Research in C. elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases
Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders.
Our epigenome is a set of chemical switches that turn parts of our genome off and on and are impacted by environmental factors including diet, exercise and stress. Research at the Buck Institute reveals that aging also effects the epigenome in human skeletal muscle. The study provides a method to study sarcopenia, the degenerative loss of muscle mass that begins in middle age.
To tackle the rising prevalence of age-related diseases and the challenges and opportunities presented by a growing elderly population, the USC Davis School of Gerontology and the Buck Institute for Research on Aging today announced a joint Ph.D. program in the Biology of Aging, the first in the nation.
The major genetic risk factor for Alzheimer’s disease, present in about two-thirds of people who develop it, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the unsolved mysteries of AD is how ApoE4 causes this risk. Researchers at the Buck Institute have found a link between ApoE4 and SirT1, an “anti-aging protein” that is targeted by resveratrol, present in red wine.
Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day – compared to adults who experience all sorts of agony following the same junk food binge? Evolution and a gene called Foxo may be to blame.
Research focused on the regulation of the adult stem cells that line the gastrointestinal tract of Drosophila suggests new models for the study of Barrett’s esophagus. Barrett’s esophagus is a condition in which the cells of the lower esophagus transform into stomach-like cells. In most cases this transformation has been thought to occur directly from chronic acid indigestion. A new study suggests a change in stem cell function for this transformation.
Mice suffering from age-related heart disease saw a significant improvement in cardiac function after treatment with the FDA-approved drug rapamycin for just three months. Research at the Buck Institute shows how rapamycin impacts mammalian tissues, providing functional insights and possible benefits for a drug that can extend lifespan in mice as much as 14 percent. Researchers at the Mayo clinic are now recruiting seniors with cardiac artery disease for a clinical trial involving the drug.
Scientists seeking to develop treatments for Huntington’s disease just got a roadmap that could dramatically speed their discovery process. Researchers at the Buck Institute have used RNAi technology to identify hundreds of “druggable” molecular targets linked to the toxicity associated with HD. The gene RRAS, involved in cell motility and neuronal development , was among the diverse range of modifiers identified. RRAS was revealed as a potent modulator of HD toxicity in multiple HD models.
Rapamycin, an FDA-approved immunosuppressant drug under study in aging research labs, improved function and extended survival in mice suffering from a genetic mutation which leads to dilated cardiomyopathy (DCM) and rare muscular dystrophies in humans. There are currently no effective treatment for the diseases, which include Emery-Dreifuss Muscular Dystrophy and Limb-Girdle Muscular Dystrophy.
Dietary restriction alone does not extend lifespan – at least in fruit flies. Flies, which share many genetic similarities with humans, need physical activity in order to live longer on a Spartan diet. If the same axiom holds true in humans, those practicing caloric restriction in hopes of living longer need to make sure they eat enough to avoid fatigue.
Researchers at the Buck Institute for Research on Aging have corrected the genetic mutation responsible for Huntington’s Disease (HD) using a human induced pluripotent stem cell (iPSC) that came from a patient suffering from the incurable, inherited neurodegenerative disorder. Scientists took the diseased iPSCs, made the genetic correction, generated neural stem cells and then transplanted the mutation-free cells into a mouse model of HD where they are generating normal neurons in the area of the brain affected by HD.
New research from the Buck Institute, built on spinal cord injury research, shows that modifying the scar tissue that develops following a stroke is a promising avenue for future treatments. The need for therapeutics for chronic stroke is compelling. There are 750,000 new strokes per year in the U.S., a leading cause of morbidity and mortality.
Alliance for Aging Research and the Buck Institute for Research on Aging urge support for research agenda aimed at extending healthy years of life. Nearly 70 prominent scientists endorse the plan and call for more federal funding.
About 18 million individuals undergo massage therapy annually in the U.S. Despite several reports that long-term massage therapy reduces chronic pain and improves range of motion in clinical trials, the biological effects of massage on skeletal tissue have remained unclear - until now.
The partnership, aimed at drug development, builds on observations that rapamycin extends healthy lifespan in several species.
When researchers at the Buck Institute dialed back activity of a specific mRNA translation factor in adult nematode worms they saw an unexpected genome-wide response that effectively increased activity in specific stress response genes that could help explain why the worms lived 40 percent longer under this condition. The study highlights the importance of mRNA translation in the aging process.
Buck Institute research in mice moves into preclinical stage; Buck working toward human trials.
Buck Institute study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability. Results provide missing piece of DR puzzle.
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