Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for approximately one in every three deaths, with more than 20 million deaths reported in 2021 according to a 2024 World Heart Federation report.
ChatGPT-4, an artificial intelligence program designed to understand and generate human-like text, outperformed internal medicine residents and attending physicians at two academic medical centers at processing medical data and demonstrating clinical reasoning. In a research letter published in JAMA Internal Medicine, physician-scientists at Beth Israel Deaconess Medical Center (BIDMC) compared a large language model’s (LLM) reasoning abilities directly against human performance using standards developed to assess physicians.
In a paper published in the Journal of the American Medical Association (JAMA), neurologists at Beth Israel Deaconess Medical Center (BIDMC) showed that a simple skin biopsy test detects an abnormal form of alpha-synuclein, the pathological hallmark of Parkinson’s disease and the subgroup of neurodegenerative disorders known as synucleinopathies, at high positivity rates.
In the largest randomized clinical trial and first of its kind to date in the United States, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) assessed the efficacy and safety of using a drug-coated balloon in patients undergoing coronary angioplasty.
Findings published in the journal Nature by physician-scientists at Beth Israel Deaconess Medical Center (BIDMC) and colleagues suggest that it may be possible to improve protection against COVID-19 by delivering the vaccine directly to the respiratory tract— the primary site of entry in SARS-CoV-2 infection.
Physician-investigators compared a chatbot’s probabilistic reasoning to that of human clinicians. The findings, published in JAMA Network Open, suggest that artificial intelligence could serve as useful clinical decision support tools for physicians.
New research helps explain the recent reversal in cardiovascular mortality among this population and underscores the need to address the social determinants of health that contribute to it.
Researchers performed complementary experiments showing that inhibiting a specific enzyme in a mouse model protects the dopamine-producing neurons that are normally lost as Parkinson's disease progresses, effectively halting the progression of the disease. The findings open the door to the development of novel therapeutics targeting the enzyme that may slow or prevent the progression of Parkinson's disease in people—a major unmet need.
A national study demonstrates that neighborhood exposure to environmental hazards is significantly associated with poor cardiovascular health across the United States.
With more than 4 million children placed into foster care during the study period, researchers used state-level data to evaluate the link between restricted abortion access and subsequent entries into the foster care system.
In a commentary published in a special Obstetrics & Gynecology issue on racism and reproductive health, corresponding author Rose L. Molina, MD, MPH, a BIDMC obstetrician-gynecologist, researcher, and activist advancing health equity in pregnancy care, discusses a long-standing pattern of reproductive control within the U.S. immigration enforcement system.
Researchers demonstrate that among individuals who were admitted to the hospital with COVID-19 and were discharged alive, the risk of post-discharge death was nearly twice that observed in those who were discharged alive from an influenza-related hospital admission.
Researchers present a completely new paradigm describing a developmental pathway by which the enteric nervous system development continues after birth.
Using an index to describe and compare frailty between older sexual and gender minority (OSGM) adults and non-OSGM participants, researchers showed that OSGM had higher rates of frailty, starting at younger ages and continuing into older age, compared to non-OSGM.
Researchers tested one well-known publicly available chatbot’s ability to make accurate diagnoses in challenging medical cases. The team found that the generative AI, Chat-GPT 4, selected the correct diagnosis as its top diagnosis nearly 40 percent of the time and provided the correct diagnosis in its list of potential diagnoses in two-thirds of challenging cases.
Researchers found that receiving intensive antihypertensive treatment as an inpatient was linked with greater risk of adverse events, particularly for patients receiving the medication intravenously as opposed to orally.
For nearly 25 years, Dr. James Kirby has worked to advance the fight against infectious diseases by finding and developing new, potent antimicrobials, and by better understanding how disease-causing bacteria make us sick. In a recent paper published in PLOS Biology, Kirby and colleagues investigated a naturally occurring antimicrobial agent discovered more than 80 years ago.
Researchers tested whether using open-label placebo could increase the efficacy of methadone treatment for people undergoing care for opioid use disorder.
Researchers estimated that climate change-related natural disasters have increased since 1980 and have already cost the United States more than $2 trillion in recovery costs. Their analysis also suggests that as atmospheric carbon dioxide levels and the global temperature continue to rise, the frequency and severity of disasters will increase, with recovery costs potentially rising exponentially.
In a retrospective cohort study of Medicare beneficiaries who underwent aortic stent grafting, researchers worked with the Food and Drug Administration (FDA) to compare the long-term outcomes of a specific endograft device type with comparative devices on the market.
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