNC School of Medicine scientists found that HIV boosts a key process in human cells to fuel its replication. They also found that the diabetes drug metformin inhibits that process and thereby suppresses HIV replication in these cells in cell lines and animal models.

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Examining data at a city level can inform more targeted local policy interventions and programming to promote health equity, find researchers.

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Incorporating sweet potato puree into bread not only adds vitamin A, but also changes the starch composition by increasing the fiber content. That can be beneficial for diabetics.

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Endocrine Society selected Hydelene Dominguez, M.D., as the first winner of the C. Wayne Bardin International Travel Award. The award was established to pay tribute to Bardin, who passed away in 2019 and made remarkable research contributions to both reproductive physiology and contraception throughout his long career.

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One in five adults with type 1 diabetes who require in-hospital treatment of the life-threatening condition diabetic ketoacidosis has an unplanned repeat hospital visit within a month and is twice as likely to die during the second hospitalization, a new study finds. The results, which will be presented at ENDO 2021, the Endocrine Society’s annual meeting, also identified several factors that increased the readmission risk for these patients.

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A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society’s annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes.

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Some patients with moderate to severe COVID-19 disease seem to experience inflammation of the thyroid gland that is different from thyroid inflammation caused by other viruses, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

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Children with poorly controlled type 1 diabetes have a 10 times higher risk of COVID-19-related complications and death compared to those with well-controlled diabetes, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

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Commonly used medications for type 2 diabetes and obesity called glucagon like peptide-1 receptor agonists (GLP-1 RAs), are not associated with an increased risk of breast cancer, despite previous studies that suggested a possible link, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

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New genetic research suggests men can develop characteristics of polycystic ovary syndrome (PCOS)—a common metabolic and reproductive disorder that affects women. The study was presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

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People with type 1 diabetes can improve their blood sugar control while reducing time with low blood sugar, or hypoglycemia, using Insulet Corporation’s Omnipod 5 Automated Insulin Delivery System compared to their standard insulin therapy. Results from an industry-sponsored study of the latest Omnipod, the first tubeless, wearable insulin pump, will be presented at ENDO 2021, the Endocrine Society’s annual meeting.

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Blood glucose levels improved among children and teens with type 1 diabetes during the first 12 weeks of COVID-19 lockdown in the United Kingdom, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

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Treatment of hypothyroidism, which results from an underactive thyroid gland, should be individualized and consideration should be given to alternatives to the first-line therapy, including desiccated thyroid extract and combination therapy to replace the body’s two main thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Results of their new randomized clinical study are being presented at ENDO 2021, the Endocrine Society’s annual meeting.

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Black women with polycystic ovary syndrome (PCOS) have higher risk factors for heart disease, diabetes and stroke compared with white women, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

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Among women who develop diabetes during pregnancy, night owls have a higher risk of complications for mother and baby than early birds do, according to a study whose results will be presented at ENDO 2021, the Endocrine Society’s annual meeting.

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Two-thirds of patients with chronic endocrine health problems who need close monitoring say they would like to continue with telemedicine follow-up visits after the COVID-19 pandemic ends, according to a survey that will be presented virtually at ENDO 2021, the Endocrine Society’s annual meeting. Three-quarters of providers also said they want to continue with telehealth after the pandemic.