Newswise — Therapeutics for Alzheimer’s disease are most likely to work if started early in the disease’s course, when amyloid plaques accumulate in the brain but memory is still intact. In their quest to recruit subjects in this preclinical disease state, clinicians must test people for AD risk factors such as brain amyloid accumulation or ApoE genotype, and then disclose that information to them so they can enroll in a trial. At the Alzheimer's Association International Conference, researchers presented early findings regarding the ethical, psychological, and societal impacts of such disclosure, and laid out their plans for the best ways to deliver the information. Cancer risk disclosure is more advanced, and guides their way. Beyond clinical trials, having smart disclosure procedures in place will be crucial if an AD therapy is approved, as then scores of people will want to get tested to head off the disease. Jessica Shugart examines the dilemma.
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