The beneficial characteristics of Nbs for food allergen surveillance. (A) Almost 90% of all serious food allergies are related to proteins (allergens) in nine foods including egg, milk, peanut, and tree nuts. The incidence of food allergen exposure occures during the complete food chain from manufacturing to transportation with unexpected contamination or intentional supplementation; (B) The comprehensive analysis of food allergen in the complete food chain is proposed with Nb-based immunoassay, and certain properties of Nbs potentially benefit food allergen surveillance with Nb-based immunoassays; and (C) The unique characteristics facilitate Nbs as the perfect candidates for research and application in the field of food allergen surveillance.