A team of neuroscientists has identified a modification to a protein in laboratory mice linked to conditions associated with Alzheimer’s Disease. Their findings also point to a potential therapeutic intervention for alleviating memory-related disorders.
Researchers at the University of California, San Diego School of Medicine offer an explanation for why we all don't get Alzheimer's disease (AD) - a trick of nature that in most people maintains critical separation between a protein and an enzyme that, when combined, trigger the progressive cell degeneration and death characteristic of AD.
A study by Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).
Anemia, or low levels of red blood cells, may increase the risk of dementia, according to a study published in the July 31, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Glucose intolerance or insulin resistance do not appear to be associated with pathological features of Alzheimer disease (AD) or detection of the accumulation of the brain protein β-amyloid (Αβ), according to a report published by JAMA Neurology, a JAMA Network publication.
Key molecular pathways that lead to late-onset Alzheimer's disease have been identified by neuroscientists at Columbia University Medical Center. Published in Nature, findings present a new approach to Alzheimer’s research and highlight several new potential drug targets.
The trajectory of amyloid plaque buildup—clumps of abnormal proteins in the brain linked to Alzheimer’s disease—may serve as a more powerful biomarker for early detection of cognitive decline rather than using the total amount to gauge risk, researchers from Penn Medicine’s Department of Radiology suggest in a new study published online July 15 in Neurobiology of Aging.
Older people with Alzheimer’s disease are less likely to also have cancer, and older people with cancer are less likely to also have Alzheimer’s disease, according to the largest study to date on the topic, which appears in the July 10, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers in the Perelman School of Medicine at the University of Pennsylvania found that, across a variety of neurodegenerative diseases, cerebrovascular disease affecting circulation of blood in the brain was significantly associated with dementia.
The rates of regional brain loss and cognitive decline caused by aging and the early stages of Alzheimer’s disease (AD) are higher for women and for people with a key genetic risk factor for AD, say researchers at the University of California, San Diego School of Medicine in a study published online July 4 in the American Journal of Neuroradiology.
New research reveals that the likely culprit behind Alzheimer's has a different molecular structure than current drugs' target -- perhaps explaining why current medications produce little improvement in patients.
UCLA researchers have found that older adults who regularly used a brain-fitness program on a computer demonstrated significantly improved memory and language skills.
Researchers have demonstrated that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease. The findings, made in a mouse model of Alzheimer's, suggest that inhibiting this protein could prevent the neuronal damage and subsequent cognitive decline associated with the disease. The study was published this month in the online journal Nature Communications.
A chemical hormone released in the body as a reaction to stress could be a key trigger of the mechanism for the late onset of Alzheimer’s disease.
NitroMemantine is the first drug to halt the progression of synaptic loss and to even restore these connections between nerve cells. The combination drug is now headed for clinical trials.
Scientists have measured a significant and potentially pivotal difference between the brains of patients with an inherited form of Alzheimer’s disease and healthy family members who do not carry a mutation for the disease.
Multiple drug classes commonly prescribed for common medical conditions are capable of influencing the onset and progression of Alzheimer’s disease.
People afflicted with Alzheimer’s disease and other forms of dementia have a profound need for harmony and often exhibit behavioral issues when they are experiencing internal chaos. To assist caregivers—both family and professional—with creating an atmosphere of harmony, the staff at the Comprehensive Services on Aging (COPSA) Institute for Alzheimer’s Disease and Related Disorders at the University of Medicine and Dentistry of New Jersey has produced a series of free educational videos, available on the COPSAEducation YouTube channel (http://bit.ly/13YCWUD)
$1.7M NIH collaborative grant backs researchers' work on web-based WeCare, which will help caregivers better understand, assess, and treat behavioral changes in those with dementia.
People who develop a type of irregular heartbeat common in old age called atrial fibrillation may also be more likely to develop problems with memory and thinking, according to new research published in the June 5, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
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