Newswise — The July 2024 issue of Toxicological Sciences includes a Contemporary Review that discusses what is currently known about how AHR-signaling influences macrophage differentiation, polarization, and function. The issue also features an In-Depth Review that focuses on allergic reactions induced by systemically administered low-molecular weight drugs with an emphasis on drug- and patient-specific factors that could influence the development of drug hypersensitivity reactions. Additionally, a ToxSpotlight article describes a parameter grouping approach when using physiologically based kinetic models while another Tox Spotlight article explores how neonatal BDE-99 exposure may reprogram cell type–specific gene expression and cell-cell communication in the liver.
- Contemporary Review: “Mechanisms Underlying Aryl Hydrocarbon Receptor-Driven Divergent Macrophage Function” (free to read)
- In-Depth Review: “Drug Hypersensitivity Reactions: Review of the State of the Science for Prediction and Diagnosis” (open access)
- ToxSpotlight Article: “Parameter Grouping and Co-estimation in Physiologically Based Kinetic Models Using Genetic Algorithms” (open access; topic category: biotransformation, toxicokinetics, and pharmacokinetics)
- ToxSpotlight Article: “Single-Cell Transcriptomics Unveiled That Early Life BDE-99 Exposure Reprogrammed the Gut-Liver Axis to Promote a Proinflammatory Metabolic Signature in Male Mice at Late Adulthood” (free to read; topic category: environmental toxicology)
Other papers in the July 2024 issue (sorted by topic category) are:
Clinical and Translational Toxicology
“miRNAs Mediate the Impact of Smoking on Dental Pulp Stem Cells via the p53 Pathway”
Developmental and Reproductive Toxicology
“An Environmentally Relevant Mixture of Per- and Polyfluoroalkyl Substances (PFAS) Impacts Proliferation, Steroid Hormone Synthesis, and Gene Transcription in Primary Human Granulosa Cells”
“The Blood-Testis Barrier Disruption Is a Prerequisite for Toxicant-Induced Peritubular Macrophage Increases in the Testis of Peripubertal Rats” (open access)
Emerging Technologies, Methods, and Models
“Predicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs—a Proof-of-Concept Study with Doxorubicin”
Endocrine Toxicology
“House Dust-Derived Mixtures of Organophosphate Esters Alter the Phenotype, Function, Transcriptome, and Lipidome of KGN Human Ovarian Granulosa Cells”
Immunotoxicology
“The Role of Corticosterone in Nevirapine-Induced Idiosyncratic Drug-Induced Liver Injury”
Molecular, Biochemical, and Systems Toxicology
“Comparison of Transcriptomic Profiles between HFPO-DA and Prototypical PPARα, PPARγ, and Cytotoxic Agents in Mouse, Rat, and Pooled Human Hepatocytes” (open access)
Neurotoxicology
“Cadmium Inhibits Calcium Activity in Hippocampal CA1 Neurons of Freely Moving Mice”
ToxSci Volume 200, Issue #1, as well as all past issues, is available on the ToxSci website.
About Toxicological Sciences
The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology. The journal’s primary focus is on original research articles, but it also provides expert insight via contemporary, in-depth, and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field.
About the Society of Toxicology (SOT)
Founded in 1961, SOT is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of scientists who practice toxicology around the world. The Society’s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology.
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