New Study Defines the Genetic Map of the Jewish Diasporas

Newswise — August 6, 2012 — (Bronx, NY) — A new genetic analysis focusing on Jews from North Africa has provided an overall genetic map of the Jewish Diasporas. The findings support the historical record of Middle Eastern Jews settling in North Africa during Classical Antiquity, proselytizing and marrying local populations, and, in the process, forming distinct populations that stayed largely intact for more than 2,000 years. The study, led by researchers at Albert Einstein College of Medicine of Yeshiva University, was published online today in the Proceedings of the National Academy of Sciences. “Our new findings define North African Jews, complete the overall population structure for the various groups of the Jewish Diaspora, and enhance the case for a biological basis for Jewishness,” said study leader Harry Ostrer, M.D., professor of pathology, of genetics and of pediatrics at Einstein and director of genetic and genomic testing for the division of clinical pathology at Montefiore Medical Center. Dr. Ostrer noted that obtaining a comprehensive genetic fingerprint of various Jewish subpopulations can help reveal genetic links to heart disease, cancer, diabetes and other common diseases.

In a previous genetic analysis, the researchers showed that modern-day Sephardic (Greek and Turkish), Ashkenazi (Eastern European) and Mizrahi (Iranian, Iraqi and Syrian) Jews that originated in Europe and the Middle East are more related to each other than to their contemporary non-Jewish neighbors, with each group forming its own cluster within the larger Jewish population. Further, each group demonstrated Middle-Eastern ancestry and varying degrees of mixing with surrounding populations. Two of the major Jewish populations—Middle Eastern and European Jews—were found to have diverged from each other approximately 2,500 years ago.

The current study extends that analysis to North African Jews—the second largest Jewish Diaspora group. Their relatedness to each other, to other Jewish Diaspora groups, and to their non-Jewish North African neighbors had not been well defined. The study also included members of Jewish communities in Ethiopia, Yemen and Georgia. In all, the researchers analyzed the genetic make-up of 509 Jews from 15 populations along with genetic data on 114 individuals from seven North African non-Jewish populations.

North African Jews exhibited a high degree of endogamy, or marriage within their own religious and cultural group in accordance with custom. Two major subgroups within this overall population were identified: Moroccan/Algerian Jews and Djerban (Tunisian)/Libyan Jews. The two subgroups varied in their degree of European mixture, with Moroccan/Algerian Jews tending to be more related to Europeans—most likely stemming from the expulsion of Sephardic Jews from Spain during the Inquisition, starting in 1492. Ethiopian and Yemenite Jewish populations also formed distinctive genetically linked clusters, as did Georgian Jews .

Dr. Ostrer’s paper is titled, “North African Jewish and non-Jewish populations form distinctive, orthogonal clusters.” Additional Einstein contributors include: Christopher Campbell, Gil Atzmon, Ph.D., Carole Oddoux, Ph.D., Alexander Pearlman, Ph.D., and Edward R. Burns, M.D. Other contributors include: Pier Francesco Palamara and Itsik Pe'er, Ph.D. (Columbia University, New York, NY); Laura Rodríguez-Botigué and David Comas Martínez (Universitat Pompeu Fabra, Barcelona, Spain); Marc Fellous, M.D., Ph.D. (Cochin Institute, Inserm, Paris, France); Li Hao, Ph.D. (University of Medicine and Dentistry of New Jersey, Newark, NJ); Brenna Henn, Ph.D., and Carlos Bustamante (Stanford School of Medicine, Stanford, CA); Maya Dubrovsky and Eitan Friedman, M.D., Ph.D (Tel-Aviv University, Tel Aviv, Israel).

The research was supported by grants from the Lewis and Rachel Rudin Foundation; the Iranian-American Jewish Federation of New York; the U.S.-Israel Binational Science Foundation; National Cancer Institute (CA121852) of the National Institutes of Health; and Ruth and Sidney Lapidus.

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About Albert Einstein College of Medicine of Yeshiva University Albert Einstein College of Medicine of Yeshiva University is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2011-2012 academic year, Einstein is home to 724 M.D. students, 248 Ph.D. students, 117 students in the combined M.D./Ph.D. program, and 368 postdoctoral research fellows. The College of Medicine has 2,522 full time faculty members located on the main campus and at its clinical affiliates. In 2011, Einstein received nearly $170 million in awards from the NIH. This includes the funding of major research centers at Einstein in diabetes, cancer, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Through its extensive affiliation network involving Montefiore, Jacobi Medical Center –Einstein’s founding hospital, and five other hospital systems in the Bronx, Manhattan, Long Island and Brooklyn, Einstein runs one of the largest post-graduate medical training programs in the United States, offering approximately 155 residency programs to more than 2,200 physicians in training. For more information, please visit www.einstein.yu.edu and follow us on Twitter @EinsteinMed.