A systematic study of seven antioxidants commonly taken by or suggested to benefit children and adults affected with mitochondrial disease provides intriguing clues that at least two compounds should be further evaluated in clinical trials. There are currently no proven, effective treatments for mitochondrial disease.
Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type of high blood pressure in lungs that ultimately leads to right heart failure and death.
Microbiologist Emily Cope talks about her research on how altered microbiota composition or function influences airway inflammatory diseases, chiefly CRS as well as asthma and cystic fibrosis.
Cancer experts debate whether there's a glut of immunotherapy trials.
Cultural taboos surrounding the disease have lessened, but continued research and education are still needed.
The drug, regadenoson, is already commonly used to image cardiac patients’ hearts. But the UVA research suggests it could be put to another, lifesaving purpose.
As the winter cold season melts into seasonal spring allergies, many people may start to experience sneezing, wheezing and other breathing difficulties. Sometimes, the trouble goes away after a few days, but if it lingers or recurs, asthma could be the culprit.
Understanding of tuberculosis is associated with higher, not lower, stigmatization of TB patients in Brazil, according to a new “Insights” report from Vanderbilt’s Latin American Public Opinion Project.
Limiting first-year medical residents to 16-hour work shifts, compared to “flexing” them to allow for some longer shifts, generally makes residents more satisfied with their training and work-life balance, but their training directors more dissatisfied with curtailed educational opportunities. That’s one conclusion of a new study published online March 20 in the New England Journal of Medicine.
Every year, approximately 12 million adults in the U.S. are diagnosed with Chronic Obstructive Pulmonary Disease, and 120,000 die from it. For people with COPD, Haemophilus influenzae, a bacterium, can be particularly dangerous. Now, researchers have unraveled how the bacterium adapts quickly, which may open new avenues for therapy for COPD and other diseases such as ear infections or pneumonia.
Children with mild to moderate asthma do not benefit from a common practice of increasing their inhaled steroids at the first signs of an asthma exacerbation, according to clinical trial results published in The New England Journal of Medicine. Researchers found short-term increases in inhaled steroids did not prevent attacks in children aged 5 to 11, and may even slow a child’s growth.
Imagine if doctors could diagnose their patients with lung or esophageal cancer by simply swabbing the inside of their cheeks. Vadim Backman, a biomedical engineer at Northwestern University, has developed a new technology that could make that seemingly simple solution a reality.
Scientists are one step closer to understanding how cells reshape their surfaces to internalize material from their surroundings, thanks to collaboration among researchers from two South Dakota universities and the National Institutes of Health.
Nearly all school nurses participating in a national survey (96 percent) reported that staff at their school received training on handling severe allergic reactions to food. Over 80 percent asserted that their school had an emergency epinephrine auto-injector on hand to stop a potentially life-threatening allergic reaction. The study findings, published in the Annals of Allergy, Asthma and Immunology, also underscore the dire need for these policies, with over one-third of the school nurses reporting at least one severe allergic reaction to food at their school in the last academic year.
Mayo Clinic和IBM Watson Health今天公布了早期使用沃森（Watson）系统 （IBM的一个认知计算系统）进行临床试验匹配的结果。在Mayo Clinic的肿瘤医疗服务中使用该系统与参加Mayo乳腺癌临床试验的患者增加有关联。
“Did you smoke?” Few questions engender such anger and annoyance in patients as that one, particularly in the 10%-20% of lung cancer patients who are “never smokers.” Read “Never Smokers: The New Face of Lung Cancer”—the latest blog from Dr. Brendon M. Stiles of Weill Cornell Medicine, New York-Presbyterian Hospital.
New research suggests that certain areas of the lungs are more likely than others to show age-related damage that compromises respiratory function. The paper is published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology.
CSU Bakersfield microbiology professor Antje Lauer says the state is tracking toward an epidemic of the infectious lung disease.
Researchers have found strong evidence that environmental exposures, including air pollution, affect gene expressions associated with respiratory diseases much more than genetic ancestry. The study, published today in Nature Communications, analyzed more than 1.6 million data points from biological specimens, health questionnaires and environmental datasets, making this study one of the largest ever to examine the relationship between gene expression and environmental stimuli. These findings represent a groundbreaking use of big data to uncover the environmental factors that are behind diseases and inform strategies for prevention, an approach that would apply to a number of diseases, including cancer.
Anthelmintic drug already approved to treat infections of pinworm parasite was shown to effectively impair both mesothelioma cell growth and migration.
Increasing the body’s ability to produce lipids in the lungs after damage prevents the progression of pulmonary fibrosis in preliminary studies.
Neurons that carry nerve signals to and from the lungs suppress immune response during fatal lung infections with the bacterium Staphylococcus aureus. Animal experiments show that disabling these neurons can boost immune response and promote bacterial clearance to aid recovery. Targeting neuro-immune signaling in the lungs can pave the way to nonantibiotic therapies for bacterial pneumonia.
A low dose of the sedative dexmedetomidine given at night may prevent delirium in critically ill patients, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
Researchers have identified a lung stem cell that repairs the organ’s gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated they are essential to repairing lung tissue damaged by severe influenza and other respiratory ailments.
Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate. Scientists describe cells that could become a new tool to treat lung diseases across the lifespan, from premature infants to the elderly.
Critically ill patients who experience long periods of hypoxic, septic or sedative-associated delirium, or a combination of the three, during an intensive care unit (ICU) stay are more likely to have long-term cognitive impairment one year after discharge from the hospital, according to a new study.
The passage of critical mine health and safety legislation in the late 1960s, along with advances in technology and safety practices, helped to decrease the prevalence of lung diseases for miners. But starting in the mid-1990s, there was a significant documented increase in lung diseases among coal workers, especially among younger workers.
Women who work as cleaners or regularly use cleaning sprays or other cleaning products at home appear to experience a greater decline in lung function over time than women who do not clean, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
Women with asthma who only use short-acting asthma relievers take longer to become pregnant than other women, according to international research led by the University of Adelaide.
New guidelines developed collaboratively by the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network® (NCCN®) offer clinicians much needed recommendations for assessment and management of side effects related to immune checkpoint inhibitors.
5 tips from the American College of Allergy, Asthma and Immunology for parents who’d like to send their child with allergies or asthma to summer camp, and still keep them safe.
LJI researchers report mechanisms used by a subgroup of ILCs, known as ILC2 cells, to undergo maturation required for them to mount an effective immune response. These discoveries suggest a novel approach to treat inflammatory disease caused by overactive ILC2s.
Opioid users have a significantly increased risk of infections severe enough to require treatment at the hospital, such as pneumonia and meningitis, as compared to people who don’t use opioids.
Based on a detailed statistical analysis of multiple datasets, the Flint Area Community Health and Environment Partnership (FACHEP) research team found that the majority of Legionnaires’ disease cases that occurred during the 2014-15 outbreak in Genesee County, Michigan
Clinical application of cancer fighting nanovaccines has been hampered by complications in large-scale manufacturing, quality control, and safety. Biomedical engineers developed nanovaccines that bind to the albumin protein naturally present in the body. The albumin protein then delivers these nanocomplexes to the lymph nodes, resulting in potent immune activation against multiple tumor types in mouse cancer models. The use of natural albumin as a universal vaccine shuttle is a significant step towards the application of cancer nanovaccine immunotherapy in humans.
Doctors ask patients about smoking habits for the same reason they check weight, blood pressure, breathing and heart beat during a visit.
Houston Methodist researchers have a new explanation for what causes the lungs’ airways to close during asthma attacks. The researchers who published the study in the Feb. 5 issue of the Journal of Experimental Medicine note that the discovery holds promise for developing a new class of drugs different from the steroids currently used to treat asthma.
A study of 30,000 children with earaches, strep throat and other common infections found that narrow-spectrum antibiotics had fewer adverse effects than broad-spectrum antibiotics. A more selective approach is better, said researchers.
Experts from three major organizations add ROS1 to list of tests matching lung cancer with targeted treatments.
A phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity is described in the SLAS Discovery February 2018 front cover feature article by Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA).
The Transplant Institute at NYU Langone Health launches new lung transplant program.
Intermountain Healthcare has endorsed the The National Comprehensive Cancer Network® (NCCN®) Imaging Appropriate Use Criteria (NCCN Imaging AUC™). Intermountain will aggregate the NCCN AUC for lung cancer with its own AUC and utilize the content for decision support.
Progress in treating lung cancer has been enormous in the past 20 years according to a new review by researchers at Yale Cancer Center.
People with the rare genetic disease primary ciliary dyskinesia suffer repeated lung infections because they lack functional cilia, hairlike structures that sweep mucus through the airways. Most people have errors in the molecular motor that powers the cilia. But some have errors in non-motor proteins. Now, Washington University School of Medicine in St. Louis researchers report that mutated non-motor proteins cause disease by assembling the motor incorrectly. The findings suggest new routes to drug discovery.
CF researchers have now shown that the lungs’ bacterial population changes in the first few years of life as respiratory infections and inflammation set in. This research offers a way to predict the onset of lung disease and suggests a larger role for preventive therapies, such as hypertonic saline.
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