Millions of Americans take drugs to reduce their risk of heart attacks caused by blood clots. A new study suggests that a fear of brain bleeding if these patients receive stroke therapy may be unfounded, at least for most patients taking common clot-preventing therapies.
A single dose of an investigational anti-inflammatory drug called inclacumab considerably reduces damage to heart muscle during angioplasty (the opening of a blocked artery), according to a recent international clinical trial spearheaded by Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute, affiliated with the University of Montreal.
While two large clinical trials recently showed that adding niacin to statin therapy failed to improve clinical outcomes despite a significant increase in HDL-C levels, little is known about exactly why the increased HDL-C levels did not reduce the risk of cardiovascular events, including heart attack and stroke. Now, a small study from researchers the Perelman School of Medicine at the University of Pennsylvania, has shown that while niacin increased measured levels of HDL-C, it did not improve the functionality of HDL. This may provide an explanation for the failure of niacin to further reduce cardiovascular risk. The study results were reported today at the 62nd Annual Scientific Session of the American College of Cardiology in San Francisco.
New research from a multidisciplinary team at the Perelman School of Medicine at the University of Pennsylvania has shown that the combination of CPAP and weight loss for patients with OSA can help lower blood pressure better than either therapy alone. The study results were reported today at the 62nd Annual Scientific Session of the American College of Cardiology in San Francisco.
Researchers show how fish oils help lower blood pressure via vasodilation at ion channels. In vascular smooth muscle cells, such as those that line blood vessels, ion channels that span the outer membrane of a cell to let such ions as sodium, calcium, and potassium in and out, are critical to maintaining proper vessel pressure.
A study that analyzed data from more than 82,000 veterans suggests that infection with the human immunodeficiency virus (HIV) was associated with an increased risk of acute myocardial infarction (AMI, heart attack) beyond what is explained by recognized risk factors, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.
As most people know, there are many differences between men and women (to say the least). But what if acknowledging those differences could save a life.
A treatment that's similar to kidney dialysis is removing cholesterol from the blood of patients who cannot control cholesterol through diet, exercise and medications.
An abdominal aortic aneurysm — a bulge in the large artery that carries blood away from the heart — can be immediately life-threatening if it grows large enough to rupture. The chance of survival when it ruptures is less than 10 percent.
Many who find out they have that risk are able to have a minimally invasive repair. But up to 30 percent instead face a major open operation because of the location of the aneurysm. This new customized graft allows them, too, to have a quick recovery.
Even after successful treatment, patients with Cushing’s disease who were older when diagnosed or had prolonged exposure to excess cortisol face a greater risk of dying or developing cardiovascular disease, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
Researchers have found a genetic variant that doubles the likelihood that people will have calcium deposits on their aortic valve. Such calcification, if it becomes severe, can cause narrowing or a blockage of the aortic valve, a condition called aortic stenosis. The study is the first large-scale, genome-wide association study to uncover a genetic link to aortic valve calcification. An article detailing the findings is published in the February 7, 2013 issue of The New England Journal of Medicine.
Although heart disease remains the No. 1 killer nationally for women—responsible for one out of every three deaths—many of today’s women still underestimate the seriousness of the disease and their risks, says Liliana Cohen, MD, a board-certified cardiologist with The Robert Wood Johnson Medical Group.
A new study, to be published in the Feb. 7, 2013 issue of the American Journal of Human Genetics, expands and deepens the biological and genetic links between cardiovascular disease and schizophrenia. Cardiovascular disease is the leading cause of premature death among schizophrenia patients, who die from heart and blood vessel disorders at a rate double that of persons without the mental disorder.
New evidence shows the root of heart failure lies in misfolded proteins in the heart’s cells, according to University of North Carolina School of Medicine researchers. The finding may pave the way for dramatically new treatment approaches.
Healthy men and women show little difference in their hearts, except for small electrocardiographic disparities. But new genetic differences found by Washington University in St. Louis researchers in hearts with disease could ultimately lead to personalized treatment of various heart ailments.
Experts from The Children’s Hospital of Philadelphia were among the leaders of two large national studies showing that extending CPR longer than previously thought useful saves lives in both children and adults after in-hospital cardiac arrest.
Many people who suffer from chronic kidney disease progressively lose their kidney function over time and eventually develop a condition called end-stage renal disease – the complete failure of the kidneys – placing them in need of lifelong dialysis or a kidney transplant.
In the Jan. 8 issue of Cell Metabolism, Vanderbilt's Jens Titze and his colleagues report that – in contrast to the prevailing dogma – sodium levels fluctuate rhythmically with 7-day and monthly cycles. The findings, which demonstrate that sodium is stored in the body, have implications for blood pressure control, hypertension and salt-associated cardiovascular risk.
People taking the blood pressure drugs called beta blockers may be less likely to have changes in the brain that can be signs of Alzheimer’s disease and other types of dementia, according to a study released today that will be presented at the American Academy of Neurology’s 65th Annual Meeting in San Diego, March 16 to 23, 2013.
Researchers at the Technion have found that heart attack patients with breathing disorders such as sleep apnea may benefit from mild-moderate sleep-disordered breathing. The findings could suggest ways to rebuild damaged heart tissue.
Patients who quit smoking and took an aspirin and statin before undergoing treatment for blocked leg arteries were less likely to suffer a complication six months later, according to new research led by the University of Michigan Cardiovascular Center.
Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.
Researchers have pinpointed a molecular mechanism needed to unleash the heart’s ability to regenerate, a critical step toward developing eventual therapies for damage suffered following a heart attack.
A study published in the Journal of Clinical Investigation in November, traces hypertension to a newfound cellular source in the brain and shows that treatments targeting this area can reverse the disease.
It is quite common for patients who have had heart surgery to experience anxiety and short-term memory loss as side effects. New research from Ryerson University has found that heart-surgery patients experiencing these conditions are less successful at self-managing care and risk re-admission to hospital.
The study reports on the protective impact of healthy eating for individuals with cardiovascular disease who are taking medication to prevent a second heart attack, stroke or death.
Amid the frenzy of decorating, planning and shopping for the holidays, health may take a backseat. However, the stress brought on by these activities plus cold temperatures could lead to heart attacks or heart-related complications if left unchecked.
A new analysis of conflicting findings from hundreds of studies on the use of omega-3 fatty acids for cardiovascular disease finds that they do work, for this and other health concerns, and helps to explain some of the differing research results.
Digoxin, a drug widely used to treat heart disease, increases the possibility of death when used by patients with a common heart rhythm problem − atrial fibrillation (AF), according to new study findings by University of Kentucky researchers. The results have been published in the prestigious European Heart Journal, and raises serious concerns about the expansive use of this long-standing heart medication in patients with AF.
Researchers at Case Western Reserve University School of Medicine have identified a genetic factor that prevents blockages from forming in blood vessels, a discovery that could lead to new therapies for cardiovascular diseases.
The findings are described in the Nov. 19 issue of the Journal of Clinical Investigation.
Cardiovascular disease will kill nearly 2.5 million people in the United States this year, according to the Centers for Disease Control. Over time, inflammation, collagen deposition and scar tissue formation can cause blood vessels to stiffen, a process called vascular fibrosis. Though researchers have known that the hormone aldosterone (Aldo) plays a role in this process, the precise mechanisms have been poorly understood.
Age at onset of menarche (first menstrual cycle) is associated with increased body mass index (BMI), waist circumference, and overall obesity in adulthood, according to a recent study.
The presence of autoantibodies in the blood may be connected to a higher risk of the development of cardiovascular disease, not just in individuals with diagnosed autoimmune diseases like rheumatoid arthritis, but in the general population, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Washington, D.C.
Researchers at The Methodist Hospital Center for Cardiovascular Disease Prevention and the Baylor College of Medicine presented new data today that show two biomarkers can improve heart failure risk prediction as part of a simpler model.
Heart failure patients with a condition called “heart block” derive significant benefit from cardiac resynchronization therapy (CRT), according to the results of the Block HF clinical trial, presented today at the American Heart Association Scientific Sessions 2012 meeting in Los Angeles.
An international, clinical research trial has shown that patients with diabetes whose multi-vessel coronary artery disease is treated with bypass surgery live longer and are less likely to suffer severe complications like heart attacks than those who undergo angioplasty.
Research by Johns Hopkins cardiologists suggests that electrocardiograms (ECGs), which are widely used tests to assess the heart’s electrical activity, may have a greater and more profound future role in predicting the risk of death from any cause, not just heart problems.
In a study initially designed to determine which patients with heart failure were at highest risk of a dangerous heart rhythm disorder called ventricular tachycardia, and death, the researchers analyzed the ECGs of 850 patients using a new computer algorithm that detects abnormal heart rate patterns. They found a significant correlation between the ECG findings using the special analysis and the patients who died within five years of the test.
Black men and women have twice the risk of fatal coronary heart disease as whites, but the disparity could be eliminated with better risk factor control.