Rejuvenating the immune cells that live in tissues surrounding the brain improves fluid flow and waste clearance from the brain — and may help treat or even prevent neurodegenerative diseases such as Alzheimer’s and Parkinson’s, according to a study by researchers at Washington University School of Medicine in St. Louis.
While police officers are often dispatched alongside other first responders when drug overdoses are reported, an analysis of hundreds of overdose events in one Rhode Island city found that there were scant incidents that actually needed involvement from law enforcement.
A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free
New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, found that the biologic B-cell inhibitor belimumab was associated with a lower risk of severe infections and hospitalizations compared to nonbiologic immunosuppressants.
Researchers show how major sociopolitical events can have global impacts on sleep that are associated with significant fluctuations in the public’s collective mood, well-being, and alcohol consumption.
Consumers would be willing to buy milk from cows only treated with antibiotics when medically necessary – as long as the price isn’t much higher than conventional milk, according to researchers at Cornell University.
The Perot family, The Perot Foundation, and The Sarah and Ross Perot, Jr. Foundation have provided a transformative $50 million endowment for UT Southwestern’s Medical Scientist Training Program (MSTP), among the nation’s elite programs that provide graduates a dual M.D./Ph.D. degree to strengthen the advancement of laboratory discoveries into the clinical arena. Funding will provide a permanent endowment for the Perot Family Scholars Medical Scientist Training Program – one of just 54 M.D./Ph.D. training programs in the country supported by the National Institutes of Health (NIH).
Trauma can cause dissociative symptoms—such as having an out-of-body experience, or feeling emotionally numb—that may help an individual cope in the short term but can have negative impacts if the symptoms persist for a long period of time.
Scientists in the U.S. and UK illuminated the molecular events underlying an inherited movement and neurodegenerative disorder known as ARSACS – Autosomal recessive spastic ataxia of Charlevoix-Saguenay, named for two Quebec valleys where the first cases were found.
Using human brain organoids, an international team of researchers has shown how the SARS-CoV-2 virus that causes COVID-19 infects cortical neurons and specifically destroys their synapses — the connections between brain cells that allow them to communicate with each other.
A targeted therapy for children with high-risk Hodgkin lymphoma significantly reduced relapse rates, a large multicenter clinical trial conducted by the Children’s Oncology Group shows. The study results have been reported in the New England Journal of Medicine.
The Flow Cytometry Core at Sanford Burnham Prebys is getting a new piece of state-of-the-art research equipment, thanks to a grant from the National Institutes of Health.
A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center and the University of California San Francisco (UCSF) has discovered the underlying cause of gender differences in immunotherapy-associated myocarditis after immune checkpoint inhibitor (ICI) treatment. Their findings point to possible treatment strategies for this side effect, which disproportionately affects female patients.
In the past several years, myocarditis has been of public interest because of cases associated with vaccines for SARS-CoV2 or related conditions. Another form of myocarditis has been linked to immune checkpoint inhibitors (ICIs) used in cancer care. ICI-induced myocarditis is a potentially fatal side effect of ICI usage, and it appears that the adverse cardiac effects may disproportionally impact female patients. This finding is in contrast to other forms of myocarditis, with more cases reported in male patients.
Lowering the amount of nicotine in cigarettes to non-addictive levels may reduce smoking without worsening mental health in smokers with mood or anxiety disorders, according to College of Medicine researchers.
Growing up in a socioeconomically disadvantaged household may have lasting effects on children’s brain development, a large new study suggests. Compared with children from more-advantaged homes and neighborhoods, children from families with fewer resources have different patterns of connections between their brain’s many regions and networks by the time they’re in upper grades of elementary school. One socioeconomic factor stood out in the study as more important to brain development than others: the number of years of education a child’s parents have.
Donna Wilcock, Ph.D., of the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) was awarded a $1.7 million National Institutes of Health grant for her lab’s exploration of adverse effects of two new Alzheimer’s disease drugs — aducanumab and lecanemab — which have been shown to slow the progression of cognitive decline.
Using DNA from two ancient humans unearthed in two different archaeological sites in northeast Brazil, researchers have unraveled the deep demographic history of South America at the regional level with some surprising results. Not only do they provide new genetic evidence supporting existing archaeological data of the north-to-south migration toward South America, they also have discovered migrations in the opposite direction along the Atlantic coast – for the first time. Among the key findings, they also have discovered evidence of Neanderthal ancestry within the genomes of ancient individuals from South America. Neanderthals ranged across Eurasia during the Lower and Middle Paleolithic. The Americas were the last continent to be inhabited by humans.
Adults with hypertension saw a small, but consequential, rise in their blood pressure levels during the first eight months of the COVID-19 pandemic, while the number of times they had their blood pressure measured dropped significantly, according to a study supported by the National Institutes of Health.
Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.
UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.
Scientists report a method for stable attachment of peptides to tRNAs, which has allowed them to gain new fundamental insights into ribosome function by determining the atomic-level structures of ribosomes and the shapes that peptides take inside the ribosome.
One dose of an antibody drug safely protected healthy, non-pregnant adults from malaria infection during an intense six-month malaria season in Mali, Africa, a National Institutes of Health clinical trial has found.
Hypertension control and management worsened during the early months of the COVID-19 pandemic, according to a new analysis conducted at three large health systems, led by Cedars-Sinai investigators.
Measuring levels of a specific brain wave could lead to more objective, definitive methods of diagnosing concussions and determining when young athletes can safely return to play, according to a UT Southwestern stud
Engaging infants with a song provides a readymade means for supporting social development and interaction, according to a study published by the Proceedings of the National Academy of Sciences.
Researchers at UC San Diego report that a polygenic hazard score based on 290 genetic variants could be an effective tool for predicting genetic risk of lethal prostate cancer, which kills more than 34,000 men in the U.S. annually.
A faulty gene, rather than a faulty diet, may explain why some people gain excessive weight even when they don’t eat more than others, UT Southwestern researchers at the Center for the Genetics of Host Defense have discovered.
A new study from Washington University School of Medicine in St. Louis indicates that as patients age, Huntington's disease gradually impairs autophagy, which eliminates waste from cells. This housekeeping is significant because a buildup of waste in a specific kind of neuron leads to such cells’ untimely deaths. The researchers also showed that enhancing the autophagy pathway in such neurons that were created from skin cells of Huntington’s patients protects those cells from dying.
A new study sheds light on the basic biology of frontotemporal dementia caused by a particular genetic mutation
A Ludwig Cancer Research study has developed a novel nanotechnology that triggers potent therapeutic anti-tumor immune responses and demonstrated its efficacy in mouse models of multiple cancers.
Cleveland Clinic’s Lerner Research Institute was awarded a five-year $12 million grant by the National Cancer Institute, part of the National Institutes of Health, to define how cytokines - proteins produced during immune response - regulate inflammation and interact with cells and molecules surrounding tumors.
A panel of investigational monoclonal antibodies (mAbs) targeting different sites of the Epstein-Barr virus (EBV) blocked infection when tested in human cells in a laboratory setting.
Texas Biomed will help map the developing brain with unprecedented detail for the National Institutes of Health’s BRAIN Initiative Cell Atlas Network (BICAN). NIH recently awarded a total of $500 million to 11 teams that will work together to build a 3D brain atlas at single cell resolution over the next five years.
Researchers from The RNA Institute at the University at Albany have been awarded $1.4 million to investigate stress-induced RNA modifications and associated cell response. The focus of the study — “wobble uridines” in tRNA — could hold important clues for treating bacterial infections and detecting cancer.
A new grant from the National Institutes of Health to the Friedman School of Nutrition Science and Policy at Tufts University will fund the collaborative development of community-based programs to increase local production and consumption of fruits and vegetables in the Mississippi Delta.
A University of Kentucky Markey Cancer Center researcher’s team developed new chemical compounds that show promise as a potential anticancer therapy to treat aggressive tumors. The study led by Samuel G. Awuah, Ph.D., was published in Chemical Communications with Adedamola Arojojoye, a graduate student in Awuah’s lab as the paper’s first author.
Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.
Johns Hopkins Medicine researchers say they have successfully used a cell’s natural process for making proteins to “slide” genetic instructions into a cell and produce critical proteins missing from those cells.
La Jolla Institute for Immunology (LJI) researchers have made a major breakthrough in understanding how deletion of the genes that encode TET proteins can lead to cancer growth.
Using a new stem-cell based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).
Using a new stem-cell based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).
New research will aim to identify the electrical activity occurring as the brain receives information and then test whether targeted, gentle electrical stimulation can strengthen a specific memory.
New research from Yale Cancer Center reveals for the first time ever a differential clinical response to pembrolizumab in Lynch-like (mutated) vs methylated microsatellite instability-high (MSI-H) uterine cancer patients, increasing our understanding about the proportion of patients that derive benefit from immune checkpoint blockade.
University of Minnesota Twin Cities researchers are leading a comprehensive global clinical study that seeks to reveal the functional effects of vagus nerve stimulation (VNS) across the human body.
Two new studies from Washington University School of Medicine in St. Louis support development of a broadly applicable treatment for neurodegenerative diseases that targets a molecule that serves as the central executioner in the death of axons, the wiring of the nervous system.
The LJI team plans to use their new map of the Lassa virus surface glycoprotein to design a much-needed vaccine.
Scientists have discovered a mechanism by which an area of a protein shape-shifts to convert vitamin A into a form usable by the eye’s light-sensing photoreceptor cells.
Scientists have discovered a mechanism by which an area of a protein shape-shifts to convert vitamin A into a form usable by the eye’s light-sensing photoreceptor cells.
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