Credit: Steffen Grosser, Frank Sauer, and Eliane Blauth
Two malignant mixed mullerian tumor explants on collagen network. Both tumor pieces adhered to the collagen network and started pulling on the collagen fibers, which prompted extensive collagen displacements and alignments, alongside cell escape of cells with a dominant stress fiber-based contractility. The sharp and smooth boundary structure of both pieces further indicates a strong tissue surface tension that hinders cell escape for cells with a dominant cortical contractility.