FL118, Drug Candidate Discovered at Roswell Park, Granted FDA Orphan Drug Status for Pancreatic Cancer

• Designation confers incentives supporting research on drugs for rare cancers
• FL118 originated from lab of Dr. Fengzhi Li at Roswell Park
• Pancreatic cancer projected to be 2nd leading cancer killer in U.S. by 2030

Newswise — BUFFALO, N.Y. — The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug Designation to Canget BioTekpharma LLC for FL118, a drug candidate developed at Roswell Park Comprehensive Cancer Center, as a possible treatment for pancreatic cancer.

FL118, also known by its chemical name, 10,11-methylenedioxy-20(S)-camptothecin (10,11-MD-CPT), is one of only 206 pharmaceutical agents granted Orphan Drug Designation for the treatment of pancreatic cancer since the FDA initiated the incentive program in 1984. 

Awarded to encourage development and evaluation of new treatments for rare diseases, orphan drug designation helps to speed and support research by providing investigators with incentives such as tax credits toward clinical trials, exclusive marketing rights and exemptions from user fees. Because they affect fewer people, rare diseases like pancreatic cancer typically are associated with limited treatment options, with fewer drugs in development compared to more-common diseases. 

While pancreatic cancer accounts for only about 3% of all cancers in the U.S. today, it has been projected to become the second most common cause of cancer-related U.S. deaths before 2030.

Discovered by a team of scientists led by Fengzhi Li, PhD, Associate Professor of Oncology in the Department of Pharmacology and Therapeutics at Roswell Park, FL118 has been shown in preclinical studies to eliminate both pancreatic and colorectal tumor cells by binding to DDX5, a powerful cancer-causing protein. It’s a small molecule derived from camptothecin, a component found in the bark and stem of a tree native to China — and used as a traditional Chinese remedy for centuries.

Canget BioTekpharma is a Roswell Park spinoff company formed by Dr. Li and partners to develop FL118.

Research recently published by Dr. Li and colleagues in the American Chemical Society’s Journal of Medicinal Chemistry documents the synthesis, identification and characterization of new analogs of FL118 shown to have enhanced comparative antitumor activity. Read more in “From the Forest: Researchers at Roswell Park are Utilizing a Novel Derivative of Camptothecin, an Antitumor Agent Found in Chinese Tree Bark,” on Roswell Park’s CancerTalk blog.

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From the world’s first chemotherapy research to the PSA prostate cancer biomarker, Roswell Park Comprehensive Cancer Center generates innovations that shape how cancer is detected, treated and prevented worldwide. Driven to eliminate cancer’s grip on humanity, the Roswell Park team of 4,000 makes compassionate, patient-centered cancer care and services accessible across New York State and beyond. Founded in 1898, Roswell Park was among the first three cancer centers nationwide to become a National Cancer Institute-designated comprehensive cancer center and is the only one to hold this designation in Upstate New York. To learn more about Roswell Park Comprehensive Cancer Center and the Roswell Park Care Network, visit www.roswellpark.org, call 1-800-ROSWELL (1-800-767-9355) or email [email protected].