Heart failure patients with preserved ejection fraction (HFpEF) — where the heart becomes stiff and cannot relax or fill properly — did not have increased exercise tolerance after taking isosorbide mononitrate, compared to a placebo.
For patients undergoing plastic surgery procedures, there's no consistent evidence that taking antidepressants increases the risk of bleeding, breast cancer, or other adverse outcomes, concludes a research review in the November issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Proton pump inhibitors (PPIs), a class of drugs used to treat acid reflux and other acid-related gastrointestinal conditions, may increase the risk for developing chronic kidney disease (CKD). Two new studies that reached similar conclusions on the increased CKD risk associated with PPI use will be presented at ASN Kidney Week 2015 November 3–8 at the San Diego Convention Center in San Diego, CA.
A new study from the University of Michigan Comprehensive Cancer Center reveals molecular changes within a tumor that are preventing immunotherapy drugs from killing off the cancer.
Researchers discover way to bypass faculty cell signaling that leads to muscle damage in Duchene muscular dystrophy.
Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences have found that the breast cancer drug tamoxifen gives white blood cells a boost, better enabling them to respond to, ensnare and kill bacteria in laboratory experiments. Tamoxifen treatment in mice also enhances clearance of the antibiotic-resistant bacterial pathogen MRSA and reduces mortality.
An experimental, biologic treatment, brodalumab, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment, according to the results of a multicenter clinical trial led by Mount Sinai researchers and published online today in the New England Journal of Medicine.
When it comes to treating depression, how well a person responds to a fake medicine may determine how well they’ll respond to a real one, a new study shows. Those who can muster their brain’s own chemical forces against depression have a head start in overcoming symptoms with help from medication.
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) describe a class of compounds with the potential to stop chronic itch without the adverse side effects normally associated with medicating the condition.
researchers from the University of Zurich, Switzerland have made a breakthrough by obtaining the first nanometer (one billionth of a meter) resolved image of individual tobacco mosaic virions, a rod-shaped RNA virus that infects a wide range of plants, especially tobacco. The work demonstrates the potential of low-energy electron holography as a non-destructive, single-particle imaging technique for structural biology. The researchers describe their work in a paper published this week on the cover of the journal Applied Physics Letters, from AIP Publishing.
More than half of older adults with clinical depression don’t get better when treated with an antidepressant. But results from a multicenter clinical trial that included Washington University School of Medicine in St. Louis indicates that adding a second drug — an antipsychotic medication — to the treatment regimen helps many of those patients.
In an international Phase III randomized study, everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), has shown to dramatically improve progression-free survival for patients with advanced, nonfunctional neuroendocrine tumors (NET) of the lung and gastrointestinal tract.
For the first time, an immune checkpoint inhibitor has been proven to increase survival among patients with advanced renal cell carcinoma (RCC), a patient population for whom treatment options are currently limited.
A new study has shown that for certain cancer drugs, participants in clinical trials are often not representative of the patients that ultimately take the drugs, raising questions about the direct applicability of trial data.
A University of Adelaide led study has found that a psychiatric drug claimed to be a safe and effective treatment for depression in adolescents is actually ineffective and associated with serious side effects.
A novel, one-step method to treat ulcerative colitis with an oral drug consisting of microparticles and natural herbal molecules that target the colon shows promise as an effective therapy, according to researchers from the Institute for Biomedical Sciences at Georgia State University and Southwest University in China.
Drugs commonly used to treat high blood pressure, and prevent heart attacks and strokes, are associated with significantly worse cardiovascular outcomes in hypertensive African Americans compared to whites, according to a new comparative effectiveness research study led by researchers in the Department of Population Health at NYU Langone Medical Center, published in the Journal of the American College of Cardiology.
Researchers at the National University of Singapore (NUS) have developed a technique to observe, in real time, how individual blood components interact and modify advanced nanoparticle therapeutics.
A scientist at the University of Virginia School of Medicine is rescuing vast amounts of humanity’s knowledge of the submicroscopic world from potential oblivion, making it more accessible than ever before and doing so on a budget many thought impossible.
Many of us are guilty of neglecting our medicine cabinet – specifically, our prescriptions. Sometimes we feel the need to hang onto them, perhaps because they were costly or "just in case." But doing so may cause more harm than good.
Researchers from the Icahn School of Medicine at Mount Sinai and Princeton University have designed a new online tool that predicts the role of key proteins and genes in diseases of the human immune system.
Agent shows efficacy in inhibiting inflammation and preventing or delaying uterine contractions and premature delivery in murine models – without adversely affecting the fetus or the mother. This discovery is a giant step towards preventing prematurity, the world's leading cause of infant death.
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A multinational team of physicians and scientists from City of Hope, the San Francisco Bay area and Europe recently reported success of a phase II clinical trial of a novel drug against essential thrombocythemia (ET), one of three myeloproliferative neoplasms (MPNs).
Scientists at Queen’s University Belfast are developing a potential revolutionary new treatment for Sepsis and Acute Respiratory Distress Syndrome (ARDS), which are among the leading causes of death in hospitalised patients in the UK.
Scientists have discovered that wild blueberry extract could help prevent dental plaque formation.
Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.
Scientists from The Scripps Research Institute Florida campus have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output, findings that could aid future drug design.
Commonly used antidepressant drugs change levels of a key signaling protein in the brain region that processes both pain and mood, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published August 24 in the Proceedings of the National Academy of Sciences (PNAS).
A recently-published study found that while internal bleeding may be uncommon as a result of taking blood thinners such as Xarelto® (rivaroxaban) and Eliquis® (apixaban), the normal coagulation tests physicians use to check for the side effect of bleeding may not be reliable.
In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.
Among patients with active cancer and acute symptomatic venous thromboembolism (VTE; blood clots in the deep veins), the use of the low molecular-weight heparin tinzaparin daily for 6 months compared with warfarin did not significantly reduce recurrent VTE and was not associated with reductions in overall death or major bleeding, but was associated with a lower rate of clinically relevant nonmajor bleeding, according to a study in the August 18 issue of JAMA.
Two Florida laws, enacted to combat prescription drug abuse and misuse in that state, led to a small but significant decrease in the amount of opioids prescribed the first year the laws were in place, a new study by Johns Hopkins Bloomberg School of Public Health researchers suggests.
Antimicrobials, antidepressants, anticancer medicines have their roots in soils.
In an article published in JAMA Oncology, a study led by a UNC Lineberger Comprehensive Cancer Center researcher and colleagues shows that a system they developed accurately and reliably captures the patient experience with cancer drug side effects.
Alcoholism inflicts a heavy physical, emotional and financial toll on individuals and society. Now new discoveries and promising animal studies are offering a glimmer of hope that a new class of drugs could treat the disease without many of the unwanted side effects caused by current therapies. The scientists are presenting their work today at the 250th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
The start of the school year means new classes, new friends, homework and sports. It also brings the threat of head lice. Scientists report today that lice populations in at least 25 states have developed resistance to over-the-counter treatments still widely recommended by doctors and schools. The researchers are presenting their work today at the 250th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
To lose weight, boost energy or soothe nerves, many consumers turn to dietary supplements. But some of these products contain undeclared substances. To protect consumers from taking something without their knowledge, scientists have developed a technique to determine what secret ingredients could be lurking in these supplements. They report their approach, which helped them find the active Viagra ingredient and other synthetic designer compounds in various products, in ACS' Journal of Agricultural & Food Chemistry.
Medications commonly used to treat dementia could result in harmful weight loss, according to UCSF researchers, and clinicians need to account for this risk when prescribing these drugs to older adults, they said.
The U.S. Patent and Trademark Office has issued a patent to the University of Arkansas for a drug developed through research at the university for treatment of hair loss and other disorders.
Patients with hypertension benefit from interacting with a medical team that includes a pharmacist. Two studies showed pharmacist-included care teams delivered more hands-on and tailored medication regimens to patients, which yielded more effective blood-pressure control results than for those patients who did not have a pharmacist on hand.
Researchers at the University of California, San Diego School of Medicine have demonstrated a direct connection between two signaling proteins and liver fibrosis, a scarring process underlying chronic liver disease, the 12th leading cause of death in the United States.
In an analysis of expenditures for outpatient pharmacy products used by publicly insured children with serious chronic illness in California, treating hemophilia accounted for about 40 percent of expenditures but included just 0.4 percent of the group studied, suggesting a need to improve pricing for this and other effective yet high-cost medications, according to a study in the July 28 issue of JAMA.
Moffitt Cancer Center researchers have published a study in the Journal of the National Cancer Institute that analyzed the participation rate of patients in pharmacogenomic trials.
Researchers at MIT’s Koch Institute for Integrative Cancer Research and Massachusetts General Hospital have created a polymer gel that could allow for the development of long-acting devices that reside in the stomach, including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a study by researchers at UC San Francisco.
Other topics include ethnic disparities in pain treatment, colon cancer and IBD, halting Liver cancer, and more...
Researchers at Columbia University Medical Center (CUMC) have developed a computer algorithm that is helping scientists see how drugs produce pharmacological effects inside the body. The study, published in the journal Cell, could help researchers create drugs that are more efficient and less prone to side effects, suggest ways to regulate a drug's activity, and identify novel therapeutic uses for new and existing compounds.
Physicians in training are twice as likely to order a costly brand-name statin (used to lower blood cholesterol levels) when supervised by senior physicians who prefer those medications in their own practice, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania and published online in the Journal of General Internal Medicine.
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