“Polycomb bodies”: Illustration of the results of Glancy, Wang et al. (2023) Molecular Cell. Blue PRC2.1 and PRC2.2 protein complexes target DNA in different ways, through CG-rich sequences or ubiquitin-modified histones, respectively. They catalyze different levels of the red H3K27me3 repressive mark. They recruit different versions of the green PRC1 complexes, characterized by the presence of the CBX2/4 or CBX7 proteins. PRC1 complexes promote contacts between yellow nucleosomes to mediate gene repression. Artwork by Ellen Tuck.