Effects of Phthalate Exposure and an In Vitro Solution to Studying Structural Cardiotoxicity Are Featured in New ToxSci

Newswise — The September 2023 issue of Toxicological Sciences includes ToxSpotlight articles on how exposure to a specific phthalate may tamper with the ovarian insulin-like growth factor 1 system, affecting the reproductive health of female mice, and on a new high-throughput assay that may provide an in vitro solution to studying structural cardiotoxicity. The issue also features an In-Depth Review that examines the taxonomic domain of applicability in a cross-species adverse outcome pathway network for thyroid hormone system disruption.

• In-Depth Review: “Cross-Species Applicability of an Adverse Outcome Pathway Network for Thyroid Hormone System Disruption” (topic category: in-depth review)
• ToxSpotlight Article: “Human-Relevant Exposure to di-n-butyl Phthalate Tampers with the Ovarian Insulin-Like Growth Factor 1 System and Disrupts Folliculogenesis in Young Adult Mice” (free to read; topic category: developmental and reproductive toxicology)
• ToxSpotlight Article: “CardioMotion: Identification of Functional and Structural Cardiotoxic Liabilities in Small Molecules through Brightfield Kinetic Imaging” (free to read; topic category: emerging technologies, methods, and models)

Other papers in the September 2023 issue (sorted by topic category) are:

Carcinogenesis

• “Role of Nrf2 in 1,2-Dichloropropane-Induced Cell Proliferation and DNA Damage in the Mouse Liver”

Developmental and Reproductive Toxicology

• “Prenatal Exposure to Diethylstilbestrol Has Long-Lasting, Transgenerational Impacts on Fertility and Reproductive Development” (open access)

Environmental Toxicology

• “IL33-Mediated NPM1 Promotes Fibroblast-to-Myofibroblast Transition via ERK/AP-1 Signaling in Silica-Induced Pulmonary Fibrosis”

Genetic and Epigenetic Toxicology

• “CircRNA hsa_circ_0000043 Acts as a miR-4492 Sponge to Promote Lung Cancer Progression via BDNF and STAT3 Expression Regulation in Anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-Transformed 16HBE Cells”

Neurotoxicology

• “Machine Learning Reveals Common Transcriptomic Signatures across Rat Brain and Placenta Following Developmental Organophosphate Ester Exposure”

Organ Specific Toxicology

• “Lead Exposure Suppresses the Wnt3a/β-catenin Signaling to Increase the Quiescence of Hematopoietic Stem Cells via Reducing the Expression of CD70 on Bone Marrow-Resident Macrophages”

ToxSci Volume 195, Issue #1, as well as all past issues, is available on the ToxSci website.

About Toxicological Sciences The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology. The journal’s primary focus is on original research articles, but it also provides expert insight via contemporary, in-depth, and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field.

About the Society of Toxicology (SOT) Founded in 1961, SOT is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of scientists who practice toxicology around the world. The Society’s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology.