Credit: ORNL/Jill Hemman
Scientists used neutrons to better understand how an antimicrobial peptide known as aurein 1.2 kills antibiotic resistant bacteria by attacking their membranes. As the peptide concentration increases (yellow), aurein 1.2 induces lipid molecule clusters (white) within the membrane, making it thicker, more rigid, and more susceptible to break down under stress. Their findings could inform new strategies for treating infections where antibiotics have fallen short.