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Porpiglia and colleagues identify a dysfunctional CD47hi muscle stem cell (MuSC) subset in aged mice, which arises from increased U1 snRNA-driven CD47 alternative polyadenylation. CD47hi MuSCs trigger deleterious thrombospondin-1/CD47 signaling. A thrombospondin-1 antibody or a morpholino to the U1 site on CD47 restores aged MuSC function and muscle regeneration in vivo.
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