Feature Channels: Genetics

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Released: 26-May-2023 11:50 AM EDT
Yeast screen uncovers genes involved in chromosomal mutation
Osaka University

When creating a computer program, errors in the code can introduce bugs to the software. Similarly, errors in our body’s genetic code, DNA, which is stored in structures known as chromosomes, can bring about mutations in the body.

Newswise: Rethinking the Protein Inhibitor Approach to Cancer Therapy
Released: 25-May-2023 12:05 PM EDT
Rethinking the Protein Inhibitor Approach to Cancer Therapy
Stony Brook University

A new method than enables researchers to dial up or tone down the amount of a certain metastatic protein inhibitor (BACH1) within a cell could provide a new path in cancer research that reassesses the effectiveness of protein inhibitors to treat disease.

Newswise: A metabolic process in cancer cells could unlock a possible treatment for glioblastoma
22-May-2023 2:40 PM EDT
A metabolic process in cancer cells could unlock a possible treatment for glioblastoma
University of California, Los Angeles (UCLA), Health Sciences

The discovery suggests that one possible approach to treat glioblastoma would be a therapy that targets the metabolic process in patients who have that genetic alteration.

Released: 25-May-2023 10:50 AM EDT
Gene editing tool could help reduce spread of antimicrobial resistance
University of Exeter

A new tool which could help reduce the spread of antimicrobial resistance is showing early promise, through exploiting a bacterial immune system as a gene editing tool.

Released: 25-May-2023 10:35 AM EDT
Colon cancer: Curcumin activates tumor suppressive signaling pathway
Ludwig Maximilians Universität München (Munich)

Colorectal cancer is one of the most common types of cancer worldwide. In over half of all cases, an important protective mechanism in cells is inactivated by mutations – the tumor suppressor gene p53.

Released: 25-May-2023 1:30 AM EDT
Genetic research offers new perspective on the early evolution of animals
University of Vienna

A study published by MBARI researchers and their collaborators today in Nature provides new insights about one of the earliest points in animal evolution that happened more than 700 million years ago.

22-May-2023 11:55 AM EDT
Cleft lip caused by combination of genes and environment
University College London

A cleft lip or palate arises from the combined effects of genes and inflammatory risk factors experienced during pregnancy, such as smoking or infections, finds a new study led by UCL researchers.

19-May-2023 4:10 PM EDT
Does Having Alzheimer’s Genes Increase Your Risk of Epilepsy?
American Academy of Neurology (AAN)

People with a genetic predisposition for Alzheimer’s disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise: Epigenetic landscape modulates pioneer transcription factor binding
Released: 24-May-2023 3:05 PM EDT
Epigenetic landscape modulates pioneer transcription factor binding
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA.

Newswise: SWI/SNF complexes “bookmark” cell identity during division
Released: 24-May-2023 11:15 AM EDT
SWI/SNF complexes “bookmark” cell identity during division
St. Jude Children's Research Hospital

Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.

19-May-2023 10:05 AM EDT
Study reveals unique molecular machinery of woman who can’t feel pain
University College London

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL.

   
Newswise: Engineers create bacteria that can synthesize an unnatural amino acid
Released: 23-May-2023 4:20 PM EDT
Engineers create bacteria that can synthesize an unnatural amino acid
University of Delaware

University of Delaware researchers in the lab of Aditya Kunjapur, assistant professor in the College of Engineering’s Department of Chemical and Biomolecular Engineering, have engineered bacteria to synthesize an amino acid that contains a rare functional group that others have shown to have implications in the regulation of our immune system. The researchers also taught a single bacterial strain to create the amino acid and place it at specific sites within target proteins.

Released: 23-May-2023 10:00 AM EDT
Hertz Foundation Announces 2023 Hertz Fellows
The Fannie and John Hertz Foundation

From advancing artificial intelligence to strengthening our national security, the 2023 Hertz Fellows will address the most pressing challenges facing our nation.

   
Newswise: Siblings with autism share more of dad’s genome, not mom’s
Released: 22-May-2023 8:40 PM EDT
Siblings with autism share more of dad’s genome, not mom’s
Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory (CSHL) researchers have flipped the script on autism spectrum disorder (ASD) genetics.

Newswise: New study sheds light on complex genetics of autism in East African families
Released: 22-May-2023 12:25 PM EDT
New study sheds light on complex genetics of autism in East African families
UT Southwestern Medical Center

UT Southwestern Medical Center researchers have identified hundreds of genomic variants associated with autism spectrum disorder (ASD) in East African families who have a markedly higher prevalence of the neurodevelopmental condition than other populations worldwide. The study, published in Cell Genomics, is the first to investigate the genetics of ASD in an African population, an important step toward decreasing racial and ethnic health disparities for this condition, the authors said.

Newswise: A New Map Reveals the Complicated World in Which Cells Seek to Repair Damaged DNA
Released: 22-May-2023 11:50 AM EDT
A New Map Reveals the Complicated World in Which Cells Seek to Repair Damaged DNA
University of California San Diego

UC San Diego scientists develop an interactive software that enables scientists to better investigate the DNA damage response.

Released: 22-May-2023 10:05 AM EDT
Effects on memory of neuron diversity in brain region revealed
Cornell University

Neurons in a key area of the brain have different functions based on their exact genetic identity, and understanding this diversity could lead to better understanding of the brain’s computational flexibility and memory capacity, potentially informing disease treatment options, Cornell researchers report in a new study.

Newswise: Puppeteer fungus’ targeted takeover of zombie flies
Released: 19-May-2023 6:05 PM EDT
Puppeteer fungus’ targeted takeover of zombie flies
Harvard University, Department of Organismic and Evolutionary Biology

In a new study published in eLife, lead author Carolyn Elya, postdoctoral researcher in the Department of Organismic and Evolutionary Biology at Harvard, reveals the molecular and cellular underpinnings behind the parasitic fungus, Entomophthora muscae’s (E. muscae), ability to manipulate the behavior of fruit flies.

Newswise: A ribosomal traffic jam that breaks the heart
Released: 19-May-2023 2:30 PM EDT
A ribosomal traffic jam that breaks the heart
Kyushu University

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

Newswise: Artificial Intelligence Catalyzes Gene Activation Research and Uncovers Rare DNA Sequences
Released: 19-May-2023 1:40 PM EDT
Artificial Intelligence Catalyzes Gene Activation Research and Uncovers Rare DNA Sequences
University of California San Diego

Biologists have used machine learning, a type of AI, to identify “synthetic extreme” DNA sequences with specifically designed functions in gene activation. They tested 50 million DNA sequences and found synthetic DNA sequences with activities that could be useful in biotechnology and medicine.

Newswise: Renowned Researcher Bradley R. Cairns, PHD, Elected as a Fellow of the Royal Society
Released: 18-May-2023 4:40 PM EDT
Renowned Researcher Bradley R. Cairns, PHD, Elected as a Fellow of the Royal Society
University of Utah Health

Cairns joins renowned scientists as part of the Royal Society, known for its significant role in many scientific discoveries. Cairns is the second current faculty member elected at the U.

Released: 18-May-2023 3:20 PM EDT
MSU researchers uncover the hidden complexity of the Montmorency tart cherry genome
Michigan State University

Since Michigan is the nation's leading producer of tart cherries, Michigan State University researchers were searching for the genes associated with tart cherry trees that bloom later in the season to meet the needs of a changing climate. They started by comparing DNA sequences from late-blooming tart cherry trees to the sequenced genome of a related species, the peach. However, in a surprise to the researcher, the genetic discrepancies between the species outweighed the similarities. This led the team to create the first annotated Montmorency tart cherry genome and identify the DNA segments that code for each gene.

Newswise: World-Renowned Paleoanthropologist Richard Leakey To Be Honored at Week-Long Conference at Stony Brook University
Released: 18-May-2023 2:30 PM EDT
World-Renowned Paleoanthropologist Richard Leakey To Be Honored at Week-Long Conference at Stony Brook University
Stony Brook University

Stony Brook University will honor the life and legacy of eminent paleoanthropologist, conservationist and politician Richard E. Leakey by hosting “Africa: The Human Cradle: An International Conference Paying Tribute to Richard E. Leakey” from June 5 - 9, 2023 at the university’s Charles B. Wang Center. The Turkana Basin Institute (TBI) and Stony Brook are hosting the conference, in partnership with the National Geographic Society. Thought leaders from around the world will celebrate the immeasurable, life-long contributions by Leakey to furthering the appreciation of Africa’s centrality in the narrative of human evolution.

Newswise: How cells select DNA damage repair pathways
Released: 18-May-2023 1:10 PM EDT
How cells select DNA damage repair pathways
Institute for Basic Science

DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic chemicals.

Released: 18-May-2023 11:05 AM EDT
Study reveals key molecular interaction that sets the timing of our biological clocks
University of California, Santa Cruz

Molecular clocks in our cells synchronize our bodies with the cycle of night and day, cue us for sleep and waking, and drive daily cycles in virtually every aspect of our physiology. Scientists studying the molecular mechanisms of our biological clocks have now identified a key event that controls the timing of the clock.

Released: 18-May-2023 11:05 AM EDT
AMP Offers Evidence-Based Recommendations for Next-Generation Sequencing Germline Variant Confirmation
Association for Molecular Pathology

The Association for Molecular Pathology (AMP) has published a report that was designed to establish recommendations for standardizing orthogonal confirmation practices for germline variants detected by next-generation sequencing (NGS) in The Journal of Molecular Diagnostics.

Newswise: Un Estudio Proporciona Información Acerca de la Causa de la Enfermedad Intestinal Inflamatoria Grave
Released: 18-May-2023 10:05 AM EDT
Un Estudio Proporciona Información Acerca de la Causa de la Enfermedad Intestinal Inflamatoria Grave
Cedars-Sinai

Investigadores de Cedars-Sinai han identificado una variante genética que aumenta el riesgo de las personas de desarrollar la enfermedad de Crohn perianal, la manifestación más debilitante de la enfermedad de Crohn.

Released: 18-May-2023 10:05 AM EDT
UCLA study shows accuracy of genetically based disease predictions varies from individual-to-individual
University of California, Los Angeles (UCLA), Health Sciences

Polygenic scores – estimates of an individual’s predisposition for complex traits and diseases – hold promise for identifying patients at risk of disease and guiding early, personalized treatments, but UCLA experts found the scores fail to account for the wide range of genetic diversity across individuals in all ancestries.

Released: 17-May-2023 8:00 PM EDT
Confirming the safety of genetically edited allergen-free eggs
Hiroshima University

Researchers have developed a chicken egg that may be safe for people with egg white allergies.

   
Released: 17-May-2023 7:00 PM EDT
Scales or feathers? It all comes down to a few genes
Université de Genève (University of Geneva)

Two researchers from the University of Geneva (UNIGE) have discovered how to permanently transform the scales that normally cover the feet of chickens into feathers, by specificially modifying the expression of certain genes.

Released: 17-May-2023 1:15 PM EDT
New Computational Tool Identifies Novel Targets for Cancer Immunotherapy
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets. The tool, called “Isoform peptides from RNA splicing for Immunotherapy target Screening” (IRIS), was described in a paper published today in the Proceedings of the National Academy of Sciences.

Newswise: How Breast Cancer Arises
15-May-2023 7:45 PM EDT
How Breast Cancer Arises
Harvard Medical School

At a glance: Researchers trace the origin of certain breast cancers to genomic reshuffling — rearrangement of chromosomes — that activates cancer genes and ignites disease. The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development. The study shows the sex hormone estrogen — thus far thought to be only a fuel for breast cancer growth — can directly cause tumor-driving genomic rearrangements.

Newswise: New neurodevelopmental disorder identified among patients with common symptoms
Released: 17-May-2023 10:05 AM EDT
New neurodevelopmental disorder identified among patients with common symptoms
UT Southwestern Medical Center

A new type of developmental disability caused by mutations in a gene known as CBX1 has been discovered by a UT Southwestern Medical Center researcher and his colleagues. The findings, reported in Genetics in Medicine, an official journal of the American College of Medical Genetics and Genomics (ACMG), offer insight into the role this gene plays in development and could eventually lead to therapies for a range of related disorders.

Newswise: Simulation tools drive the new generation of therapies based on gene silencing
Released: 17-May-2023 5:05 AM EDT
Simulation tools drive the new generation of therapies based on gene silencing
Institute for Research in Biomedicine Barcelona

Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA. By reading their DNA letters, cells produce an intermediate RNA molecule that will give rise to the corresponding protein. Most diseases occur with altered protein levels, which are either a cause or consequence of the condition itself. RNA plays a pivotal role in diseases with altered protein levels by serving as the intermediary messenger between DNA and protein.

   
Newswise: Study first to examine how early memory changes as we age at a cellular level
Released: 16-May-2023 8:00 PM EDT
Study first to examine how early memory changes as we age at a cellular level
The Hospital for Sick Children

How do our brains become capable of creating specific memories? In one of the first preclinical studies to examine memory development in youth, a research team at The Hospital for Sick Children (SickKids) may have identified a molecular cause for memory changes in early childhood.

Released: 16-May-2023 5:45 PM EDT
How superbug A. baumannii survives metal stress and resists antibiotics
Macquarie University

An international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator.

Newswise: Researchers track antimicrobial resistance in E. coli isolated from swine
Released: 16-May-2023 4:05 PM EDT
Researchers track antimicrobial resistance in E. coli isolated from swine
University of Illinois Urbana-Champaign

The spread of drug-resistant microbes has become a global health concern that threatens our ability to treat infections. The widespread use of antimicrobials in livestock, such as swine farms, exacerbates this problem.

   
Released: 16-May-2023 2:00 PM EDT
May is Melanoma and Skin Cancer Awareness Month. Keep up with the latest news on skin in the Dermatology channel
Newswise

Skin cancer is the most prevalent form of cancer in the United States, with over 5 million cases diagnosed annually. The Centers for Disease Control and Prevention reports that melanoma alone accounts for more than 8,000 deaths each year. Thankfully, skin cancer is highly preventable, making it crucial to prioritize protection. Below are some of the latest headlines in the Dermatology channel.

Newswise: Timing is everything: New insights into floral development unveil nature's perfect clock
Released: 16-May-2023 12:10 PM EDT
Timing is everything: New insights into floral development unveil nature's perfect clock
Nara Institute of Science and Technology

The intricate process of flower development has long fascinated scientists seeking to unravel the mysteries behind nature's precision timing.

Released: 16-May-2023 9:30 AM EDT
Penn Medicine at the American Society of Gene and Cell Therapy 26th Annual Meeting
Perelman School of Medicine at the University of Pennsylvania

Researchers from the Gene Therapy Program (GTP) at the Perelman School of Medicine at the University of Pennsylvania will present nine abstracts highlighting their translational science and discovery research on gene therapy, gene editing, and adeno-associated virus (AAV) vector technology at the American Society of Cell and Gene Therapy (ASGCT) 26th Annual Meeting on May 16–20, 2023 in Los Angeles, California.

Newswise: Newly discovered RNA molecules hold promise for detecting and treating esophageal cancer
Released: 15-May-2023 4:45 PM EDT
Newly discovered RNA molecules hold promise for detecting and treating esophageal cancer
Case Western Reserve University

Irregularities in the body’s genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn’t clear. Could abnormalities in non-coding material also impact a person’s health, or even be linked to cancers as well? A new study by researchers at the Case Western Reserve University School of Medicine suggests that the non-coding genetic molecules also play a key role in health and disease, including tumor development.

Released: 15-May-2023 11:05 AM EDT
New study finds the placenta, not only the brain, plays a central role in genetic risk of schizophrenia
Lieber Institute for Brain Development, Maltz Research Laboratories

More than 100 genes linked to the risk of schizophrenia seem to cause illness because of their role in the placenta rather than in the developing brain, according to a new study led by the Lieber Institute for Brain Development.

Newswise: WFIRM bioprinting research makes history when it soars to the ISS
Released: 15-May-2023 8:00 AM EDT
WFIRM bioprinting research makes history when it soars to the ISS
Atrium Health Wake Forest Baptist

The Wake Forest Institute for Regenerative Medicine (WFIRM) will make history this month when the first bioprinted solid tissue constructs soar to the International Space Station (ISS) on board the next all private astronaut mission by commercial space leader Axiom Space.

   
Newswise: New algorithm can predict diabetic kidney disease
Released: 15-May-2023 5:00 AM EDT
New algorithm can predict diabetic kidney disease
Sanford Burnham Prebys

Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. The findings could help doctors prevent or better manage kidney disease in people with type 2 diabetes.

Released: 12-May-2023 5:20 PM EDT
Researchers discover a way to improve nonviral gene editing as well as a new type of DNA repair
University of California, Santa Barbara

Gene editing is a powerful method for both research and therapy. Since the advent of the Nobel Prize-winning CRISPR/Cas9 technology, a quick and accurate tool for genome editing discovered in 2012, scientists have been working to explore its capabilities and boost its performance.

   
Released: 11-May-2023 6:00 PM EDT
Like ancient mariners, ancestors of Prochlorococcus microbes rode out to sea on exoskeleton particles
Massachusetts Institute of Technology (MIT)

In a new study they propose that ancestors of Prochlorococcus acquired an ability to latch onto chitin — the degraded particles of ancient exoskeletons. The microbes hitched a ride on passing flakes, using the particles as rafts to venture further out to sea. These chitin rafts may have also provided essential nutrients, fueling and sustaining the microbes along their journey.

Newswise: Study Reveals How Fatty Liver Promotes Colorectal Cancer Spread
Released: 11-May-2023 5:40 PM EDT
Study Reveals How Fatty Liver Promotes Colorectal Cancer Spread
Cedars-Sinai

Investigators at Cedars-Sinai Cancer found that fatty liver, a condition closely associated with obesity, promotes the spread of colorectal cancer to the liver. Their study, published today in the peer-reviewed journal Cell Metabolism, details the process at the cellular level and could change the way doctors manage the disease in some patients.

Newswise: SARS-CoV-2 seasonal behavior traced back to genetics and global change
Released: 11-May-2023 4:30 PM EDT
SARS-CoV-2 seasonal behavior traced back to genetics and global change
College of Agricultural, Consumer and Environmental Sciences, University of Illinois Urbana-Champaign

As the northern hemisphere heads into summer, we may be in for a COVID-19 reprieve. Not because the pandemic is over; the Omicron subvariant ‘Arcturus’ is still creeping upward and causing new symptoms. But two new studies from the University of Illinois add evidence supporting a seasonal pattern in the behavior of the SARS-CoV-2 virus.

Newswise: Targeting uncontrolled inflammation may hold the key to treating therapy-resistant cancers
Released: 11-May-2023 1:15 PM EDT
Targeting uncontrolled inflammation may hold the key to treating therapy-resistant cancers
Van Andel Institute

Van Andel Institute scientists have pinpointed how a specific gene mutation triggers an inflammatory cascade that may drive development of treatment-resistant cancers.



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