Small Molecule Exploits Achilles’ Heel of AML, Kills Cancer Cells
Cincinnati Children's Hospital Medical CenterBlocking the protein UBE2N with novel small molecule kills AML cells, according to study in Science Translational Medicine.
Blocking the protein UBE2N with novel small molecule kills AML cells, according to study in Science Translational Medicine.
Cincinnati Children’s Hospital Medical Center is celebrating the completion of a new Critical Care Building, a $600 million investment that involved three years of construction on the hospital’s main campus in Avondale.
A study published in the journal Pediatrics shows the combination of two early reading programs had positive effects on preschool students entering kindergarten in Cincinnati Public Schools over a three-year period.
Researchers at Cincinnati Children’s Hospital Medical Center have developed a new framework for different factors influencing how a child’s brain is “wired” to learn to read before kindergarten.
The Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM) is a new system for patients with acute kidney injury or kidney failure requiring dialysis. This ground-breaking technology is intended to provide continuous renal replacement therapy (CRRT) to patients weighing between 5 and 20 pounds.
A study published in the journal Pediatrics expands validation evidence for a new screening tool that directly engages preschool-age children during clinic visits to assess their early literacy skills. The tool, which is the first of its kind, has the potential to identify reading difficulties as early as possible, target interventions and empower families to help their child at home, according to researchers at Cincinnati Children’s Hospital Medical Center.
Cincinnati Children’s Hospital Medical Center and TriHealth are announcing the expansion of the special delivery unit at the Cincinnati Children’s Fetal Care Center.
Cincinnati Children’s Hospital Medical Center today named Visael “Bobby” Rodriguez as its vice president of diversity, inclusion and community relations.
Tina L. Cheng, MD, MPH, will be the new chair of the Department of Pediatrics at the University of Cincinnati College of Medicine, the new chief medical officer at Cincinnati Children’s Hospital Medical Center, and director of the Cincinnati Children’s Research Foundation.
The combination of higher exposure to air pollution and pre-existing health disparities is contributing to higher mortality among minority populations during the COVID-19 pandemic, according to experts at Cincinnati Children's.
A study published online April 20, 2020, in Nature Immunology, led by researchers at Cincinnati Children's reports a possible new approach for treating myelodysplastic syndrome (MDS), which often can lead to leukemia.
New research data in the journal PLoS Pathogens suggests that reactivated HSV in trigeminal nerves of laboratory mice kills off at least a portion of sensory neurons. The findings provide additional evidence that as humans get older, the long-term consequences of HSV infection in the nervous system can accumulate and cause neurological damage.
The continuing epidemic of pre-term birth includes this stark reality: tiny, fragile babies are born with underdeveloped lungs and prone to lifelong respiratory infections and related chronic illnesses. Cincinnati Children’s researchers report in Immunology the discovery of a complex biological process could in the development of cost effective treatments to help babies develop lifelong pulmonary resistance to respiratory infections.
A new study suggests that significant early childhood exposure to traffic-related air pollution (TRAP) is associated with structural changes in the brain at the age of 12. The Cincinnati Children’s Hospital Medical Center study found that children with higher levels of TRAP exposure at birth had reductions at age 12 in gray matter volume and cortical thickness as compared to children with lower levels of exposure.
Report led by experts at Cincinnati Children's, published today in Pediatrics, urges pediatricians to increase support for parents of children with chronic conditions.
Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases. In a study published online Dec. 17, researchers report their data have implications for Multiple Sclerosis, Type 1 diabetes and Inflammatory Bowel Disease. It also will help efforts to find better treatments for autoimmune disease, still an urgent need in medicine.
The Influenza IMPRINT Cohort study will explore the emerging idea that a person’s very first influenza virus exposure impacts the magnitude, durability and breadth of their immune response to all future flu exposures.
Although KJ Upshaw’s official job title at Cincinnati Children’s is floor tech in Environmental Services, he refers to himself simply as the housekeeper. For two little boys in the medical center’s Bone Marrow Transplant unit, KJ is much more. He’s a cherished friend who helped make their lives in the hospital brighter and more fulfilling.
A study in Nature shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.
After decades of little or no progress, biomedical researchers are finally making some headway at detecting and treating sepsis, a deadly medical complication that sends a surge of pathogenic infection through the body and remains a major public health problem. They report data in Science Translational Medicine.