The Wistar Institute's Dr. Alessandro Gardini and his lab have published their new paper, “The enhancer module of integrator controls cell identity and early neural fate commitment,” in the journal Nature Cell Biology.
A new gene-editing pipeline cuts the time to generate a transgenic mouse line by a month by providing cheaper, better, faster CRISPR.
Genetic researchers at the UNC School of Medicine have identified a key focal point in the biological processes that control cell identity and can lead to disease when mutated.
A simple biomaterial-based strategy that can influence the behavior of cells could pave the way for more effective medical treatments such as wound healing, cancer therapy and even organ regeneration, according to a research team at Penn State.
A new study shows that photoreceptor cells in the retina exhibit planar polarity, i.e. their light-sensitive cilia orient themselves in a coordinated manner.
Researchers at Children’s Hospital of Philadelphia (CHOP) announced the creation of a new AI technology called CelloType, a comprehensive model designed to more accurately identify and classify cells in high-content tissue images.
Researchers from the University of Chicago recently developed a new approach for identifying new cellular RNA targets of snoRNAs. They uncovered thousands of previously unknown targets for snoRNAs in human cells and mouse brain tissues, including many that serve functions other than guiding rRNA modifications.
Georgios Skiniotis, PhD, to develop and lead new center focusing on advanced imaging techniques, including cryo-ET.
Researchers at WashU Medicine shrink gastrointestinal tumors in mice using a yeast probiotic to deliver immunotherapy to the gut, offering a potentially novel strategy to target hard-to-reach gut cancers.
Up until recently, habituation — a simple form of learning — was deemed the exclusive domain of complex organisms with brains and nervous systems, such as worms, insects, birds, and mammals. But a new study, published Nov. 19 in Current Biology, offers compelling evidence that even tiny single-cell creatures such as ciliates and amoebae, as well as the cells in our own bodies, could exhibit habituation akin to that seen in more complex organisms with brains.
Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood. Molecular biologists Alexander Stockinger, Leonie Adelmann and Florian Raible from the Max Perutz Labs at the University of Vienna have now made an important contribution to clarifying this question in a new study.
Researchers have identified new roles for a protein long known to protect against severe flu infection – among them, raising the minimum number of viral particles needed to cause sickness.
Hematology researchers from Sylvester Comprehensive Cancer Center and the Miller School of Medicine at the University of Miami are authors or co-authors on more than 70 posters to be presented at the Annual Meeting & Exposition of the American Society of Hematology in San Diego, Dec. 7-10. Links to each abstract are included in this tip sheet.
Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist? How did these early protocells develop the structural membranes necessary for cells to thrive and assemble into complex organisms? New research from UC San Diego has uncovered a plausible explanation involving the reaction between two simple molecules.
A pivotal study has uncovered a genetic defense mechanism in lily plants against Botrytis cinerea, the fungus behind gray mold disease. Central to this defense is LlHSFA4, a transcription factor that, when activated, initiates a robust response against the pathogen. This discovery could transform strategies for protecting horticultural crops from severe fungal infections.
A recent study in Ficus hispida genomics has unlocked the genetic mechanisms driving this fig tree’s unique reproductive system. The fully sequenced genome, a first of its kind for Ficus, reveals critical insights into how sex is determined in these plants—a factor crucial to their survival and ecological role. This research is a milestone for advancing the understanding of dioecy in plants and could open new doors for plant breeding and ecosystem management.
At a glance: A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full story behind how cancer arises. Study identifies cellular changes that prime cancer-related genes for action and render cells vulnerable to tumor growth. The findings can inform new treatments that block the priming effect to prevent breast cancer formation.
Scientists at St. Jude Children’s Research Hospital have uncovered a previously unrecognized tumor suppression mechanism through the study of condensates and ribosome formation.
Pioneering research has unlocked new understanding of the genetic intricacies within the octoploid strawberry, focusing on the interplay and divergence among its four ancestral subgenomes. This work provides critical insights into the genetic foundations that govern key agronomic traits such as flavor, fruit quality, and disease resistance, essential for shaping the future of strawberry breeding programs.
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