Scientists from the Vienna BioCenter have pushed SARS-CoV-2 detection to a new level. Their approach is as sensitive and robust, yet cheaper, simpler and faster to implement than conventional tests. 'bead-LAMP' and 'HomeDip-LAMP' could be game-changers for population-wide screening, especially in disadvantaged environments, such as developing countries.
Neurobiologists solve long-standing question over how brains orchestrate complex behaviours. The scientists from the lab of Manuel Zimmer showed that such behaviours are controlled by hierarchical neural activity, as they now reported in the journal Neuron.
New insights into the process of DNA-looping change our view of how the genome is organised within cells. The discoveries by IMP-researchers elucidate a fundamental mechanism of life and settle a decade long scientific dispute.
The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity. Scientists from the lab of Meinrad Busslinger now reported in the journal "Nature Immunology" how the protein lkaros orchestrates the fine balance between B cell silencing and activation - and thereby controls autoimmunity.
Emily Bayer of Columbia University, Mohamed El-Brolosy of the Max Planck Institute for Heart and Lung Research, and Justin Silpe of Princeton University: three exceptional young scientists were chosen to be the first laureates of the new International Birnstiel Award for Doctoral Studies in the Molecular Life Sciences.
Using an unbiased labelling technique, mathematical modelling, and single cell profiling to trace the footsteps of stem cells and their daughters, researchers at the University of Cambridge (UK), DGIST (S.Korea), and IMBA (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria) have confirmed that two populations of adult stem cells with distinct roles and characteristics reside in the glands of the stomach.
Researchers at IMBA - Institute for Molecular Biotechnology of the Austrian Academy of Sciences – describe “adaptive radiation” of RNA export proteins. Their findings show how a small RNA pathway utilizes and re-purposes preexisting building blocks in the cell to protect genome integrity.
Changes in blood vessels are the major cause of death and morbidity in diabetes. For the first time, sci-entists managed to grow perfect human blood vessels as organoids in a petri dish. This breakthrough engineering technology dramatically advances research of vascular dysfunction in diseases like diabetes, identifying a key pathway that prevents diabetic vasculopathy, as reported in the current issue of Nature.
Scientists at IMBA - Institute of Molecular Biotechnology at the Austrian Academy of Sciences - together with the Boston Children's Hospital at Harvard, demonstrate a completely new way of combating autoimmune diseases and cancer.
Scientists have long argued over which cells enable salamanders to grow back lost limbs. By tracking lineages and characterising individual cells, researchers could now show that connective tissue cells develop stem-cell-like properties and underlie the regeneration of legs. The findings were published in the journal “Science”.
Fertilisation is a pivotal process underlying all sexual reproduction, yet its molecular mechanisms are poorly understood. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have now identified a protein they called “Bouncer” as a crucial factor for sperm entry into the egg. Remarkably, this protein is sufficient to allow fertilization between different species. The study is published in the current issue of the journal Science.
For the first-time, researchers at IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences – develop organoids, that mimic the onset of brain cancer. This method not only sheds light on the complex biology of human brain tumors but could also pave the way for new medical applications.
Cells acquire distinct fates and functions during development. A study from the IMBA reveals a new mechanism of cell fate specification involving the regulation of cell metabolism.
Scientists from two institutes at the Vienna BioCenter (VBC) have developed a method to identify and characterise microRNAs in individual cells of living animals.
Scientists in Vienna, Dresden and Heidelberg have decoded the entire genetic information of the Mexican salamander axolotl, the largest genome ever to be sequenced. This will be a powerful tool to study the molecular basis of regeneration. The journal NATURE publishes the news today.
CRISPR-UMI, a novel method developed at IMBA, facilitates extremely robust and sensitive screens by tracking single mutants within a population of cells.
Glycosylation is the most abundant protein modification - over half of the proteins in our cells are ‘decorated’ with glycans. These sugar structures alter protein activities in all organisms – from bacteria to human - influencing fundamental processes, like protein folding and transport, cell migration, cell-cell interactions, and immune responses.
Researchers at the Austrian Academy of Sciences’ Institute for Molecular Biotechnology (IMBA) have discovered a means of immunising cells against the biological weapon ricin, as reported in the current issue of Cell Research.
How a protein BAF crosslinks the DNA to allow proper nuclear envelope reformation
Researchers at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - unveil novel mechanism for gene expression.
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