A fluorescent image of a testicular organoid created from mouse embryos and incubated in a dish for 14 days. The tubular structures formed in the dish are clearly visible. Marked in green are Sertoli cells, which are the cells responsible for the formation of the tubules in the testicle and, indeed, create the tubules in the dish.

Testicular organoids generated from mice pups and incubated in a dish for 21 days. Labelled in red are Sertoli cells, which are the cells responsible for the formation of the tubules in the testicle and, indeed, create the tubules inside the organoid - as in a real testicle.

Testicular organoids generated from mice pups and incubated in a dish for 21 days. Sertoli cells, which are the cells responsible for the formation of the tubules in the testicle, appear in red and germ cells, which will produce the sperm cells, appear in green. Germ cells always stay close proximity to Sertoli cells as they support them during the formation of sperm cells.

Image of real testes of 28-day-old mice. The Sertoli cells, which are the cells responsible for the formation of the tubules in the testicle, are marked in red and the unmarked tubules of the testicle in which the sperm cells are produced are clearly seen.

Dr. Nitzan Gonen in her lab at Bar-Ilan University

Left to right: Dr. Nitzan Gonen, Stav Dahari, Cheli Lev and Aviya Stopel

Plastic plate containing the testis organoids being cultured in an incubator