Feature Channels: Parkinson’s Disease

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A reason for these findings could be due to the fact that Parkinson's patients often also have many risk factors for a severe course of Covid-19.

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For the first time, Cornell University researchers have developed a technique for studying the neuroscience of motor control in mice ¬– by focusing on a mouse’s tongue when it licks a water spout.

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Parkinson’s disease is the second most common neurodegenerative disease and affects more than 10 million people around the world. To better understand the origins of the disease, researchers from Penn State College of Medicine and The Hebrew University of Jerusalem have developed an integrative approach, combining experimental and computational methods, to understand how individual proteins may form harmful aggregates, or groupings, that are known to contribute to the development of the disease.

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VGLUT – a glutamate transporter on the membrane of vesicles that carry dopamine – is key to regulating sex differences in the brain’s vulnerability to age-related neuron loss.

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As part of a five-year, $2 million NSF project, Georgia Tech researchers uncover new methods for using sound and vibration to treat and diagnose brain diseases. The research could eliminate reliance on MRIs, paving the way for less costly and simpler systems that could serve a wider population.

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New research shows evidence of inflammation in the blood of Parkinson’s disease patients during the earliest stages of the disease, lending support to theories that inflammation is a major driver of PD. The study also points out differences between the sexes in the symptoms and course of the disease.

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Altered neural functioning, like that experienced in patients with Parkinson’s disease, changes the way art is both perceived and valued. People with neurological motor dysfunction demonstrated decreased experiences of motion in abstract art and enhanced preferences for high-motion art, compared to a healthy control group.

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ACS Spring 2021 Press Conference Schedule Watch live and recorded press conferences at http://www.acs.org/acsspring2021conferences. Press conferences will be held Monday, April 5 through Friday, April 16, 2021. Below is the schedule, which will be updated as needed.

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A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, according to University of Utah Health scientists.

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A Phase II clinical trial to assess mesenchymal adult stem cells as a disease-modifying therapy for Parkinson's disease has been launched at The University of Texas Health Science Center at Houston (UTHealth).

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New research from the Florida State University College of Medicine has found that the personality trait neuroticism is consistently associated with a higher risk of developing the brain disorder Parkinson’s disease. The research by Professor of Geriatrics Antonio Terracciano and team, published in Movement Disorders, found that adults in the study who scored in the top quartile of neuroticism had more than 80% greater risk of Parkinson’s, compared to those who scored lower on neuroticism.

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A clinical trial to assess the safety and efficacy of stem cell therapy for treatment-resistant bipolar depression launched recently at The University of Texas Health Science Center at Houston (UTHealth).

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For nearly 50 years, doctors have recognized that Parkinson’s disease patients have an increased risk of melanoma. Now, scientists report a link between the two diseases in the form of protein aggregates known as amyloids. They will present their results at ACS Spring 2021.

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In addition to smoothing out wrinkles, researchers have found that the drug Botox can reveal the inner workings of the brain. A new study used it to show that feedback from individual nerve cells controls the release of dopamine, a chemical messenger involved in motivation, memory, and movement.

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Scientists have created a connectivity map from a brain hub that regulates motor and behavior functions. The connections could open avenues for intervention of Parkinson’s disease and other disorders such as Tourette’s syndrome, ADHD and obsessive-compulsive disorder.

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Neurobiologists have found that identifiable brain pathways are linked with specific debilitating symptoms of Parkinson’s disease. The findings could help form the basis for improving therapeutic strategies for precise symptoms of Parkinson’s at various levels of disease progression.

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Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days. The groundbreaking study provides new insight into fundamental research that could improve human brain conditions such as concussions, autism, Alzheimer’s, and Parkinson’s disease, as well as better understanding the brain’s role in addiction.

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For people with Parkinson’s disease, problems with thinking and memory skills are among the most common nonmotor symptoms of the disease. A new study shows that exercise may help slow cognitive decline for some people with the disease. The study is published in the March 31, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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First-of-its kind technology allows Rush doctors to remotely deliver a digital prescription for patients with brain stimulation therapy for Parkinson’s Disease and Essential Tremor.

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Scientists report a novel noninvasive treatment for brain disorders based on breakthroughs in both optics and genetics. It involves stimulation of neurons by means of radioluminescent nanoparticles injected into the brain and exposed to X-rays.

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A pioneering study, published in Scientific Reports, found that the Parkinon's gene PINK1 is important for the generation of dopamine-producing neurons throughout life, and is not just responsible for the premature death of these neurons.

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In APL Bioengineering, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments. They are urging their colleagues to remember those differences when researching treatments and cures.

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Results published today show it is possible to identify Parkinson's based on compounds found on the surface of skin.

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When it comes to exercise that does the most good for people with Parkinson’s disease, golf may hit above par when compared to tai chi. That’s according to a preliminary study released today, March 3, 2021, that will be presented at the American Academy of Neurology’s 73rd Annual Meeting being held virtually April 17 to April 22, 2021. The study found that golf was better than tai chi for improving balance and mobility.

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Grafting neurons grown from monkeys’ own cells into their brains relieved the debilitating movement and depression symptoms associated with Parkinson’s disease, researchers at the University of Wisconsin–Madison reported today.

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The Parkinson's Disease and Movement Disorder Center at Henry Ford Health System was the first in the United States to offer a new FDA-approved device to help treat the symptoms of Parkinson's disease. Neurosurgeon Jason Schwalb, M.D. surgically implanted the Vercise Genus™ Deep Brain Stimulation (DBS) System, which stimulates a targeted region of the brain through implanted leads that are placed in the brain.

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No matter where you are in the world, the 2021 AAN Annual Meeting is one click away. Journalists can now register to attend the 73rd Annual Meeting of the American Academy of Neurology (AAN) being held virtually April 17-22, 2021. The AAN Annual Meeting is the world’s largest gathering of neurologists who come together to share the latest advances in neurologic research.

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Five genes may play a key part in influencing if a person will contract Lewy body dementia, and possibly dementia from Parkinson's and Alzheimer’s diseases, according to a study published in Nature Genetics Feb. 15. The genes, BIN1, TMEM175, SNCA, APOE, and GBA, were identified by a team of scientists at the National Institute of Neurological Disorders and Stroke and the National Institute on Aging, National Institutes of Health, and sequenced by The American Genome Center (TAGC), a series of state-of-the-art laboratories at the Uniformed Services University of the Health Sciences.

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DALLAS – Feb. 11, 2021 – A study led by UT Southwestern has identified a mechanism that controls the activity of proteins known as chaperones, which guide proteins to fold into the right shapes. The findings, published online today in Nature Communications, could shed light on hundreds of degenerative and neurodegenerative diseases caused by protein misfolding, such as Alzheimer’s, Parkinson’s, and Huntington’s, potentially leading to new treatments for these devastating conditions.

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For the first time in humans, investigators at Cedars-Sinai have identified the neurons responsible for canceling planned behaviors or actions-a highly adaptive skill that when lost, can lead to unwanted movements.

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A new study from UBC researchers suggests a strong correlation between following the MIND and Mediterranean diets and later onset of Parkinson's disease (PD). While researchers have long known of neuroprotective effects of the MIND diet for diseases like Alzheimer's and dementia, this study is the first to suggest a link between this diet and brain health for Parkinson's disease (PD).

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A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson’s disease symptoms that are more severe on one side of the body, new research suggests.

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During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.

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A novel Alzheimer’s disease marker—coming early in progression of the condition—could open significant new fronts of research into possible therapies

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A hallmark of Parkinson's disease is the degeneration of a group of neurons in the brain that release the neurotransmitter dopamine (dopaminergic neurons)

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Research from UCLA scientists and colleagues from other institutions finds that people with Parkinson's disease who lack meaningful social interactions may be at an increased risk for severe symptoms related to the disease.

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We use recycled products every day. Money, for example, goes on a circular journey from our hands to banks and back again. Once paper money is too worn to be used, banks send it to be destroyed. A similar microscopic waste system is present in our brains, in which nervous system cells called neurons trade chemical messengers and remove the carriers they travel in when they become defective.

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Los investigadores de Mayo Clinic desarrollaron, junto con otros colaboradores a nivel mundial y nacional, una posible prueba para la enfermedad de Machado-Joseph o ataxia espinocerebelosa tipo 3, una afección que no tiene cura. También identificaron la función de un gen objetivo relacionado con la enfermedad.

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Lewy body dementia, also known as dementia with Lewy bodies, is a relatively frequent but often misunderstood form of dementia, which can cause loss of memory, language and problem-solving ability.

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During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.

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GRAND RAPIDS, Mich. (Oct. 22, 2020) — Can COVID-19 infection increase the risk of developing Parkinson’s disease?

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Traumatic brain injury (TBI) is a leading cause of cognitive impairment that affects millions of people worldwide. Despite growing awareness about the debilitating and lifelong progressive consequences of TBI, there are currently no treatments that slow the deteriorative process. TBI survivors are currently treated with extensive physical and cognitive rehabilitation, accompanied by medications that may mitigate symptoms yet do not halt or slow neurodegeneration. Now, researchers have found for the first time that this process can be pharmacologically reversed in an animal model of this chronic health condition, offering an important proof of principle in the field and a potential path to new therapy.

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New research shows a simple skin test can accurately identify Parkinson’s disease, which could lead to earlier detection of the disease and better outcomes for patients. Currently, Parkinson’s disease is diagnosed by clinical signs and symptoms but only definitively diagnosed at autopsy. The researchers conducted a blinded study of 50 skin samples using an assay originally designed to detect mad cow disease.

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Dopamine and serotonin are at work at sub-second speeds to shape how people perceive the world and take action based on their perception. The discovery shows researchers can simultaneously measure the activity of both dopamine and serotonin in disorders ranging from depression to Parkinson’s disease.

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Researchers at Case Western Reserve University School of Medicine seek to optimize emerging methods of diagnosing two common neurodegenerative diseases—dementia with Lewy bodies and Parkinson’s disease dementia—which affect 1.4 million in the United States

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A Rush team of neurological and neurosurgical clinicians is the first in Illinois and among the first in the United States to offer an innovative, noninvasive treatment for medication-refractory tremor: MR-guided focused ultrasound.

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A team of researchers from the University of Notre Dame, Johns Hopkins University, Ohio State University and the University of Florida has identified networks of genes that regulate the process responsible for determining whether neurons will regenerate in certain animals, such as zebrafish.

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