Latest News

• share
• favorite_border

BioMed Valley Discoveries (BVD) announced today they will present four posters at the upcoming American Association for Cancer Research (AACR) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana.

• share
• favorite_border

In this study, the Sánchez Alvarado Lab shows that whole-body regeneration involves transcriptional changes in cells from all three germ layers (muscle, epidermis, and intestine) of the body, and that tissue from areas distant from, as well as nearby to the site of injury, contribute to the process of regeneration.

• share
• favorite_border

Stowers Institute Co-Founder Virginia Stowers, 1930-2021

• share
• favorite_border

The Piotrowski Lab has reported newly identified invasive ionocytes in the sensory organs of larval and adult zebrafish fish that may provide clues to how sensory organs continue to function in changing environments.

• share
• favorite_border

Since the beginning of the pandemic, a loss of smell has emerged as one of the telltale signs of COVID-19.

• share
• favorite_border

Researchers at the Stowers Institute for Medical Research, in collaboration with colleagues at Stanford University and Technical University of Munich have developed advanced explainable artificial intelligence (AI) in a technical tour de force to decipher regulatory instructions encoded in DNA. In a report published online February 18, 2021, in Nature Genetics, the team found that a neural network trained on high-resolution maps of protein-DNA interactions can uncover subtle DNA sequence patterns throughout the genome and provide a deeper understanding of how these sequences are organized to regulate genes.

• share
• favorite_border

What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility.

• share
• favorite_border

In a new study, researchers at the Stowers Institute for Medical Research have identified a handful of variations in an amino acid sequence critical for retaining the ancestral function of a gene over the course of 600 million years of evolution.

• share
• favorite_border

It can be hard to dispute the common adage ‘survival of the fittest’. After all, “most of the genes in the genome are there because they’re doing something good,” says Sarah Zanders, PhD, assistant investigator at the Stowers Institute for Medical Research. But, she says, “others are just there because they’ve figured out a way to be there.”

• share
• favorite_border

Researchers at the Stowers Institute for Medical Research in Kansas City, Missouri, and the Andalusian Center of Developmental Biology at Pablo de Olavide University in Seville, Spain, have harnessed the technology to target gene messages (messenger RNA) involved in early vertebrate development.

• share
• favorite_border

BioMed Valley Discoveries (BVD), a clinical stage biotechnology company, announces the receipt of Fast Track designation from the US Food and Drug Administration (FDA) for investigation of the ERK inhibitor ulixertinib (BVD-523) as a treatment for patients with non-colorectal, solid tumors that harbor BRAF mutations G469A/V, L485W, or L597Q. BVD has launched a Phase II multi-center study of ulixertinib for patients with advanced malignancies harboring these atypical (non-V600) BRAF alterations or a MEK alteration.

• share
• favorite_border

Cavefish may not seem like a big deal. They’re small, they live in tucked away places humans rarely go, and they’re common enough that you can find them on every continent except Antarctica. But researchers from the Stowers Institute for Medical Research see them as a potential way to understand more about the rise in autoimmune diseases in humans.

• share
• favorite_border

Scientists at the Stowers Institute for Medical Research have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models of Cornelia de Lange syndrome. People with this rare genetic disorder often harbor mutations in cohesins, ring-like proteins that help DNA organize and repair itself.

• share
• favorite_border

The Stowers Institute for Medical Research is pleased to announce that Joan Weliky Conaway, PhD, a Stowers Investigator since 2001, has been elected a member of the prestigious National Academy of Sciences (NAS) for her distinguished and continuing achievements in original scientific research. The recognition reflects the exceptional productivity and impact of the research program co-led by Conaway and her lifelong collaborator and husband Ron Conaway, PhD.

• share
• favorite_border

Drug resistance is a major obstacle in cancer treatment—leading to relapse for many patients. In a new study, published online April 20, 2020, in Nature Cell Biology, researchers from the Stowers Institute for Medical Research, Children’s Mercy Kansas City, and The University of Kansas Cancer Center report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.

• share
• favorite_border

Researchers at the Stowers Institute for Medical Research have fine-tuned a method to pinpoint surfaces within large multi-protein complexes that are close to, and likely to be directly interacting with, one another.