Researchers have found a small molecule enzyme inhibitor capable of manipulating an immune process that plays an important role in cancers and autoimmune diseases.
The next frontier in individualized medicine is here. Mayo Clinic's 11th annual Individualizing Medicine Conference on Nov. 2–3 will focus on "Exploring the Exposome" — the cumulative measure of environmental influences and associated biological responses throughout the life span of a person, and how those exposures relate to health and disease.
Microglia are a type of immune cell that works as a ‘janitor’ to the central nervous system that clears out dead cells and other debris.
If in fact there is or has been life on Mars, it would likely still be there today, billions of years later, according to a new study published Oct. 25 in Astrobiology led by the Uniformed Services University of the Health Sciences (USU).
A new approach to cancer immunotherapy that uses one type of immune cell to kill another—rather than directly attacking the cancer—provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York. The findings were published October 11, 2022 in the journal Cancer Immunology Research [https://doi.org/10.1158/2326-6066.CIR-21-1075]. The study involved a twist on a type of therapy that uses immune cells known as CAR T cells. CAR T cells in current clinical use are engineered to recognize cancer cells directly and have successfully treated several blood cancers. But there have been challenges that prevent their effective use in many solid tumors.
A Rice University lab is leading the effort to reveal potential threats to the efficacy and safety of therapies based on CRISPR-Cas9, the Nobel Prize-winning gene editing technique, even when it appears to be working as planned.
In most higher organisms, including humans, every cell carries two versions of each gene, which are referred to as alleles.
Exposure in utero to the flame retardant FireMaster® 550 (FM 550), or to its individual brominated (BFR) or organophosphate ester (OPFR) components, resulted in altered brain development in newborn rats.
Chronic heart failure causes the cell’s powerhouses to dysfunction, in part due to overconsumption of an important intermediary compound in energy production.
Dysregulation of macrophages during SARS-CoV-2 infection and the over-exuberant production of pro-inflammatory cytokines by these macrophages has been hypothesized to contribute to severity of COVID-19 disease.
The University of California, Irvine today announced an endowment from Estée Lauder to establish an epigenetics fellowship in honor of the late Paolo Sassone-Corsi, Ph.D., who was UCI’s Donald Bren Professor of Biological Chemistry and director of the campus’s Center for Epigenetics and Metabolism.
The American Society for Cell Biology (ASCB) is pleased to announce that it has begun a partnership with Multiview, the largest digital publisher and marketing provider for associations, to enhance the content and reach of Pathways, ASCB’s email newsbrief.
Recent studies have shown that liquid-liquid phase separation – akin to how oil droplets form in water – leads to formation of diverse types of membraneless organelles, such as stress granules and nucleoli, in living cells.
The development of molecular biology and biotechnologies made it possible to create a lot of biosensors and diagnostic tests – from fast analyses on COVID-19 to express-tests on pathogens, striking agricultural plants. Scientists from The Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences created a platform DIRECT2, that can give birth to new-generation express tests on the base of system CRISPR-Cas12, and demonstrated its work on the example of DNA Dickeya solani – a bacterium, that harms agricultural plants.
A paper in Cell Reports Medicine details the efficacy of H84T-BanLec against all known human-infecting coronaviruses, including MERS, the original SARS, and SARS-CoV2, including the omicron variant.
New research facility expansion opens in Northeast Ohio at University Hospitals Seidman Cancer Center
A team led by researchers at Beth Israel Deaconess Medical Center are joining the NIH to develop a framework for mapping the human body cell by cell.
The process of metastasis is when cancer cells gain motility and spread to other sites of the body.
Scientists have long been fascinated with the origin of life on Earth, namely the transition from simple pre-biotic organic molecules to living cell systems.
Pathological processes are usually characterised by altered gene activity in the cells affected. So, gaining an accurate picture of gene activity can provide the key to the development of new, targeted therapies.
The classic view of pain is that it protects by detecting and signaling the presence of harmful agents, but new research shows pain can shield the gut more directly. Experiments in mice show that activated pain neurons induce intestinal cells to release mucus that coats and protects the intestine both under normal conditions and during inflammation. The findings raise concerns about long-term use of certain medications that suppress protective pain signaling in conditions such as colitis and migraine.
The October issue of SLAS Technology is now available Open Access on ScienceDirect.
With a newly developed technology, scientists can engineer cells to produce oxygen on demand in response to an added chemical
Optical tweezers (OTs), also known as optical traps, are highly focused laser beams that can be used to trap and manipulate microscopic objects with a noncontact force.
Researchers have identified a promising strategy for development of broad-spectrum antiviral therapies that centers around promoting a strong immune response capable of stopping a number of viruses in their infectious tracks.
Unparalleled insights into the secret life of Streptococcus pneumoniae, the bacterium responsible for hundreds of thousands of infant deaths each year, have been revealed by new research from the Wellcome Sanger Institute, the University of Oxford, the Shoklo Malaria Research Unit and Imperial College London.
By: Bill Wellock | Published: October 10, 2022 | 1:11 pm | SHARE: More than 264,000 people are diagnosed with breast cancer every year in the United States. Although deaths from breast cancer have declined over time, it remains the second-leading cause of cancer death among women.October is Breast Cancer Awareness Month, an opportunity to focus on the impact of this disease.
Moffitt Cancer Center researchers wanted to determine how PERK activity impacts the clinical outcomes of patients with melanoma. Their results are published in a new article in Cancer Cell.
Investigators from Rutgers Cancer Institute of New Jersey examined the microbiome of pancreatic tumors and identified particular microorganisms at single-cell resolution that are associated with inflammation and with poor survival. According to the researchers, these microorganisms may be new targets for earlier diagnosis or treatment of pancreatic cancer.
Scientists are working to bioengineer a defense mechanism that most plants develop naturally to protect against drought, insects and other environmental stresses. The goal is to create a roadmap for breeding plants with designer cuticles to respond to changing climates.
FASEB is now accepting nominations for its 2023 Excellence in Science Awards.
Facing extreme conditions such as starvation and stress, some bacterial cells enter a dormant state in which life processes stop. Biologists have discovered how they assess environmental conditions for a return to life, carrying implications for evaluating life on Earth as well as other planets.
Russian scientists acquired stable and bright fluorescent protein moxSAASoti, which can change color and intensity of its fluorescence. To achieve this aim, the scientists made point changes in the sequence of the coding gene.
In one of the largest single-center COVID-19 cohort studies to date, researchers at the Icahn School of Medicine at Mount Sinai, using samples collected during the peak of the pandemic in New York City, have identified a key driver of COVID-19 disease severity.
The Association for Molecular Pathology (AMP), the premier global, molecular diagnostics professional society, today announced the recipients of this year’s Award for Excellence in Molecular Diagnostics, Jeffrey A. Kant Leadership Award and Meritorious Service Award. These prestigious accolades will be presented this November during AMP’s 2022 Annual Meeting & Expo in Phoenix, Arizona.
The new cell-free protein crystallization (CFPC) method developed by Tokyo Tech includes direct protein crystallization and is a major headway in the field of structural biology.
An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests. The findings, published in PNAS, could eventually lead to new treatments for a variety of diseases.
Each day, millions of biological processes occur in our body at a cellular level. Studying these processes can help us learn more about how cells function, a field that has continued to intrigue researchers.
“I'm a professional pin-in-a-haystack seeker,” geneticist Thijn Brummelkamp responds when asked why he excels at tracking down proteins and genes that other people did not find, despite the fact that some have managed to remain elusive for as long as forty years.
“What our work shows is how a complex in the center of the cell, the ER-Golgi interaction region, controls plasma membrane cholesterol, which is essential for many cellular functions, if not essential for multicellular life,” says Professor Gisou van der Goot at EPFL’s School of Life Sciences.
Distinguished Professor Emeritus Erkki Ruoslahti, M.D., Ph.D., has been announced as one of three winners of the Albert Lasker Basic Medical Research Award, the most prestigious American award for biomedical research, for his transformational research leading to the discovery of the cell adhesion receptors now known as integrins.
University of Virginia School of Medicine researchers and their collaborators have solved a decades-old mystery about how E. coli and other bacteria are able to move.
FASEB joins alliance of organizations to identify, articulate, and advance open science, open data, and open scholarship norms and practices within their disciplines.
Scientists find three biological benefits to group swimming of sperm when navigating the female reproductive tract that may also inform studies on infertility.
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Though well-known as a respiratory illness, COVID-19 can also affect the nervous system. Now, researchers reporting in ACS Infectious Diseases have developed a new tool and possible vaccine candidate that could help scientists understand how SARS-CoV-2 could be invading these cells.
RNA is an important transmitter of information in our cells and serves as a blueprint for the production of proteins.
Biomedical research has long focused on certain model organisms, such as the mouse, fruit fly, and nematode worm C. elegans, partly because they’re easy to work with and partly because of their relevance to human biology. But the ocean is full of organisms that also offer an opportunity to develop new approaches to human health, and it turns out that the closest living invertebrate relative to humans is from the seas – a species of sea squirt called Botryllus schlosseri, or the star tunicate.
Rogel researchers have developed a new mathematical technique to begin to understand how a cell’s nucleus is organized. They hope this understanding will expose vulnerabilities that can be targeted to reprogram a cell to stop cancer or other diseases.
Cilia are small hair-like organelles that extend from cells and perform many functions, including motility and signaling.
University of Alberta research shows how cell membranes play a much larger role than previously understood in allowing spike proteins on viruses to infect cells.
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