SCHEMATIC DIAGRAM HIGHLIGHTING PROPOSED MECHANISM OF ACTION OF CAR PEPTIDE. SYSTEMICALLY ADMINISTERED CAR PEPTIDE ASSOCIATES WITH THE HSPG SDC4, WHICH IS RESTRICTED TO EPIDERMIS AND BLOOD VESSELS IN MOUSE SKIN WOUNDS. CAR INDUCES SDC4-DEPENDENT ACTIVATION OF THE SMALL GTPASE ARF6, VIA THE GUANINE NUCLEOTIDE EXCHANGE FACTOR CYTH2, TO PROMOTE SDC4-, ARF6- AND CYTH2-MEDIATED KERATINOCYTE MIGRATION AND ENDOGENOUS RE-EPITHELIALISATION AND WOUND REPAIR MECHANISMS.