Scientists at The Scripps Research Institute have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.
Journal of Drugs in Dermatology (JDD) today released a clinical study highlighting the efficacy of Triple Protection Factor Broad Spectrum Sunscreen, TPF 50, to prevent skin sun damage and Non-Melanoma Skin Cancer (NMSC). In this head-to-head comparison study, investigators Enzo Emanuele MD, PhD, James M. Spencer MD, MS and Martin Braun MD found that TPF50 was more effective than both the main DNA repair and AO existing products.
Whitehead Institute scientists have used a yeast cell-based drug screen to identify a class of molecules that target the amyloid-β (Aβ) peptide involved in Alzheimer’s disease (AD).
Honey, that delectable condiment for breads and fruits, could be one sweet solution to the serious, ever-growing problem of bacterial resistance to antibiotics, researchers said here today. Their study was part of the 247th National Meeting of the American Chemical Society, the world’s largest scientific society.
As some countries and companies roll out new rules to limit animal testing in pharmaceutical products designed for people, scientists are stepping in with a new way to test therapeutic drug candidates and determine drug safety and drug interactions — without using animals. The development of “chemosynthetic livers,” which could dramatically alter how drugs are made, was presented at the 247th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
Scientists reported today on at least five new experimental substances — based on a tiny protein found in cone snail venom — that could someday lead to the development of safe and effective oral medications for the treatment of chronic nerve pain. They say the substances could potentially be stronger than morphine, with fewer side effects and lower risk of abuse. They presented the research at the 247th National Meeting & Exposition of the American Chemical Society.
A color-coded smart tag could tell consumers whether milk has turned sour or green beans have spoiled without opening the containers, say researchers. The tag, appearing on the packaging, also could be used to determine if medications and other perishable products were still active or fresh. The report was presented today at the 247th National Meeting & Exposition of the American Chemical Society. A new video shows the tag in action.
In response to drug-resistant “superbugs” that send millions of people to hospitals around the world, scientists are building tiny, “molecular drill bits” that kill bacteria by bursting through their protective cell walls. They presented some of the latest developments on these drill bits, better known to scientists as antimicrobial peptides (AMPs), at the 247th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
When cancer spreads, it becomes even more deadly. It moves with stealth and can go undetected for months or years. But a new technology that uses “nano-flares” has the potential to catch these tumor cells early. Today, at the 247th National Meeting & Exposition of the American Chemical Society, scientists presented the latest advances in nano-flare technology as it applies to the detection of metastatic breast cancer cells.
Altheus Therapeutics, Inc., announced completion of dosing in ZA201, a double-blind, active-controlled Phase 2 trial evaluating the efficacy and safety of Zoenasa® Rectal Gel versus mesalamine enema in 120 patients with left-sided ulcerative colitis.
“Many lipodystrophy patients have benefited from leptin therapy. While it is not a cure, leptin does help manage complications that can include diabetes, high blood lipids, and accumulation of fat in the liver,” said Dr. Abhimanyu Garg.
A new preclinical study published online ahead of print in the Journal of Clinical Investigation from Penn Medicine researchers found that in many cases the root of resistance to BRAF inhibitors may lie in a never-before-seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib.
Opiate use triggers changes in the protein RGS9-2 in neurons in the brain's reward center. Repeated use affects analgesic relief and tolerance, as well as addiction.
New research indicates that collecting and bleeding horseshoe crabs for biomedical purposes causes short-term changes in their behavior and physiology that could exacerbate the crabs’ population decline in parts of the east coast.
A new study by scientists from the Florida campus of The Scripps Research Institute has uncovered a mechanism of drug resistance. This knowledge could have a major impact on the development of a pair of highly potent new antibiotic drug candidates.
The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to a study led by researchers at The University of Texas MD Anderson Cancer Center.
Adding bevacizumab (Avastin) to standard chemotherapy and radiation treatment does not improve survival for patients newly diagnosed with the often deadly brain cancer glioblastoma, researchers report in the Feb. 20 issue of the New England Journal of Medicine.
A team of researchers at City of Hope has developed a screening assay that can quickly assess up to 1,536 compounds’ effect on estrogen activity in the body. The test can also evaluate whether chemicals act as inhibitors of aromatase, an enzyme linked to breast cancer that converts androgen to estrogen.
If you're a doctor, choosing the best drug for a patient with schizophrenia isn't easy. Researchers at UNC School of Medicine are trying to help by better understanding the genetic underpinnings of drug side effects while creating a better way for geneticists to design experiments.
MMIS, a leading provider of SaaS compliance solutions for the life science industry, introduces MediSpend® Validate, an easy-to-use, self-service tool, designed to help pharmaceutical and medical device companies validate all three Federal Open Payment Reports. MediSpend® Validate fills the gap in the current transparency process.
University of Adelaide researchers have identified a key step for the future prevention of liver failure resulting from taking too much of the everyday painkiller acetaminophen (also known as paracetamol).
A group of prominent healthcare experts including bioethicists, pharmacists, policymakers and cancer specialists have proposed concrete steps for preventing and managing a nightmare scenario that is becoming all too common: shortages of life-saving drugs.
Global research overseen by and conducted at the Wayne State University School of Medicine will immediately change the treatment regimen of millions of multiple sclerosis patients around the world.
/PRNewswire/ -- Altheus Therapeutics, Inc. announced the USPTO has allowed patent 8,629,127 B2 covering the oral pharmaceutical composition 5-ASA (5-aminosalicylic acid) and NAC (N-acetylcysteine). Combination therapy patents are uncommon and under-appreciated in the pharmaceutical industry because the Patent Office requires surprising, unexpected, or synergistic benefits from combining active ingredients into a single formulation. Altheus' success in procuring the strong and diverse patents for Zoenasa, including this most recent oral combination therapy patent, stems from rigorous studies demonstrating highly statistically significant synergy between Zoenasa's two components.
St. Jude Children’s Research Hospital scientists have discovered a promising new class of antibiotics that could aid efforts to overcome drug-resistance in tuberculosis, a global killer.
Moffitt Cancer Center researchers have laid the groundwork for a revolutionary new combination therapy for the treatment of advanced melanoma – melanoma that cannot be removed surgically or has spread to other areas of the body. The newly FDA-approved therapy, Mekinist (trametinib) in combination with Tafinlar (dabrafenib), is one of the biggest advancements in melanoma treatment in the past 30 years.
New drug, idelalisib, shows efficacy in treating patients with relapsed indolent non-Hodgkin lymphom
Scientists at the University of California, San Diego have developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound.
A new injectable material designed to deliver drug therapies and sensor technology to targeted areas within the human body is being developed by a Texas A&M University biomedical engineer who says the system can lock its payload in place and control how it is released.
Scientists at The Scripps Research Institute have demonstrated the power of a new drug discovery technique, which allows them to find—relatively quickly and cheaply—antibodies that have a desired effect on cells.
Addition of Bevacizumab to the existing standard of care was safe and showed promising overall results. The 2- and 3- year overall survival rates were 89.8 percent and 80.2 percent, respectively.
Doctors commonly recommend drug holidays, or breaks, from certain osteoporosis drugs due to the risks associated with these treatments. Yet little has been known about the ideal duration of the holidays and how best to manage patients during this time.
• A single low dose of lithium given to mice following acute kidney injury promotes kidney repair and accelerates the recovery of kidney function.
In a prime example of finding new uses for older drugs, studies in zebrafish show that a 50-year-old antipsychotic medication called perphenazine can actively combat the cells of a difficult-to-treat form of acute lymphoblastic leukemia (ALL). The drug works by turning on a cancer-suppressing enzyme called PP2A and causing malignant tumor cells to self-destruct.
University of Washington engineers hope a new type of vaccine they have shown to work in mice will one day make it cheaper and easy to manufacture on-demand vaccines for humans. Immunizations could be administered within minutes where and when a disease is breaking out.
Scientists at The Scripps Research Institute have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work.
Prescribing both a stimulant and an antipsychotic drug to children with physical aggression and attention-deficit/hyperactivity disorder (ADHD), along with teaching parents to use behavior management techniques, reduces aggressive and serious behavioral problems in the children, according to esearchers at The Ohio State University Wexner Medical Center.
A new Scientific Statement issued today by The Endocrine Society represents a comprehensive evaluation of available information on the prevalence and medical consequences of the use of performance-enhancing drugs (PEDs). The statement highlights the clinical pharmacology, adverse effects and detection of many substances often classified as PEDs, identifies gaps in knowledge and aims to focus the attention of the medical community and policymakers on PED use as an important public health problem.
The methods used to anesthetize prostate cancer patients and control pain when their prostate glands are surgically removed for adenocarcinoma may affect their long-term cancer outcomes, a study led by Mayo Clinic has found.
In a nationwide study of women with “triple-negative” breast cancer, adding the chemotherapy drug carboplatin or the angiogenesis inhibitor Avastin to standard chemotherapy drugs brought a sharp increase in the number of patients whose tumors shrank away completely, investigators will report at the 2013 San Antonio Breast Cancer Symposium.
Common breast cancer treatments target tumors by blocking or reducing the levels of estrogen in the body. These treatments may be rendered ineffective in patients with high cholesterol, where tumors can rely on the estrogen-mimicking molecule 27HC as an alternative fuel source.
Widely used treatments for type 2 diabetes have different effects on the hearts of men and women, even as the drugs control blood sugar equally well in both sexes, according to researchers at Washington University School of Medicine in St. Louis. The investigators used PET scans to measure heart and whole-body metabolism in patients taking common diabetes drugs.
A remarkable 98.7 percent of certain lower-risk breast cancer patients were cancer free for at least three years after taking a combination of the drugs Herceptin and Taxol, a study has found.
Exercise can benefit health and improve mood, and now new research shows that it has the potential to restore sexual desire and function in women adversely affected by sexual side effects related to antidepressant use.
Imetelstat, a novel telomerase inhibiting drug, has been found to induce morphologic, molecular and clinical remissions in some patients with myelofibrosis a Mayo Clinic study has found. The results were presented today at the 2013 American Society of Hematology Annual Meeting in New Orleans.
Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue. The findings are the latest from the St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project and appear in the December 9 edition of the scientific journal Cancer Cell.
In nearly one-third of patients with Waldenstrom’s Macroglobulinemia, a specific genetic mutation switches on the disease, and a new drug that blocks the defective gene can arrest the disease in animal models, researchers at Dana-Farber Cancer Institute and allied institutions will report at the 2013 annual meeting of the American Society of Hematology (ASH). The finding may open the way to clinical trials of the drug in Waldenstrom’s patients whose tumor cells carry the mutation.
The clinical context of the administration and dosage of antipsychotics may influence their efficacy, reported Philippe Vincent and Édouard Kouassi, from the Institut universitaire en santé mentale de Montréal and Université de Montréal.
Researchers at Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology, Boston Children’s Hospital, and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma, the leading cause of irreversible blindness worldwide.
Adding bortezomib (Velcade) to standard preventive therapy for graft-versus-host-disease (GVHD) results in improved outcomes for patients receiving stem-cell transplants from mismatched and unrelated donors, according to researchers from Dana-Farber Cancer Institute.
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