Researchers have found that genetic mutations affecting the capsid, the structure surrounding the HIV genome, make it possible for a protein called TRIM5α to trigger the immune system of elite controllers.
In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren’t likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy (ART). ART is a regimen containing combinations of HIV-targeting drugs that prevents the growth of the virus but does not eradicate it.
Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small numbers, the data suggest that long-term viral remission might be possible for more people.
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains. The study, published today in Nature, reveals for the first time how the Alzheimer’s-linked gene, APP, is recombined by using the same type of enzyme found in HIV.
The abundance of personal smartphones in southern African countries got University of Washington professor Sarah Gimbel thinking: What if these phones were used by front-line health workers — namely nurses — to collect and analyze data on patients living with HIV or AIDS to improve their care?
A new study by researchers of disease transmission in bats has broad implications for understanding hidden connections that can spread diseases between species and lead to large-scale outbreaks.
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure
Project LifeSkills, a behavioral intervention to prevent HIV in young transgender women, was designated by the HIV/AIDS Prevention Research Synthesis (PRS) project at the U.S. Centers for Disease Control and Prevention (CDC) as showing the best evidence of efficacy.
The MidAtlantic AIDS Education and Training Center (MAAETC) will collaborate with UPMC and local HIV stakeholders to host an all-day educational forum to celebrate the 30th Anniversary of World AIDS Day and the 30th Anniversary of the MAAETC.
This month's Fred Hutch tip sheet includes story ideas about understanding how skin stops tumor growth, advances in studying Kasposi sarcoma, and forecasting the flu. To pursue any of these stories ideas, contact the person listed.
“Think globally, act locally” is a popular global health idea that encourages people to consider the health of the entire planet while taking actions in their own cities and communities. And it’s an idea that inspired a group of students in the Perelman School of Medicine to join with other medical schools in Philadelphia and start a group dedicated to the growing field of global surgery. Until recently, surgery has been largely omitted from global health efforts, taking a back seat to infectious diseases like HIV/AIDS, tuberculosis, and malaria. But as progress is made to treat and prevent these diseases, it has become clear that there is a significant need to focus on treating people in resource-limited settings who are in need of surgical care. And this need touches almost every aspect of health care from cancer to obstetrics to orthopedics. In fact, according to the Lancet Commission on Global Surgery, more than 18 million people die each year from lack of surgical care.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
Biologists have discovered a new way of re-sensitizing drug-resistant tumor cells to DNA-damaging agents, the most widely used group of cancer drugs. Researchers describe how a gene known as Schlafen 11 controls the sensitivity of tumor cells to DDAs. Their research may pave the way to new strategies to overcome chemotherapeutic drug resistance.
In this issue, find research on infant sugary drink consumption, China's top 20 health challenges, aging and healthy years in the Netherlands, and increasing opioid use in Massachusetts
Audio from the American Neurological Association’s 143rd Annual Meeting media roundtable, held October 22, 2018, is now available. At the roundtable, presenters of the meeting’s six principal symposia presented highlights, discussed the relevance of the work, and answered questions.
The Midwest AIDS Training and Education Center (MATEC) at the University of Illinois at Chicago has received $4.4 million in funding from the federal government to advance its work improving HIV/AIDS care, prevention and education in Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, Ohio and Wisconsin.
FINDINGS Infants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection. The researchers found that 23 percent of the infants who became infected with HIV during the mother’s pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.
Fear never works. Or does it? Fear can be a powerful tool in public health efforts, although graphic, emotionally evocative campaigns have been the source of controversy over the past half-century.
Researchers at the UNC School of Medicine have been awarded a 5-year, $3.8 million grant from the National Institute of Allergy and Infectious Diseases to develop next generation, ultra-long-acting antiretroviral formulations for HIV treatment and prevention that have the potential to dramatically improve adherence.
Currently, a once-daily pill to prevent HIV infection is available. However, adherence to a once-daily regimen can be difficult for some people. Researchers from the UNC School of Medicine and the Centers for Disease Control and Prevention published a study today in Nature Communications that reports a potentially promising remedy for this problem.
A team of nurses and physicians has received a four-year, $3 million grant from the National Heart, Lung, and Blood Institute to extend traditional HIV treatment protocols to improve the cardiovascular health of people living with HIV.
Scientists from the Cancer Science Institute of Singaporeat the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.
The University of Illinois at Chicago is one of eight universities awarded funding by the National Institutes of Health to prevent and treat sexually transmitted infections, including HIV, among adolescents and young adults in Africa and Brazil. Collectively, the international projects are known as Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H).
he Sorenson Impact Center’s University Venture Fund - Impact Investing (UVF II) closed its first investment in a seed round into Salt Lake City-based Navigen, Inc.
A new study, focusing on a small molecule called IP6 and the role it plays in the HIV life cycle, "opens a door for development of new treatments."
In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus.
Providers in states that expanded Medicaid were more likely to believe that the law would improve HIV outcomes, the study found. However, providers in all states agreed that the law would improve healthcare outcomes in general for their HIV patients.
Nigerian youth are at the epicenter of an expanding HIV crisis in Sub-Saharan Africa. HIV testing is an important early entry point to accessing preventive education, care and treatment. Yet fewer than one in five Nigerian youth have been tested. A Saint Louis University study seeks to change this by developing and implementing Innovative Tools to Expand HIV Self-Testing (I-TEST) for at-risk youth ages 14-24.
Joyce Anastasi, PhD, DrNP, FAAN, Independence Foundation Professor at NYU Rory Meyers College of Nursing, was awarded a $3.5 million grant by the National Institutes of Health (NIH) to study whether stimulating acupuncture points can help manage HIV-related neuropathic pain.
Nearly 2.3 million times last year, Americans learned they had a sexually transmitted disease. But despite these record-high infection rates for chlamydia and gonorrhea, most patients only receive treatment for their own infection – when they probably could get antibiotics or a prescription for their partner at the same time. A team of physicians examines the barriers that stand in the way of getting expedited partner therapy to more people.
The NIH has awarded the UNC HIV Cure Center and Cell Microsystems a Small Business Innovation and Research contract to develop an automated platform to quantify the latent HIV reservoir, a key step in finding a cure for the virus.
Wistar scientists have applied their synthetic DNA technology to engineer a novel eCD4-Ig anti-HIV agent and to enhance its potency in vivo, providing a new simple strategy for constructing complex therapeutics for infectious agents as well as for diverse implications in therapeutic delivery.
The latest research, features and announcements in healthcare in the Healthcare News Source
A relatively simple effort to provide counseling and connect injection-drug users with resources could prove powerful against the spread of HIV in a notoriously hard-to-reach population, new research suggests.
Researchers at the University of North Carolina at Chapel Hill have found that crowdsourced campaigns can motivated men at-risk of HIV infection in China to get tested.
In this issue, find research on school shootings and long gun age restrictions, Russian anti-vaccine trolls, smoke-free colleges and more.
Using the BioSANS instrument at DOE’s ORNL, a team of researchers from the University of Pennsylvania’s Perelman School of Medicine explores future HIV treatments. Specifically, the researchers hope to better understand how HIV evolves to combat ALLINIs, a new class of HIV-fighting drug. With the information they’ve gathered at ORNL, the researchers hope to pave the way for more effective HIV treatments in the future.
In a pair of new modeling studies, researchers at University of California San Diego School of Medicine, with international colleagues, examined how policy reform in terms of drug decriminalization (in Mexico) and access to drug treatment (in Russia) might affect two regions hard hit by the HIV pandemic: Tijuana, Mexico and the Russian cities of Omsk and Ekaterinburg.
An international research group, which included an ISU scientist, has proven that three proteins that can help prevent the spread of HIV can be expressed in transgenic rice plants. Using plants as a production platform could provide a cost-effective means of producing prophylactics, particularly in the developing world.
7th DC Metro Autoimmune Walk -- Linking Together for a Cure
New research provides details of how the structure of the HIV-1 virus is assembled, findings that offer potential new targets for treatment.
Using genetic sequencing to understand the evolutionary relationships among pathogens, an international team of researchers—including several from the Center for Drug Use and HIV/HCV Research (CDUHR) at New York University—has developed a new method to determine how effective interventions are against the spread of infectious diseases like HIV.
Johns Hopkins scientists report they have identified two potential new drug targets for the treatment of HIV. The finding is from results of a small, preliminary study of 19 people infected with both HIV—the virus that causes AIDS—and the hepatitis C virus. The study revealed that two genes—CMPK2 and BCLG, are selectively activated in the presence of type 1 interferon, a drug once used as the first line of treatment against hepatitis C.
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