When older adults with cancer take multiple medications — including ordinary drugs like blood pressure pills, supplements, or antacids — it can result in more toxic chemotherapy side effects and even a need to stop cancer treatment.
Expert from Rutgers Cancer Institute of New Jersey & RWJBarnabas Health discusses what young people should know about colorectal cancer as the disease continues to rise in those ranging in age from mid-20's to 50's.
An interdisciplinary collaboration 10 years in the making used a materials science approach to “fingerprint” the calcium mineral deposits known as microcalcifications that reveal pathological clues to the progression of breast cancer and potentially other diseases.
This study shows vaccination against COVID-19 is an essential strategy to improve outcomes in this high-risk population. The results support guidelines that patients with cancer should receive at least 3 COVID-19 vaccine doses.
UC San Diego researchers report that a late-stage, pre-clinical small molecule inhibitor reverses malignant hyper-editing by a protein that promotes silencing of the immune response, metastasis and therapeutic resistance in 20 different cancer types.
When designing strategies to create lasting impact in a particular community, there is no better resource than the strength and intelligence of the community members themselves, and in this case, girls and women. Using crowdsourcing as a framework, a Saint Louis University researcher aims to increase HPV vaccination and HPV screening to lower incidents of cervical cancer among girls and women in Nigeria.
Researchers at The University of Texas MD Anderson Cancer Center have identified CD70 as being highly expressed on drug-resistant cancer cells in EGFR-mutant non-small cell lung cancer (NSCLC), highlighting a novel therapeutic target that could be used to eliminate resistant cells remaining after treatment with commonly used EGFR tyrosine kinase inhibitors (TKIs). The study published today in Cancer Cell.
In a new study published in the journal Cancer Immunology Research, our researchers, led by Amer A. Beg, Ph.D., show how stimulating dendritic cells through the CD40 and interferon β (IFNβ) pathways produces strong T cell activity against tumors and works in conjunction with immune checkpoint inhibitors to produce even stronger responses. The article also shares promising early results from a phase 1 clinical study of an oncolytic virus (MEM-288) that activates these pathways in patients with non-small cell lung cancer.
People who are unemployed due to brain or spine cancer may experience more severe symptoms of pain, discomfort, anxiety and depression than people with these cancers who are employed, according to a study published in the February 8, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Utilizing artificial intelligence (AI) along with traditional pathology offers promise for swiftly developing treatment plans for patients with non-small cell lung cancers, a team led by UT Southwestern Medical Center researchers discovered.
With a new five-year, $3.03 million grant from the National Cancer Institute—an agency of the National Institutes of Health—Case Western Reserve University researchers are leading the development and commercialization of a novel MRI and software technology that results in more accurate, consistent brain tumor diagnosis.
Mulheres com câncer em uma das mamas podem ter um risco mais elevado de desenvolver câncer na mama oposta caso sejam portadoras de mutações genéticas que as predisponham ao desenvolvimento de câncer de mama, de acordo com um estudo conduzido pelo Centro de Câncer da Mayo Clinic.
وفقًا لدراسة قادها مركز مايو كلينك الشامل للسرطان، فإن النساء المصابات بالسرطان في إحدى الثديين قد يكن أكثر عرضة للإصابة بالسرطان في الثدي الآخر إذا كنَّ حاملات لتغيرات جينية بعينها تجعلهن أكثر قابلية للإصابة بسرطان الثدي. يقول مؤلفو الدراسة إن النتائج المنشورة في مجلة مجلة علم الأورام السريرية، ستساعد في تخصيص أساليب فحص سرطان الثدي وتحديد عوامل الخطر وفقًا لحالة المريضة.
Risk model-based lung cancer screening strategies, which select individuals based on personal risk, are more cost effective than current recommendations based solely on age and smoking history, according to a study led by the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Working Group, which includes researchers from The University of Texas MD Anderson Cancer Center.
For the first time, researchers have discovered that prostate cancer can be killed by targeting a single enzyme. The findings could help address the growing threat of prostate cancer resistance and could also lead to improved treatments for other cancers.
UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.
A new UC Davis study reveals the interaction between tumor microbiome and the immune system may be the secret to improving outcomes for sarcoma patients.
Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.
In an academic-industrial collaboration, Mayo Clinic is assessing in a clinical trial a new radiotracer in pancreatic cancer imaging.
A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a new computational tool that can more accurately discover and quantify RNA molecules from these error-prone long-read RNA sequencing data. The tool, called ESPRESSO (Error Statistics PRomoted Evaluator of Splice Site Options), was reported today in Science Advances.
Moffitt Cancer Center researchers have developed a tool to determine how a new class of prostate cancer therapies called radionuclide therapy (RNT) impacts patient-reported outcomes with the goal of using this information to guide treatment and improve quality of care. Their findings have been published in The Journal of Nuclear Medicine.
Columbia researchers invent a multimodal sequencing technique that achieves high-quality results from small volumes of frozen tumor specimens--the ability to study cancer tissues archived in biobanks should increase the number and variety of tumor samples available for scientific analysis and advance the discovery of biomarkers and drug targets.
National Comprehensive Cancer Network’s new Diversity, Equity, & Inclusion (DEI) Directors Forum is working together to improve diversity of clinical staff representation across nation’s leading academic cancer centers.
Physician experts from Rutgers Cancer Institute of New Jersey and RWJBarnabas Health will be presenting the latest innovations in the study, diagnosis and treatment of gastrointestinal cancers at the ASCO GI Cancers Symposium from January 19-21.
LA JOLLA, CA — Researchers at La Jolla Institute for Immunology (LJI) have at last uncovered how an enzyme called O-GlcNAc transferase (OGT) keeps cells healthy. Their findings, published in the Proceedings of the National Academies of Sciences, reveals a key aspect of cellular biology and may lead to important medical advances.
A new University of Kentucky Markey Cancer Center study highlights the need for increased outreach and education to reduce colorectal cancer screening disparities in Black communities. According to the qualitative study published in the Journal of Cancer Education, people in Kentucky’s Black communities may not be aware about all of the colorectal cancer screening options available to them, particularly stool-based tests.
Findings from a UC Davis Comprehensive Cancer Center study prompt researchers to question current cervical cancer screening guidelines for older women.
Researchers at The University of Texas MD Anderson Cancer Center have discovered a novel immunotherapy combination, targeting checkpoints in both T cells and myeloid suppressor cells, that successfully reprogrammed the tumor immune microenvironment (TIME) and significantly improved anti-tumor responses in preclinical models of pancreatic cancer.
UT Southwestern researchers have identified the molecular function of 87 inherited genetic variants that affect the risk of prostate cancer, and the majority appear to control the activity of genes located far away from the risk variants themselves.
NIBIB-funded researchers are developing a new method to treat pancreatic cancer. In their study, they combined an injectable radioactive gel with systemic chemotherapy in multiple mouse models of the disease. The treatment resulted in tumor regression in all evaluated models, an unprecedented result for this genetically diverse and aggressive type of cancer.
A new study looks at cancer deaths in California due to tobacco, sounding the alarm regarding the tragic loss of life caused by tobacco addiction
Study uncovers the genomic features of Richter's and how it emerges from CLL Researchers identify molecular subtypes of Richter's and y show that, in some cases, Richter's can be detected in a blood test, rather than a biopsy, potentially leading to earlier treatment.
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While people with cancer have options to participate in cancer clinical trials (CCTs), it can be challenging when they encounter difficulties enrolling and remaining in the trial. Trial withdrawal, although every participant’s right, can thwart study goals and hamper advancing novel treatments.
Laura Fejerman named new associate director for cancer center’s Office of Community Outreach and Engagement as Moon Chen heads new cancer screening program.
Moffitt Cancer Center researchers are working to develop smoking cessation tools and improve access for Spanish-speaking smokers. In a new article published in Annals of Family Medicine, Moffitt researchers report that proactively connecting Spanish-speaking patients with tobacco treatment delivered by state Quitlines leads to dramatic improvements in treatment enrollment and smoking cessation outcomes.
Three currently circulating omicron subvariants of SARS-CoV-2 – including two that currently make up almost 50% of reported COVID-19 infections in the U.S. – are better at evading vaccine- and infection-generated neutralizing antibodies than earlier versions of omicron, new research suggests.
A team of researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) has made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.
Researchers have demonstrated in mice a new approach for delivering medication across the blood-brain barrier to treat tumors that cause aggressive, lethal brain cancer.
TEAMSPORT will create a standardized approach to ordering genomic tests and adapt it for use in community cancer centers, where most cancer patients receive testing and treatment.
A new study by Cedars-Sinai investigators describes risk factors that could make it more likely for people who have chronic pancreatitis, an ongoing inflammation of the pancreas, to develop diabetes. The findings are published in Diabetes Care.
Two new studies from researchers at Fred Hutchinson Cancer Center in Seattle reveal how bacteria infiltrate tumors and could be helping tumors progress and spread and suggest a link between oral health and cancer, as microbes in the mouth are associated with cancers elsewhere in the body. The two papers – one published Nov. 15 in Cell Reports and the other published Nov. 16 in Nature – focus on an oral bacterium called Fusobacterium nucleatum, which has been linked to colorectal cancer.
A brisk walk for 20 minutes a day may not sound like much, but it could make a big difference for colorectal cancer patients. Regular physical activity reduces inflammation by improving the gut microbiome of patients, including patients who are obese, scientists at Huntsman Cancer Institute found. They researched the impact of exercise on the gut microbiome, the trillions of bacteria that live in our digestive system. Investigators found moderate exercise improved outcomes in colorectal cancer, the third most common cancer in the United States, excluding skin cancers. Scientists explain why their findings are so significant.
Joseph A. Califano III, MD, has been named director of Moores Cancer Center at UC San Diego Health.
Penn Medicine experts have worked with local partners to improve health care in Botswana for years. Now, a new $3.5 million grant from the NCI will help further that work by addressing one of Botswana’s most serious health challenges: cervical cancer.
A team of researchers at The University of Texas MD Anderson Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy. The preclinical findings suggest this adaptable immune conversion approach has the potential for broad application across many cancer types.
Can mind-body practices such as gentle yoga or self-reflection benefit patients undergoing surgery? It’s a question that researchers at Wake Forest University School of Medicine are examining with the support of a five-year, $3.2 million grant from the National Cancer Institute (NCI).
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