Curious children and developmental biologists have long pondered the question: what makes a thumb a thumb, a pinky a pinky. The answer Wisconsin researchers have found may force scientists to revise theories of the way developing cells become fingers or spines (Science, 7-21-00).
Mere memory of drug use can alter an area of the brain -- the prefrontal cortex -- not traditionally implicated in addiction, say University of Wisconsin psychiatry researchers (Synapse, 8-00).
Armed with the strongest evidence to date, University of Wisconsin researchers have established that sleep apnea -- episodes of breathing pauses during sleep -- is likely to be an important cause of hypertension (NEJM, 5-11-00).
Researchers at the University of Wisconsin Medical School have found that mutations in a gene they've been studying for several years can cause ataxia-telangiectasia (A-T). The affected gene appears to play a crucial role in controlling the way cells respond to DNA damage.
Researchers in a small pilot study at the University of Wisconsin Medical School have found that protease inhibitors-- which have been key to lengthening survival for patients with HIV and AIDS -- may be linked to coronary artery disease.
Scientists know that a fuzzy fungus similar to the mold that grows on stale bread and over-ripe fruit produces lovastatin, the natural substance that lowers cholesterol in humans. Now pharmacy researchers at the University of Wisconsin-Madison know how the fungus makes it.
For the first time, researchers studying how the brain changes in the face of life's most basic and often difficult experiences will gather to discuss their latest findings at the Fifth Annual Wisconsin Symposium on Emotion, April 23-24, in Madison, WI.
Smokers taking the medication buproprion -- with or without nicotine patches -- were nearly twice as likely to have quit smoking one year later than those receiving patches alone or a placebo, according to a new study published in the New England Journal of Medicine.
A partnership between the first lady of Wisconsin, a leading tobacco researcher, health officials and a pharmaceutical company is bringing free smoking cessation aids and health information to 29,000 Wisconsin women, which has the nation's highest percentage of reproductive-age women who smoke.
Cells pay even closer attention to quality control of genetic information than scientists thought, according to findings by University of Wisconsin Medical School researchers. Before sending genetic molecules out of the nucleus to sites where they will function, cells check to see they are complete and ready to go.
Working from the intriguing case of a young recipient who showed little sign of graft rejection long after stopping anti-rejection drugs, scientists at University of Wisconsin Medical School have reported that kidney transplant success rates could be significantly improved by incorporating maternal tissue types into the donor selection process in the Dec. 3 New England Journal of Medicine.
A new study led by the University of Wisconsin Medical School has found that a medication now used for controlling seizures is also effective against the pain of diabetic neuropathy -- with fewer and less serious side effects.
Researchers at the University of Wisconsin-Madison and the NIH have determined the three dimensional molecular structure of a powerful enzyme responsible for activating many cell functions. The new information, reported in Cell, is a crucial step in the potential development of cancer drugs to control unchecked cell growth and metastasis.
Childhood cancer patients, long-term survivors and their families will find hope, help and a place for personal expression in "OUTLOOK: Life Beyond Childhood Cancer," a new Internet site developed by a University of Wisconsin-Madison team led by a 22-year-old leukemia survivor.
The biological clock reminds us to go to sleep every 24 hours, but under certain lighting conditions another internal regulator may be telling us to take a nap. University of Wisconsin Medical School researchers have pinpointed two connected mid-brain structures that control the way light affects rodent sleep activity that's separate from the biological clock.
University of Wisconsin Medical School researchers have solved the puzzle of how lithium can effectively stabilize both the wild euphoria and the crushing melancholy that are the hallmark of bipolar disorder. They found that in mice brains, lithium causes the neurotransmitter glutamate to level off in a stable zone where it can control both extremes.
Obstetricians regularly prescribe bed rest for women with complicated pregnancies, but many appear to be unaware of the harmful side effects of the inactivity, according to a study by UW-Madison School of Nursing researchers. Published in the current Journal of Women's Health, the study also showed that obstetricians vary greatly in the degree of restriction ordered for the same problem, as well as the location of bed rest--hospital or home.
In back-to-back reports in Science and Cell, researchers at the University of Wisconsin Medical School describe important new data on proteins that detect and repair gene damage. The findings provide direct evidence for the cause of a genetic disorder that greatly increases the risk of cancer, as well as broader insights into a fundamental system that can lead to malignancy when it fails to function properly.
With the unlikely but invaluable help of an electron accelerator, University of Wisconsin Medical School molecular biologists have definitively shown for the first time that within the seven-some-feet of the folded chromosome in every cell nucleus, special repair proteins do their work by moving from their home bases to remote gene damage sites. The study is reported in the April 24 Science.
Scientists from around the world will gather at the University of Wisconsin, April 17-18, to discuss their latest findings demonstrating the biological underpinnings of emotion, and the profound effects positive and negative feelings can have on human health. The latest technological advances used to identify brain systems associated with different emotions will also be described.
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