Feature Channels: Alzheimer's and Dementia

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交谈困难或记忆和思维能力出现问题的人可能需要进行听力检查。神经科医生兼妙佑医疗国际阿尔茨海默氏症研究中心主任Ronald Petersen（医学博士）解释道，与年龄相关的听力减退可能会增加认知功能下降的风险。

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Las personas que tienen dificultad para seguir una conversación o desarrollan problemas con las capacidades de la memoria y el pensamiento deberían hacerse revisar la audición.

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A multisite research team from the University of California, Irvine, the University of Wisconsin–Madison and Wake Forest University has discovered that brain inflammation may link Alzheimer’s disease risk with sleep disturbance, which may aid early detection and prevention efforts by identifying novel treatment targets at preclinical stages.

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New research published in the journal Frontiers in Aging Neuroscience by Tufts University scientists and colleagues suggests a link between Fusobacterium nucleatum (F. nucleatum), a common type of bacteria that proliferates in periodontal disease, and Alzheimer’s disease.

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To build a resource that greatly expands Alzheimer’s disease genetic studies in the currently underrepresented African ancestry populations and Hispanic/Latinx groups, the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami Miller School of Medicine will lead a major five-year, international, multi-site initiative with Case Western Reserve University, Columbia University, Wake Forest University, the University of Pennsylvania, and the University of Ibadan, which is the lead institution for the African Dementia Consortium (AfDC).

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New research led by the University of South Australia shows that fatty foods may not only be adding to your waistline but also aggravating Alzheimer's disease, and causing depression and anxiety.

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Areas of the brain vulnerable to neurodegenerative disorders like Alzheimer’s disease tend to have less dense vascular networks — which supply the brain with energy via blood — than other areas of the brain, according to Penn State researchers.

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Older people with hypothyroidism, also called underactive thyroid, may be at increased risk of developing dementia, according to a study published in the July 6, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The risk of developing dementia was even higher for people whose thyroid condition required thyroid hormone replacement medication.

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A University of Minnesota Twin Cities-led team has developed a new technique for imaging mRNA molecules in the brains of living mice. The research reveals new insights into how memories are formed and stored in the brain and could allow scientists to learn more about diseases such as Alzheimer’s in the future.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer’s; the most well-known of these for people over the age of 65 is the APOE ε4 allele.

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An optical fiber as thin as a strand of hair holds promise for use in minimally invasive deep-tissue studies of patients' brains that show the effects Alzheimer's disease and other brain disorders. The challenge is efficiently increasing image resolution at the subcellular level, because loss of information is inevitable from light scrambling. In APL Photonics, researchers in the Netherlands address this challenge with speckle-based compressive imaging that exploits the light scrambling of multimode fibers to their advantage.

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A new biomedical research tool that enables scientists to measure hundreds of functional proteins in a single cell could offer new insights into cell machinery. Details about the cyclic microchip assay method are published in the journal Nature Communications.

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Medicare could waste up to $605 million per year on the controversial Alzheimer’s drug aducanumab if it is eventually approved for widespread use because it is supplied in vials containing fixed doses that may not be appropriate for all patients–resulting in the trashing of large volumes of unused drug

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Clemson University is seeking healthy older adults to volunteer for the Preventing Alzheimer’s with Cognitive Training (PACT) study. This landmark study examines whether computerized brain training exercises can reduce the risk of cognitive impairment and dementia such as Alzheimer’s disease.

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People who received at least one influenza vaccine were 40% less likely than their non-vaccinated peers to develop Alzheimer’s disease over the course of four years, according to a new study from UTHealth Houston.

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An important new study of diverse communities is looking at how brain changes, genetics and other factors contribute to dementia and Alzheimer’s disease. The results could affect millions. Among people 65 and older, about 1 in 9 has Alzheimer’s disease.

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Nearly 3 in 10 Americans (28%) say insomnia has a negative impact on their daily lives, according to a new survey from the AASM. On June 21, Insomnia Awareness Night will drive awareness about chronic insomnia and discuss healthy ways to treat it.

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As one of the countries with a rapidly increasing aging population, especially this 2022, Thailand is now becoming an ‘aging’ society and will likely become a ‘super-aging society’ by 2031. To better meet the needs and provide services to the nation’s aging society, experts from various fields at Chulalongkorn University have conducted research to produce and develop innovations for the elderly.

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Here are some of the latest articles that have been added to the Aging channel on Newswise, a free source for journalists.

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Two new studies offer insights into the factors that may contribute to the disproportionate burden of dementia in non-White and low-income U.S. populations.

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A world-first study from the University of South Australia could make this a reality as new genetic research shows a direct link between dementia and a lack of vitamin D.

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Researchers from the University of Kentucky’s Sanders-Brown Center on Aging say a paper recently published in Acta Neuropathologica is the most definitive assessment yet of the prevalence of a form of dementia classified in 2019 and now known as LATE. The results show that the prevalence of brain changes from LATE may be roughly 40% in older adults and as high as 50% in people with Alzheimer’s disease.

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A new analysis led by researchers with the University of California has found the top threats to Americans today regarding dementia in old age are obesity, physical inactivity, and lack of a high school diploma.

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Shingles, a viral infection caused by the reactivation of the chickenpox virus, results in a painful blistering rash along one side of the body or face from nerve inflammation. There has been scientific speculation that such inflammation may increase a person’s risk of dementia. However, a new study has found that shingles is not associated with an increased risk of dementia. The study is published in the June 8, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Social isolation is linked to lower brain volume in areas related to cognition and a higher risk of dementia, according to research published in the June 8, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study found that social isolation was linked to a 26% increased risk of dementia, separately from risk factors like depression and loneliness.

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Dementia Day Center, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society prepares for Thailand’s anticipated aging society by offering various rehabilitation services to help slow down the decline of people with dementia, while planning to launch a professional course for caregivers, and establishing the “Bright Brain Club” to persuade people of all ages to learn and care for early brain health to avoid the possibility Alzheimer’s disease.

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Irvine, Calif., June 7, 2022 — The University of California, Irvine has been awarded a five-year, $14 million grant from the National Institutes of Health to study brain circuits that are susceptible to aging and Alzheimer’s disease. The research findings will advance the development of early diagnostic tools and the discovery of new treatment strategies.

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While the hospice program was originally designed for patients with cancer, who are expected to die within six months, currently close to half of older adult hospice enrollees have a diagnosis of dementia.

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A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimer’s disease, a new study in mice shows.

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Investigators at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that is responsible for regulating the body's response to central nervous system (CNS) disorders such as Alzheimer’s, Huntington's disease and spinal cord injuries.

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Researchers at UC San Diego have received a $25.6 million grant from the National Institutes of Health and National Institute on Aging to continue the Study of Latinos-Investigation of Neurocognitive Aging, a 12-year assessment of cognitive and brain aging and impairment among aging Latinos.

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Harrington Discovery Institute at University Hospitals and the Alzheimer's Drug Discovery Foundation (ADDF) announce a joint request for proposals for the 2022 ADDF-Harrington Scholar Award. The ADDF-Harrington Scholar Award is designed to accelerate the translation of innovative research that could treat, prevent, or slow Alzheimer's disease or related dementias. The Request for Proposal (RFP) is open to academic investigators at accredited medical centers, research institutions, and universities in the United States, Canada, and the United Kingdom. Researchers working on drug development programs that are relevant to, but not presently focused on, the Alzheimer’s field are also encouraged to apply. This award provides a combination of financial support and expert drug development guidance to provide the best chance to move research beyond the bench to the bedside.

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Medicare costs around the time of a dementia diagnosis are much lower for older adults screened proactively rather than those diagnosed while experiencing a health issue.

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A decade-long effort to reduce medication risks for nursing home residents with dementia has paid off in some ways – but produced unintended consequences that now need addressing, new research shows.

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Seven healthy habits and lifestyle factors may play a role in lowering the risk of dementia in people with the highest genetic risk, according to research published in the May 25, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer’s disease. If further research confirms the finding, the molecule, known as a glycan, could serve as a new target for early diagnostic tests, treatments and perhaps prevention of Alzheimer’s disease, say the researchers.

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UCLA scientists have discovered how the brain links memories and a way to restore this function in aging mice--as well as an FDA-approved drug that achieves the same thing. The Nature findings suggest a new method for combatting middle-aged memory loss.