Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

Palikuqi et al. employ imaging of cleared intestinal tissue, transcriptional analyses, and genetic mouse models to investigate the role of lymphatic endothelial cells in the intestinal stem cell niche. The authors demonstrate that lymphatic endothelial cells are an essential source of Rspo3 for proper intestinal recovery after cytotoxic injury.