Focus: Hidden - Ohio

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A landmark 2016 Cleveland Clinic study of widely used pain-relieving drugs showed that celecoxib (Celebrex) was associated with comparable cardiovascular safety and better gastrointestinal and kidney safety when compared with either naproxen (Naprosyn) and ibuprofen (Motrin). A new substudy, published today in the Journal of the American College of Cardiology, analyzed outcomes in PRECISION based on the presence or absence of aspirin use with specific NSAIDs (nonsteroidal anti-inflammatory drugs).

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A study by scientists at Cincinnati Children’s reports that the Epstein-Barr virus (EBV)—best known for causing mononucleosis—also increases the risks for some people of developing seven other major diseases. Published in Nature Genetics, researchers report EBV also plays a role in six other diseases: multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis, and celiac disease.

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Scientists used an experimental targeted molecular therapy to block a matrix-forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure. Researchers at the Cincinnati Children’s Heart Institute report in the journal Circulation

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Across the world, over 200 million cases of malaria and nearly 500,000 deaths from the disease occur annually—more than 90 percent of which happen in Africa. Children in Africa can be diagnosed with malaria two or three times a year, a rate that decreases as they become older and develop immunity. But the way children generate and maintain this immunity remains a mystery. Katherine Dobbs, MD, a tropical infectious diseases and malaria researcher, is conducting research in Kenya to find answers by studying white blood cells important to innate immunity, the body’s “first response” to infection.

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New research from The Ohio State University offers a glimpse into the complexity of interactions between bacteria and the viruses – or phages – that infect them.

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Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests. Researchers at Cincinnati Children’s Hospital Medical Center report their data in the journal Cell Reports. Studying mice with IPF and donated human cells, they identified a gene called FOXF1 that inhibits the IPF disease.

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Researchers from Case Western Reserve University School of Medicine and colleagues have discovered how two brain regions work together to maintain attention, and how discordance between the regions could lead to attention deficit disorders, including schizophrenia, bipolar disorder, and major depression.

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A blood test may have the potential to speed accurate diagnosis – and proper treatment – of bipolar disorder in children, new research suggests. Researchers found that children with bipolar disorder had higher blood levels of a protein associated with vitamin D compared to children without mood disorders.

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Quantum fluids may mix in very weird ways, according to new computer simulations of exotic states of matter known as Bose-Einstein condensates.

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The Ohio State University Wexner Medical Center will establish the nation’s first center dedicated to treating those with heart failure and arrhythmia with gifts totaling $18 million from Bob and Corrine Frick, who have been shadowed by heart disease for generations.

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Men on hormone therapy for prostate cancer may benefit significantly from hitting the gym with fellow patients and choosing more veggies and fewer cheeseburgers, a new study suggests.

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Rear-facing car seats have been shown to significantly reduce infant and toddler fatalities and injuries in frontal and side-impact crashes, but they’re rarely discussed in terms of rear-impact collisions. Since rear-impact crashes account for more than 25 percent of all accidents, researchers at The Ohio State University Wexner Medical Center conducted a new study to explore the effectiveness of rear-facing car seats in this scenario.

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One way to fight diseases including HIV infection and autoimmune disorders could involve changing how a naturally occurring enzyme called SAMHD1 works to influence the immune system, new research suggests.

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Leading cancer researchers, Alex Huang MD, PhD, and Yamilet Huerta, MD have been awarded $186,405 in grants from the St. Baldrick’s Foundation to conduct pediatric cancer research.

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Steven J. Allen, MD, MBA, Nationwide Children's Hospital CEO, announced his plans for retirement today, effective June 30, 2019. Allen, who will be 67 when he retires, has served since 2006, guiding Nationwide Children's Hospital through the most significant period of growth in its 126-year history. Allen will continue as CEO through the search for his successor and beyond as Emeritus Executive for Nationwide Children's Hospital following his retirement.

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Narcissists aren’t necessarily on the hunt for partners who are already in a relationship – but that doesn’t appear to stand in their way, either, new research suggests.

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Head and neck cancers (squamous cell carcinomas or HNSCC) represent more than half-a-million cases and 300,000 deaths a year, making them the sixth-leading cancer worldwide, according to the World Health Organization. A Case Western Reserve University-led research team will analyze computerized images of tissue samples for patterns which could become "biomarkers," or predictors, for determining relative risk for recurrence in one particularly common type of head and neck cancers.

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We tend to think of heroes in terms of a psychological profile: brave, altruistic, strong.But a new study suggests that for at least one kind of heroism, it takes a village to save a life.

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A Case Western Reserve University School of Medicine researcher has compiled evidence from more than 100 publications to show how obesity increases risk of 13 different cancers in young adults. The meta-analysis describes how obesity has shifted certain cancers to younger age groups, and intensified cellular mechanisms promoting the diseases.

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