Feature Channels: Alzheimer's and Dementia

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The National Institutes of Health (NIH) awarded a $10.7 million five-year renewal grant to Cleveland Clinic to expand a national research consortium focused on improving the diagnosis and treatments for Dementia with Lewy Bodies. The Dementia with Lewy Bodies Consortium, established in 2017, centralized research efforts and created a national, coordinated registry for clinical data.

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A world-first study from the University of South Australia’s Australian Centre for Precision Health has found a link between metabolism and dementia-related brain measures, providing valuable insights about the disease.

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High blood pressure means faster slide into signs of dementia or Alzheimer’s, but does not explain the overall disparity between Hispanic/Latino people and non-Hispanic people in dementia risk.

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Here are some of the latest articles that have been posted in the Guns and Violence channel on Newswise.

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The Alzheimer's Association, through its Part the Cloud global research grant program, has awarded Wake Forest University School of Medicine $795,000 over two years to study potential treatments for Alzheimer's disease.

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In a study publishing in Nature Medicine on September 22, 2022, University of California San Francisco researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD, combined and harmonized clinical, neuroimaging, and fluid biomarkers from nearly all familial FTD clinical research participants across North America and Europe. With that data, they developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.

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Irvine, Calif., Sept. 20, 2022 — What began with a $70,000 philanthropic gift 12 years ago has grown into the recipient of a $47 million National Institute on Aging grant for Alzheimer’s disease research at the University of California, Irvine. The funds will be parceled out over five years to a UCI team developing the next generation of mouse models for studying late-onset Alzheimer’s.

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People who experience frequent bad dreams in middle age are more likely to be diagnosed with dementia later in life, according to research at the University of Birmingham.

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The National Prion Disease Pathology Surveillance Center (NPDPSC) at Case Western Reserve University will receive up to $20 million in funding as part of a grant renewal from the Centers for Disease Control and Prevention (CDC) to better understand how and why prion diseases––degenerative brain conditions found in both humans and animals—develop and spread.

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Researchers are working to develop nanocarriers that deliver drugs across the blood brain barrier. Successful nanocarriers could lead to treatments for brain disorders including Alzheimer's disease, Parkinson’s disease, ischemic stroke, epilepsy and seizures.

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Being in “poor health” is far more than just a saying, according to a new University of Michigan study. In fact, adults’ risk of serious financial problems rises directly with the number of chronic health conditions they have, the study of medical and financial data from nearly 3 million privately insured adults finds.

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A UC San Diego study identifies neural mechanisms contributing to poorer cognition in aging adults; results may inspire new clinical interventions

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A combination of seven healthy lifestyle habits including sleeping seven to nine hours daily, exercising regularly and having frequent social contact was associated with a lower risk of dementia in people with type 2 diabetes, according to a study published in the September 14, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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The Cedars-Sinai Department of Computational Biomedicine has received an $8 million grant from the National Institutes of Health to study Alzheimer’s disease.

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New research from Wake Forest University School of Medicine shows that taking a daily supplement may improve cognition in older adults. In the study, researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline (about 1.8 years).

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Older people who were infected with COVID-19 show a substantially higher risk—as much as 50% to 80% higher than a control group—of developing Alzheimer’s disease within a year, according to a study of more than 6 million patients 65 and older.

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Según los investigadores de Mayo Clinic, las mujeres con antecedentes de preeclampsia grave tienen más indicadores de un mayor riesgo de sufrir daño e inflamación en las células del cerebro en comparación con aquellas que tuvieron embarazos sin complicaciones.

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Pesquisadores da Mayo Clinic descobriram que mulheres com histórico de pré-eclâmpsia grave têm mais indicadores de maior risco de danos e inflamação das células cerebrais em comparação com mulheres que tiveram gestações sem complicações.

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One of the most upsetting aspects of age-related memory decline is not being able to remember the face that accompanies the name of a person you just talked with hours earlier.

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A newly developed agonistic antibody reduced the amyloid pathology in mice with Alzheimer’s disease, signaling its promise as a potential treatment for the disease, according to a team of researchers at UTHealth Houston.

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A team of researchers at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) has been awarded a $20.5 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH). The P01 award exemplifies team science, helping to support about 35 researchers across six different labs who will be working on four main projects, all with a common theme.

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Irvine, Calif., Sept. 1, 2022 – Anxiety, autism, schizophrenia and Tourette syndrome each have their own distinguishing characteristics, but one factor bridging these and most other mental disorders is circadian rhythm disruption, according to a team of neuroscience, pharmaceutical sciences and computer science researchers at the University of California, Irvine.

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Ochsner Health neuropsychologist John Sawyer, MD, is available to offer comment on Alzheimer’s disease and cognitive and memory disorders.

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根据世界卫生组织的数据，全球有超过5500万人患有不同程度的痴呆症。Ronald Petersen（医学博士）认为，痴呆症虽然无法预防，但有办法降低患病风险。Petersen博士是一名神经科医生，兼任妙佑医疗国际阿尔茨海默氏症研究中心主任。

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Acredita-se que mais de 55 milhões de pessoas em todo o mundo vivam com demência, de acordo com a Organização Mundial da Saúde. O Dr. Ronald Petersen, neurologista e diretor do Centro de Pesquisa da Doença de Alzheimer da Mayo Clinic, diz que não é possível evitar a demência, mas que é possível reduzir o risco.

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According to the Alzheimer’s Association, an estimated 6.5 million Americans aged 65 and older are living with Alzheimer’s in 2022. That figure is predicted to nearly double by 2050.

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Patients sing and dance with their caregivers to songs from patients’ youth

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Researchers from Florida Atlantic University, in collaboration with Tel Aviv University, have received a two-year, $379,177 grant from the National Institute on Aging, National Institutes for Health, on a collaborative project to study mood-disorders changes in Alzheimer’s disease.

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Penn State College of Medicine received a $1.6 million grant from the National Institutes of Health will support research into whether COVID-19 contributes to the development of cognitive decline.

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De acuerdo con la Organización Mundial de la Salud, se cree que más de 55 millones de personas en todo el mundo viven con demencia. El Dr. Ronald Petersen, neurólogo y director del Centro de Investigación para la Enfermedad de Alzheimer en Mayo Clinic, indica que aunque no sea posible prevenir la demencia, sí se puede reducir el riesgo de padecerla.

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More than 55 million people worldwide are believed to be living with dementia, according to the World Health Organization. Ronald Petersen, M.D., a neurologist and director of Mayo Clinic’s Alzheimer’s Disease Research Center, says you can’t prevent dementia, but you can reduce your risk.

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Researchers at Washington University School of Medicine in St. Louis have found a new druggable pathway that potentially could be used to help prevent Alzheimer’s dementia.

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Adults aged 60 and older who sit for long periods watching TV or other such passive, sedentary behaviors may be at increased risk of developing dementia, according to a new study by USC and University of Arizona researchers.

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A study that assessed the brains of 99 World Trade Center (WTC) responders showed that WTC responders with cognitive impairment (CI) and post-traumatic stress disorder (PTSD) have a different presentation of the white matter in their brains compared to responders with CI without PTSD.

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A new MIT study finds that Alzheimer’s disease disrupts at least one form of visual memory by degrading a newly identified circuit that connects the vision processing centers of each brain hemisphere.

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Linda J. Van Eldik, Ph.D., director of the University of Kentucky Sanders-Brown Center on Aging, is part of a $1.5 million grant to help further research into a possible treatment for Alzheimer’s disease. A four-year grant from the National Institute on Aging of the National Institutes of Health to Northwestern University includes a $611,676 subaward to UK. Van Eldik, the Dr. E. Vernon Smith and Eloise C. Smith Alzheimer's Research Endowed Chair, serves as principal investigator on UK’s award.

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Researchers at the University of Illinois Chicago have discovered that increasing the production of new neurons in mice with Alzheimer’s disease (AD) rescues the animals’ memory defects. The study, to be published August 19 in the Journal of Experimental Medicine (JEM), shows that new neurons can incorporate into the neural circuits that store memories and restore their normal function, suggesting that boosting neuron production could be a viable strategy to treat AD patients.

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A new UCLA-led study has identified multiple new risk genes for Alzheimer’s disease and a rare, related brain disorder by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment. 

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In the recent popular Korean TV series “The Light in Your Eyes,” many viewers emphasized with the main character suffering from Alzheimer’s disease.

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UC San Diego researchers received a $1.3 million grant from the Keck Foundation for a project that could help scientists better understand the role misfolded tau proteins play in causing neurodegenerative diseases like dementia, which may lead to more effective drug therapies.

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Scientists have demonstrated that the APOE4 gene variant, which increases risk for Alzheimer’s but decreases risk of glaucoma in humans, blocks a disease cascade that leads to the destruction of retinal ganglion cells in glaucoma. Additionally, they showed in mouse models that the death of retinal ganglion cells – the cause of vision loss in glaucoma – can be prevented by using medications to inhibit a molecule called Galectin-3, which is regulated by the APOE gene. These findings taken together emphasize the critical role of APOE in glaucoma and suggest that Galectin-3 inhibitors hold promise as a glaucoma treatment, according to the authors.