A team from the Salk Institute for Biological Studies and the University of California San Diego has, for the first time, profiled chemical modifications in the DNA of individual neurons, giving the most detailed information yet on what makes one brain cell different from its neighbor.
Researchers have developed a new methodology for identifying disease-causing genetic mutations in the non-coding region of the genome. This portion of the genome has remained uninterpretable until now.
Give your medicine a jolt. By using – electrochemistry – a technique that combines electricity and chemistry, future pharmaceuticals – including many of the top prescribed medications in the United States – soon may be easily scaled up to be manufactured in a more sustainable way.
For many, the commute to and from work is a lengthy, stressful process. According to the U.S. Census Bureau, it takes the average American about 26½ minutes to get to work. That’s nearly an hour each day — to work and back — to face traffic snarls and congested highways. That commute can also be hazardous to your health, exposing drivers to an increased amount of air pollutants that have been linked to a whole host of medical maladies, including cardiovascular disease, respiratory issues and even lung cancer.
Millions of people die every year from dehydration as a result of exposure and illness. In humans, even the most minor dehydration can compromise the kidneys causing lifelong, irreparable issues or even death. However, some animals living in desert environments are able to survive both acute and chronic dehydration. While these animals, like cactus mice, have evolved over time to deal with environmental stressors like dehydration, researchers at the University of New Hampshire have found it’s not the physical makeup that is helping them survive, but rather their genetic makeup.
This week, in a pair of papers published in Cell, researchers turned to an ant species — the Indian jumping ant -- that does not behave like most ants. In this species any female worker can change into a “pseudo-queen,” in the absence of the true queen and establish dominance on her colony. The teams genetically engineered this species in different ways using now-famous CRISPR technology that dramatically changed their social and reproductive behavior.
Until recently, CRISPR-Cas9 gene editing could only be used to manipulate DNA. In 2016, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9. In a study published August 10 in Cell, the team took RCas9 a step further: they corrected molecular mistakes that lead to microsatellite repeat expansion diseases, which include a type of ALS and Huntington's disease.
Cancer immunotherapies that block two different checkpoints on T cells launch immune attacks on cancer by expanding distinct types of T cell that infiltrate tumors, researchers from The University of Texas MD Anderson Cancer Center report in the journal Cell.
New research from the University of New Hampshire has led to the development of a novel technique to determine the surface area and volume of small particles, the size of a grain of sand or smaller. Due to their tiny size, irregular shape and limited viewing angle, commonly used microscopic imaging techniques cannot always capture the whole object’s shape often leaving out valuable information that can be important in numerous areas of science, engineering and medicine.
A third of insured people with cancer end up paying more out-of-pocket than they expected, despite having health coverage, researchers at the Duke Cancer Institute have found.
Science is fascinating to many, but sentences about research full of expert-level terms and descriptions can scare away even the most passionate audiences. Now, scientists have created a free, scientist-friendly “De-Jargonizer” they hope will make science and research accessible to the public.
A routinely used hospital tool can predict which liver transplant recipients are more likely to do poorly after surgery, according to a study led by Cedars-Sinai. The findings could help doctors identify which patients should receive physical therapy or other targeted interventions to improve their recovery.
A mathematician and computer scientist joined an international team of neuroscientists to create a complete map of the learning and memory center of the fruit fly larva brain, an early step toward mapping how all animal brains work.
Research was based on data from the START Birth Cohort study, which includes more than 1,000 women in their second trimester of pregnancy.
If you’re yearning for a better-tasting tomato juice, University of Florida scientists are in their labs, working on satisfying your palette. Essence, usually extracted from a plant to add flavor or provide a scent, according to a new UF/IFAS study, can be used to improve juice flavor.
A team of researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, Fla. and Mayo Clinic in Rochester, Minn. have been awarded a three-year National Institutes of Health(NIH) grant which aims to identify molecules that could become new medicines to inhibit myocardial fibrosis. Fibrosis is a major contributor to heart failure, for which there is no known cure.
Watching transgender characters on fictional TV shows has the power to influence attitudes toward transgender people and policy issues.
USB connections, the most common interface used globally to connect external devices to computers, are vulnerable to information ‘leakage’, making them even less secure than has been thought, Australian research has shown.
Parents of very premature or very low birth weight babies have the same life satisfaction as parents of full-term babies, when their children reach adulthood– according to new research by the University of Warwick.
A new study analyzing the security hygiene of common, open-source DNA processing programs finds evidence of poor computer security practices used throughout the field. In a scientific first, the UW team also demonstrated it is possible to compromise a computer system with a malicious computer code stored in synthetic DNA.
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